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GENE：PIK3R3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3R3
FullNmae phosphoinositide-3-kinase regulatory subunit 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8981
EnsembleID ENSG00000117461
Uniprot Q92569

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3R3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3R3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PIK3R3 GO:0001784,GO:0001934,GO:0002042,GO:0005515,GO:0005829,GO:0005942,GO:0005943,GO:0006955,GO:0008286,GO:0010628,GO:0016303,GO:0030183,GO:0030217,GO:0030335,GO:0036092,GO:0043491,GO:0043551,GO:0046854,GO:0046935,GO:2000811

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3R3 hsa:8503 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04210 Apoptosis - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04218 Cellular senescence - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04360 Axon guidance - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04510 Focal adhesion - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04611 Platelet activation - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04929 GnRH secretion - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04931 Insulin resistance - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05020 Prion disease - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05131 Shigellosis - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05135 Yersinia infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05142 Chagas disease - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05146 Amoebiasis - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05160 Hepatitis C - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05161 Hepatitis B - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05162 Measles - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05164 Influenza A - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05210 Colorectal cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05213 Endometrial cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05214 Glioma - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05215 Prostate cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05218 Melanoma - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05224 Breast cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05226 Gastric cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
PIK3R3 hsa:8503 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIK3CD PIK3R3 23180781 9113989 physical association gst pull down InnateDB
AXL PIK3R3 12470648 23180781 physical association two hybrid InnateDB
EGR1 PIK3R3 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CD19 PIK3R3 20005715 interaction type N/A PSP
IRS1 PIK3R3 20005715 21071413 9415396 interaction type N/A PSP,SignaLink
IRS2 PIK3R3 20005715 interaction type N/A PSP
IRS2 PIK3R3 10417350 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PIK3R3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PIK3R3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PIK3R3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PIK3R3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MZF1 PIK3R3 23509792 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E PIK3R3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000134ADC PIK3R3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC PIK3R3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006FDD4 PIK3R3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 PIK3R3 24632606 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS0000367985 PIK3R3 24469061 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000028BB8 PIK3R3 25416803 26252738 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000000C73C PIK3R3 25416803 26820128 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
INSR PIK3R3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIK3R2 PIK3R3 25348397 N/A physical interaction ComPPI
FRS3 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PLEKHF2 PIK3R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CEP19 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PBX4 PIK3R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNNC2 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VCP PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
E2F6 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
RING1 PIK3R3 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AMBP PIK3R3 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CRK PIK3R3 19380743 24234451 25348397 25814554 association,physical association physical interaction,two hybrid array,tandem affinity purification,validated two hybrid ComPPI,IntAct
VBP1 PIK3R3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DDIT4L PIK3R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZMAT1 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ERBB2 PIK3R3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
CBL PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
BTK PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
TEC PIK3R3 14525934 25348397 9178903 N/A two hybrid,two hybrid ComPPI,HPRD
TGFBR2 PIK3R3 25348397 N/A physical interaction ComPPI
KIT PIK3R3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
LYN PIK3R3 25348397 N/A physical interaction ComPPI
PIK3R1 PIK3R3 25348397 N/A physical interaction ComPPI
SRC PIK3R3 22402981 24234451 25348397 25814554 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
NCK1 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
KHDRBS1 PIK3R3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SKAP1 PIK3R3 25348397 N/A physical interaction ComPPI
GRB2 PIK3R3 21706016 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1 PIK3R3 12588990 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AR PIK3R3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MECOM PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
BLK PIK3R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPARA PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PDGFRB PIK3R3 11172806 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
IRS2 PIK3R3 10417350 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIK3CB PIK3R3 22402981 24234451 25348397 25814554 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
IRS4 PIK3R3 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GAB1 PIK3R3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3CA PIK3R3 14525934 22402981 24234451 25348397 25814554 26496610 9415396 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
PIK3R3 AXL 12470648 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIK3R3 DRAP1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PIK3R3 ESR1 14525934 15001646 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3R3 IRS1 10417350 14525934 24234451 25348397 25814554 7542745 9415396 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,HPRD,IntAct
PIK3R3 INSR 14525934 25348397 9524259 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PIK3R3 ABCB6 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 ORM1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 SERF1A 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 GC 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 KARS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 MICAL1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 DSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 QARS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 DARS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 KLC2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 TRMT2A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 PSME1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 CEP126 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 LUC7L2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 FBN3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R3 EGFR 16273093 24234451 24658140 25241761 25348397 physical association protein array,ubiquitin reconstruction,physical interaction,proximity ligation assay ComPPI,IntAct
PIK3R3 ERBB3 16273093 24189400 24234451 25348397 association protein array,physical interaction,tandem affinity purification ComPPI,IntAct
PIK3R3 MBIP 25348397 N/A physical interaction ComPPI
PIK3R3 TRIM54 25348397 N/A physical interaction ComPPI
PIK3R3 L3MBTL3 25348397 N/A physical interaction ComPPI
PIK3R3 FSD2 25348397 N/A physical interaction ComPPI
PIK3R3 EFNB2 25348397 N/A physical interaction ComPPI
PIK3R3 SOCS6 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 BTN2A1 25348397 N/A physical interaction ComPPI
PIK3R3 VSIG4 25348397 N/A physical interaction ComPPI
PIK3R3 RELT 25348397 N/A physical interaction ComPPI
PIK3R3 HEPACAM2 25348397 N/A physical interaction ComPPI
PIK3R3 ABL2 25348397 N/A physical interaction ComPPI
PIK3R3 HCK 25348397 N/A physical interaction ComPPI
PIK3R3 ARL6IP4 25348397 N/A two hybrid,physical interaction ComPPI
PIK3R3 PLEKHS1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,bimolecular fluorescence complementation,validated two hybrid ComPPI,IntAct
PIK3R3 CCDC14 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 IQUB 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 OTUD7B 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 PARD6A 25348397 N/A physical interaction ComPPI
PIK3R3 PCDHB5 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 PELI3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 PLB1 25348397 N/A physical interaction ComPPI
PIK3R3 RBP7 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 SPSB2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 USP2 25348397 N/A physical interaction ComPPI
PIK3R3 METTL27 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 ZNF281 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 STAT3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 CRYBA2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 ANKS1A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 HSH2D 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 CLNK 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PIK3R3 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 FER 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 HROB 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 AUNIP 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 BRK1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 CAMK1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 CCDC33 25348397 N/A physical interaction ComPPI
PIK3R3 CRBN 25348397 N/A physical interaction ComPPI
PIK3R3 KMT2B 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 MTF2 25348397 N/A physical interaction ComPPI
PIK3R3 OLIG1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
PIK3R3 PACRGL 25348397 N/A physical interaction ComPPI
PIK3R3 WDFY3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
PIK3R3 DCAF8 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 WRNIP1 25348397 N/A two hybrid,physical interaction ComPPI
PIK3R3 ZNF451 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 FOXO1 25348397 N/A physical interaction ComPPI
PIK3R3 FYN 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 PPP1R12B 25348397 N/A physical interaction ComPPI
PIK3R3 PTK2 22402981 24234451 25348397 25814554 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
PIK3R3 TERF2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIK3R3 TSPAN2 24234451 25348397 25814554 physical association peptide array,pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PIK3R3 PTP4A3 25348397 N/A physical interaction ComPPI
PIK3R3 PIK3CD 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 EHD2 25348397 N/A physical interaction ComPPI
PIK3R3 HAVCR2 25348397 N/A physical interaction ComPPI
PIK3R3 NISCH 25348397 N/A physical interaction ComPPI
PIK3R3 ALDH3B1 25348397 N/A physical interaction ComPPI
PIK3R3 TMEM52B 25348397 N/A physical interaction ComPPI
PIK3R3 NLGN3 25348397 N/A physical interaction ComPPI
PIK3R3 FLRT1 25348397 N/A physical interaction ComPPI
PIK3R3 HNRNPL 25348397 N/A physical interaction ComPPI
PIK3R3 CD19 24234451 25348397 8647200 physical association coimmunoprecipitation ComPPI,IntAct
PIK3R3 ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
PIK3R3 HTT 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
PIK3R3 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R3 PWP1 24234451 25348397 25814554 physical association two hybrid,two hybrid array ComPPI,IntAct
PIK3R3 RAB11A 24234451 25348397 25814554 N/A peptide array ComPPI,IntAct
PIK3R3 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PIK3R3 ENKD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 TASOR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 SPATA32 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 CCDC89 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 LAP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 NAB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 STAT5B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 BLZF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 NEBL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 C3ORF36 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 SMRP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 ZBTB18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 FNDC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 PRKAR1B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 SERTAD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 KIAA0408 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 PLAAT4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 ANTKMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 SSBP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 RUSC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PIK3R3 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LNX2 PIK3R3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IGF1R PIK3R3 14525934 17360667 24234451 25241761 25348397 9415396 9524259 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
PELO PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
KLF15 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IGF1R PIK3R3 25241761 27898060 9415396 9524259 stimulant N/A OmniPath
PIK3R3 PIK3CA 25814554 26496610 27898060 9415396 stimulant N/A OmniPath
INSR PIK3R3 27898060 7542745 9524259 N/A N/A OmniPath
NEK9 PIK3R3 27898060 7542745 N/A N/A OmniPath
PIK3CD PIK3R3 27898060 9113989 N/A N/A OmniPath
AXL PIK3R3 12470648 27898060 N/A N/A OmniPath
ALK PIK3R3 27322022 27898060 stimulant N/A OmniPath

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