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GENE：PTTG1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTTG1
FullNmae PTTG1 regulator of sister chromatid separation, securin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9690
EnsembleID ENSG00000164611
Uniprot O95997

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTTG1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTTG1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PTTG1 GO:0004869,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006281,GO:0007283,GO:0017124,GO:0045143,GO:0051276,GO:0051301,GO:0140677

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTTG1 hsa:9232 path:hsa04110 Cell cycle - Homo sapiens (human)
PTTG1 hsa:9232 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PTTG1 hsa:9232 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTTG1 CREB1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
LYL1 PTTG1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTTG1 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 PTTG1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 PTTG1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PTTG1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PTTG1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTTG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTTG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTTG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PTTG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF6 PTTG1 20116377 23977008 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PTTG1 14644503 18339849 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PTTG1 14644503 18339849 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTTG1 12355087 15016801 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000BE495 PTTG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PTTG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 PTTG1 23622248 23671127 25416803 mrna cleavage,inhibition clash,miRNA interference luciferase reporter assay TarBase
URS00002075FA PTTG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 PTTG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005E1A16 PTTG1 24314023 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 PTTG1 25416803 27893422 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PTTG1 BTRC 25361965 interaction type N/A PTMCode2
BTRC PTTG1 25361965 interaction type N/A PTMCode2
CDC20 PTTG1 25361965 interaction type N/A PTMCode2
PTTG1 CDC20 25361965 interaction type N/A PTMCode2
PTTG1IP PTTG1 25361965 interaction type N/A PTMCode2
PTTG1 PTTG1IP 25361965 interaction type N/A PTMCode2
NUP98 PTTG1 25361965 interaction type N/A PTMCode2
PTTG1 NUP98 25361965 interaction type N/A PTMCode2
TP53 PTTG1 25361965 interaction type N/A PTMCode2
PTTG1 TP53 25361965 interaction type N/A PTMCode2
CDH1 PTTG1 25361965 interaction type N/A PTMCode2
PTTG1 CDH1 25361965 interaction type N/A PTMCode2
ESPL1 PTTG1 25361965 interaction type N/A PTMCode2
PTTG1 ESPL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRK PTTG1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK1 PTTG1 25348397 N/A physical interaction ComPPI
PIK3R1 PTTG1 25348397 N/A physical interaction ComPPI
PLCG2 PTTG1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
FZR1 PTTG1 25348397 N/A physical interaction ComPPI
PIK3CA PTTG1 25348397 N/A physical interaction ComPPI
BTRC PTTG1 25348397 N/A physical interaction ComPPI
BAG6 PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R5A PTTG1 25348397 N/A physical interaction ComPPI
XRCC6 PTTG1 11238996 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NUP98 PTTG1 25348397 N/A physical interaction ComPPI
XPO1 PTTG1 25348397 N/A physical interaction ComPPI
RAD23A PTTG1 25348397 N/A physical interaction ComPPI
CUL1 PTTG1 20198633 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SYNCRIP PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC20 PTTG1 11553328 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
AURKA PTTG1 25348397 N/A physical interaction ComPPI
PRKN PTTG1 25348397 N/A physical interaction ComPPI
BUB1B PTTG1 25348397 N/A physical interaction ComPPI
HSPG2 PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAE1 PTTG1 25348397 N/A physical interaction ComPPI
YEATS4 PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DNAJA1 PTTG1 14525934 25348397 9915854 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
HNRNPAB PTTG1 25348397 N/A physical interaction ComPPI
ZCCHC17 PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS10 PTTG1 14525934 25348397 9915854 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PTTG1IP PTTG1 10781616 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
ANAPC2 PTTG1 25348397 N/A physical interaction ComPPI
ANAPC11 PTTG1 25348397 N/A physical interaction ComPPI
CDC27 PTTG1 21186364 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PMS1 PTTG1 25348397 N/A physical interaction ComPPI
UBE4A PTTG1 25348397 N/A physical interaction ComPPI
TTLL5 PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2D PTTG1 25348397 N/A physical interaction ComPPI
TP53 PTTG1 12355087 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CAMK2A PTTG1 25348397 N/A physical interaction ComPPI
PTTG1 PTTG2 25348397 N/A physical interaction ComPPI
PTTG1 ESPL1 20360068 24234451 24781523 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PTTG1 DECR1 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
PTTG1 ZC3H3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTTG1 ACTBL2 25348397 N/A physical interaction ComPPI
PTTG1 USP44 25348397 N/A physical interaction ComPPI
MRPL1 PTTG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK1 PTTG1 10656688 14525934 N/A experimental interaction detection HPRD
PTTG1 PTTG1 20360068 24234451 physical association tandem affinity purification IntAct
CHEK1 PTTG1 16647857 27898060 stimulant N/A OmniPath
CHEK2 PTTG1 16647857 27898060 stimulant N/A OmniPath
PTTG1 ESPL1 15678131 15880121 19117984 20360068 24781523 25750436 26186194 26496610 27898060 inhibition N/A OmniPath
MAPK3 PTTG1 10906323 27898060 stimulant N/A OmniPath
E2F1 PTTG1 19837943 27898060 stimulant N/A OmniPath
KLF6 PTTG1 20116377 27898060 inhibition N/A OmniPath
CDK1 PTTG1 10656688 15302935 16964243 18669648 18767875 19651622 19664995 20058876 20068230 20068231 27898060 stimulant N/A OmniPath
MAPK1 PTTG1 10906323 27898060 stimulant N/A OmniPath
ANAPC1 PTTG1 11179223 27898060 inhibition,stimulant N/A OmniPath

Visualization










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