GENE：DKK1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DKK1 |
| FullNmae | dickkopf WNT signaling pathway inhibitor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2891 |
| EnsembleID | ENSG00000107984 |
| Uniprot | O94907 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DKK1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DKK1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DKK1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DKK1 | GO:0000122,GO:0000122,GO:0000902,GO:0001706,GO:0001707,GO:0001942,GO:0002090,GO:0003170,GO:0003197,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005886,GO:0007611,GO:0008083,GO:0010628,GO:0010628,GO:0010977,GO:0030178,GO:0030279,GO:0030326,GO:0030514,GO:0030900,GO:0031901,GO:0032091,GO:0032526,GO:0033137,GO:0039706,GO:0039706,GO:0039706,GO:0042662,GO:0042663,GO:0043066,GO:0043507,GO:0043523,GO:0043523,GO:0045813,GO:0048019,GO:0048019,GO:0050750,GO:0051966,GO:0060070,GO:0060173,GO:0060325,GO:0061743,GO:0090082,GO:0090090,GO:0090090,GO:0090090,GO:0090090,GO:0090090,GO:0090244,GO:0098883,GO:1901296,GO:1902949,GO:1904338,GO:1904723,GO:1904723,GO:1904723,GO:1904958,GO:1905607,GO:2000096,GO:2000726 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DKK1 | hsa:22943 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| DKK1 | hsa:22943 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| DKK1 | hsa:22943 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTNNB1 | DKK1 | 17344318 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| DKK1 | DKK1 | 11357136 11448771 12050670 19874086 22298955 26467481 | interaction type,bind,down-regulates | N/A | Signor |
| DKK1 | LRP6 | 11357136 11448771 18988627 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| DKK1 | KREMEN2 | 12050670 23331499 | stimulation | N/A | SignaLink |
| DKK1 | KREMEN1 | 12050670 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DKK1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | DKK1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | DKK1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTNNB1 | DKK1 | 15592430 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DKK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ASCL1 | DKK1 | 19744316 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA6 | DKK1 | 21811562 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MSC | DKK1 | 19148141 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MSX1 | DKK1 | 22455953 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | DKK1 | 17964517 20697356 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NANOG | DKK1 | 19148141 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU5F1 | DKK1 | 17068183 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SOX2 | DKK1 | 22015605 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | DKK1 | 15229249 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TWIST1 | DKK1 | 18453541 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TWIST2 | DKK1 | 18453541 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000076995 | DKK1 | 20551325 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000001EB3 | DKK1 | 21048943 | rna interference,inhibition | array technology,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000076995 | DKK1 | 20551325 25416803 25846459 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000001EB3 | DKK1 | 21048943 25416803 | mrna cleavage,inhibition | array technology,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000508C13 | DKK1 | 22020335 25416803 28337453 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000077AED | DKK1 | 25416803 26799283 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00000EEE35 | DKK1 | 25416803 27846906 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | DKK1 | 25416803 26986081 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| URS000000C73C | DKK1 | 25416803 26400224 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000031E12 | DKK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00003677B2 | DKK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | DKK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CORO1A | DKK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KRTAP10-1 | DKK1 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| DKK1 | SMAD9 | 15231748 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| DKK1 | LRP5 | 11516963 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| DKK1 | LRP6 | 11357136 11448771 14525934 21944579 21984209 24234451 25348397 | physical association | dynamic light scattering,experimental interaction detection,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vivo,amplified luminescent proximity homogeneous assay,bio-layer interferometry | ComPPI,HPRD,IntAct |
| DKK1 | KREMEN1 | 12050670 14525934 17804805 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| DKK1 | MDFI | 14525934 16189514 19060904 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| DKK1 | DPP4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| DKK1 | POTEI | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | PSMD13 | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | RBM45 | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | PSMD6 | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | TK2 | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | FBLN1 | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | AMZ2 | 25348397 | N/A | physical interaction | ComPPI |
| DKK1 | CTNNB1 | 24234451 25241761 25348397 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| DKK1 | LRP5 | 11448771 11516963 15035989 26186194 27898060 | inhibition | N/A | OmniPath |
| DKK1 | LRP6 | 11357136 1144877 11448771 11516963 15035989 16126904 18505367 21944579 21984209 26186194 27898060 | inhibition,stimulant | N/A | OmniPath |
| TP53 | DKK1 | 18431400 27898060 | stimulant | N/A | OmniPath |
| DKK1 | KREMEN2 | 12050670 27898060 | stimulant | N/A | OmniPath |
| DKK1 | KREMEN1 | 12050670 27898060 | stimulant | N/A | OmniPath |