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GENE：HBEGF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HBEGF
FullNmae heparin binding EGF like growth factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3059
EnsembleID ENSG00000113070
Uniprot Q99075

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HBEGF pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HBEGF immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HBEGF autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HBEGF GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005615,GO:0005886,GO:0005886,GO:0007165,GO:0007173,GO:0007173,GO:0007173,GO:0007517,GO:0008016,GO:0008083,GO:0008083,GO:0008201,GO:0008201,GO:0008284,GO:0009986,GO:0009986,GO:0030297,GO:0030307,GO:0030335,GO:0030666,GO:0030669,GO:0035313,GO:0038134,GO:0038135,GO:0048018,GO:0048661,GO:0050731,GO:0051545,GO:0051549,GO:0051897,GO:0060326,GO:0090303

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HBEGF hsa:1839 path:hsa01522 Endocrine resistance - Homo sapiens (human)
HBEGF hsa:1839 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
HBEGF hsa:1839 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
HBEGF hsa:1839 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
HBEGF hsa:1839 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
HBEGF hsa:1839 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
HBEGF hsa:1839 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
HBEGF hsa:1839 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
HBEGF hsa:1839 path:hsa05219 Bladder cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADAM9 HBEGF 26192618 interaction type N/A ACSN
HBEGF EGFR 10209155 19631971 20430953 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
HBEGF VDR 23180781 24185200 physical association anti tag coimmunoprecipitation InnateDB
HBEGF ERBB4 10209155 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR HBEGF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HBEGF 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HBEGF 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HBEGF 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR HBEGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
MYOD1 HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
RELA HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
SNAI1 HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
SP1 HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
SP3 HBEGF 22641673 trascriptional regulation,stimulation inferred by curator TFlink
WT1 HBEGF 17430890 22641673 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 HBEGF N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 HBEGF 21853268 22310291 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000028BB8 HBEGF 17612493 21853268 22310291 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 HBEGF 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 HBEGF 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 HBEGF 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00003003B4 HBEGF 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 HBEGF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 HBEGF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 HBEGF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C HBEGF 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 HBEGF 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 HBEGF 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F HBEGF 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 HBEGF 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HBEGF EGFR 25361965 interaction type N/A PTMCode2
EGFR HBEGF 25361965 interaction type N/A PTMCode2
HBEGF ERBB4 25361965 interaction type N/A PTMCode2
ERBB4 HBEGF 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
S100A4 HBEGF 19740107 24234451 25348397 N/A far western blotting ComPPI,IntAct
CD44 HBEGF 14525934 25348397 7532176 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CD82 HBEGF 10749879 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MMP7 HBEGF 11825873 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ERBB4 HBEGF 14525934 25348397 9135143 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CD9 HBEGF 11735113 11846885 14525934 1939101 25348397 27898060 8194524 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
BAG1 HBEGF 11340068 25348397 27898060 N/A two hybrid,physical interaction,in vitro ComPPI,OmniPath
ZBTB16 HBEGF 14525934 14597771 15219838 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
EGFR HBEGF 12725245 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FBLN1 HBEGF 11846885 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NRDC HBEGF 11432822 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
HBEGF BCL6 17392284 19337254 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HBEGF HBEGF 11846885 14525934 N/A two hybrid HPRD
LTBP3 HBEGF 11846885 14525934 N/A two hybrid HPRD
HBEGF EGFR 10209155 12725245 14967450 27898060 stimulant N/A OmniPath
HBEGF ERBB2 12958167 27898060 N/A N/A OmniPath
HBEGF ERBB4 10209155 27898060 9135143 stimulant N/A OmniPath
MMP3 HBEGF 11043579 27898060 stimulant N/A OmniPath

Visualization










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