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GENE：HES1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HES1
FullNmae hes family bHLH transcription factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5192
EnsembleID ENSG00000114315
Uniprot Q14469

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HES1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HES1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HES1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HES1 GO:0000122,GO:0000785,GO:0000981,GO:0001222,GO:0001227,GO:0001709,GO:0001889,GO:0003143,GO:0003151,GO:0003266,GO:0003281,GO:0003310,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006357,GO:0007155,GO:0007219,GO:0007219,GO:0007219,GO:0007224,GO:0007399,GO:0008284,GO:0008432,GO:0009952,GO:0010628,GO:0010629,GO:0010977,GO:0014070,GO:0016363,GO:0016477,GO:0021537,GO:0021555,GO:0021557,GO:0021558,GO:0021575,GO:0021861,GO:0021870,GO:0021984,GO:0030324,GO:0030509,GO:0030513,GO:0030901,GO:0035019,GO:0035881,GO:0035910,GO:0042098,GO:0042102,GO:0042491,GO:0042531,GO:0042803,GO:0042826,GO:0043254,GO:0043279,GO:0043388,GO:0043398,GO:0043433,GO:0043565,GO:0045598,GO:0045608,GO:0045665,GO:0045747,GO:0045892,GO:0045944,GO:0045977,GO:0046331,GO:0046425,GO:0046427,GO:0048469,GO:0048538,GO:0048667,GO:0048711,GO:0048715,GO:0048844,GO:0050678,GO:0050767,GO:0051087,GO:0060122,GO:0060164,GO:0060253,GO:0060412,GO:0060675,GO:0060716,GO:0061009,GO:0061102,GO:0061106,GO:0061309,GO:0061626,GO:0061629,GO:0065003,GO:0070888,GO:0070888,GO:0071347,GO:0071356,GO:0071398,GO:0071820,GO:0071820,GO:0072012,GO:0072049,GO:0072050,GO:0072141,GO:0072282,GO:0090102,GO:0090162,GO:0090281,GO:0097066,GO:0097084,GO:0097150,GO:1902870,GO:1905934,GO:1990090,GO:1990837,GO:2000227,GO:2000737,GO:2000974,GO:2000978

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HES1 hsa:3280 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)
HES1 hsa:3280 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
HES1 hsa:3280 path:hsa04950 Maturity onset diabetes of the young - Homo sapiens (human)
HES1 hsa:3280 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
HES1 hsa:3280 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
HES1 hsa:3280 path:hsa05200 Pathways in cancer - Homo sapiens (human)
HES1 hsa:3280 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BLM HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FAAP24 HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCA HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCC HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCE HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCG HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCM HES1 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FAAP100 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FAAP20 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCB 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCF 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 TOP3A 12535671 12972610 16697054 18550849 18931676 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCD2 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
RPA1 HES1 26192618 association N/A ACSN
RPA2 HES1 26192618 association N/A ACSN
RPA3 HES1 26192618 association N/A ACSN
HES1 MRE11 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 RAD50 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 ATR 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 CEBPB 19487031 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBPJ HES1 19487031 23180781 physical association anti tag coimmunoprecipitation InnateDB
HES1 SIRT1 12535671 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
CDKN1C HES1 22705236 23180781 physical association anti tag coimmunoprecipitation InnateDB
HES1 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB
HES1 HES1 20208568 26467481 down-regulates quantity by repression,transcriptional regulation N/A Signor

Source Target Pmid Interactiontype Methods Database
ESR1 HES1 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 HES1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HES1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HES1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 HES1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 HES1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 HES1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 HES1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
LMO3 HES1 21573214 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 HES1 17876798 trascriptional regulation,stimulation inferred by curator TFlink
NHLH2 HES1 21573214 trascriptional regulation,stimulation inferred by curator TFlink
NOTCH3 HES1 22117196 trascriptional regulation,stimulation inferred by curator TFlink
PITX1 HES1 21425961 trascriptional regulation,stimulation inferred by curator TFlink
RELA HES1 17876798 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 HES1 19800882 trascriptional regulation,stimulation inferred by curator TFlink
SNW1 HES1 15546612 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 HES1 19322650 trascriptional regulation,stimulation inferred by curator TFlink
AR HES1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC HES1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG HES1 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA HES1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HES1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000029EBD HES1 19308264 23354452 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00001CC864 HES1 12808467 15066185 rna interference,inhibition experimental interaction detection,western blot,northern blot,miRNA interference luciferase reporter assay miRSponge
URS00003BD367 HES1 22871495 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000029EBD HES1 19308264 23354452 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001CC864 HES1 12808467 15066185 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,miRNA interference luciferase reporter assay TarBase
URS00003BD367 HES1 22871495 25172935 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C3AC1 HES1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 HES1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 HES1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002233F4 HES1 25416803 25998143 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00001FFA8C HES1 25416803 26431046 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000235862 HES1 25416803 27508032 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HES1 ID2 25361965 interaction type N/A PTMCode2
ID2 HES1 25361965 interaction type N/A PTMCode2
HES1 TLE2 25361965 interaction type N/A PTMCode2
TLE2 HES1 25361965 interaction type N/A PTMCode2
HES1 STAT3 25361965 interaction type N/A PTMCode2
STAT3 HES1 25361965 interaction type N/A PTMCode2
HES1 HES6 25361965 interaction type N/A PTMCode2
HES6 HES1 25361965 interaction type N/A PTMCode2
HES1 ID3 25361965 interaction type N/A PTMCode2
ID3 HES1 25361965 interaction type N/A PTMCode2
HES1 ID1 25361965 interaction type N/A PTMCode2
ID1 HES1 25361965 interaction type N/A PTMCode2
HES1 TLE1 25361965 interaction type N/A PTMCode2
TLE1 HES1 25361965 interaction type N/A PTMCode2
HES1 FANCG 25361965 interaction type N/A PTMCode2
FANCG HES1 25361965 interaction type N/A PTMCode2
SIRT1 HES1 25361965 interaction type N/A PTMCode2
HES1 SIRT1 25361965 interaction type N/A PTMCode2
HES1 HES1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HEY2 HES1 11486045 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TLE1 HES1 14525934 25348397 8687460 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
FOXG1 HES1 11238932 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCA HES1 14525934 25348397 9389649 N/A experimental interaction detection,in vitro ComPPI,HPRD
RUNX2 HES1 25348397 N/A physical interaction ComPPI
YWHAB HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GAPDH HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AA1 HES1 25348397 N/A physical interaction ComPPI
PARP1 HES1 25348397 N/A physical interaction ComPPI
CSNK1E HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HEY1 HES1 25348397 N/A physical interaction ComPPI
HMGB1 HES1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SPTAN1 HES1 25348397 N/A physical interaction ComPPI
FANCC HES1 25348397 N/A physical interaction ComPPI
ID3 HES1 11756408 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NR4A1 HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JAK2 HES1 14525934 15156153 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HSPA4 HES1 25348397 N/A physical interaction ComPPI
HDAC6 HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIRT1 HES1 12535671 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
ASGR2 HES1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FANCE HES1 14525934 18550849 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FANCF HES1 14525934 18550849 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FHL1 HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ID1 HES1 11756408 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TLE2 HES1 25348397 N/A physical interaction ComPPI
HES6 HES1 10851137 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ID4 HES1 11756408 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ID2 HES1 11756408 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ELAVL1 HES1 25348397 N/A physical interaction ComPPI
UBQLN1 HES1 14525934 15492808 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
APH1A HES1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LTBR HES1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STAT3 HES1 14525934 15156153 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FANCL HES1 14525934 18550849 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
HES1 HDAC1 25348397 N/A physical interaction ComPPI
HES1 FANCG 14525934 18550849 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
HES1 FANCA 14525934 18550849 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
HES1 HSP90AA2P 25348397 N/A physical interaction ComPPI
HES1 NUDT3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HES1 PTK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HES1 HMGCL 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HES1 NHLH2 25348397 N/A physical interaction ComPPI
HES1 LMO3 25348397 N/A physical interaction ComPPI
APCS HES1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FGFR1 HES1 27898060 9389649 N/A N/A OmniPath
WNT1 HES1 18495817 27898060 stimulant N/A OmniPath
RBPJ HES1 10520600 16682003 27898060 stimulant N/A OmniPath
HES1 RBPJ 10520600 16682003 27898060 inhibition N/A OmniPath
NOTCH1 HES1 18495817 19165418 27898060 stimulant N/A OmniPath
HES1 NR3C1 24300895 27898060 inhibition N/A OmniPath
HES1 DTX1 20208568 27898060 inhibition N/A OmniPath

Visualization










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