GENE：HYAL2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HYAL2 |
| FullNmae | hyaluronidase 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5321 |
| EnsembleID | ENSG00000068001 |
| Uniprot | Q12891 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HYAL2 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HYAL2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HYAL2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HYAL2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HYAL2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HYAL2 | GO:0000139,GO:0000302,GO:0001618,GO:0001822,GO:0002244,GO:0003713,GO:0004415,GO:0004415,GO:0005515,GO:0005540,GO:0005737,GO:0005764,GO:0005783,GO:0005829,GO:0005886,GO:0005886,GO:0005902,GO:0005975,GO:0006027,GO:0009615,GO:0009897,GO:0009986,GO:0009986,GO:0010764,GO:0016324,GO:0019064,GO:0019899,GO:0030139,GO:0030214,GO:0030214,GO:0030214,GO:0030294,GO:0030308,GO:0030971,GO:0031410,GO:0031410,GO:0032755,GO:0032757,GO:0033906,GO:0033906,GO:0035810,GO:0042117,GO:0042307,GO:0043407,GO:0044344,GO:0045121,GO:0045944,GO:0046677,GO:0046718,GO:0048471,GO:0048705,GO:0050431,GO:0050729,GO:0051216,GO:0051607,GO:0051898,GO:0060586,GO:0061099,GO:0070295,GO:0071347,GO:0071356,GO:0071493,GO:0071560,GO:0090575,GO:2001238 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| HYAL2 | hsa:8692 | path:hsa00531 | Glycosaminoglycan degradation - Homo sapiens (human) |
| HYAL2 | hsa:8692 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| HYAL2 | hsa:8692 | path:hsa04142 | Lysosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | HYAL2 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | HYAL2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | HYAL2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FHL3 | HYAL2 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| KRTAP3-2 | HYAL2 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| HYAL2 | MST1R | 12676986 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| HYAL2 | CD44 | 15090545 24234451 25348397 25864644 27898060 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| HYAL2 | KRTAP10-3 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | TAZ | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | PTPRK | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | DPEP2 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | PON2 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | DPEP1 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | SLC39A5 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | FUT3 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | MPPE1 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | TCTN2 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | ST8SIA4 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | NCEH1 | 25348397 | N/A | physical interaction | ComPPI |
| HYAL2 | KRT34 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HYAL2 | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HYAL2 | KRT31 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HYAL2 | KRTAP1-1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HYAL2 | KRTAP6-2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HYAL2 | PELI2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HYAL2 | SMAD4 | 20542955 27898060 | stimulant | N/A | OmniPath |