Gene Information gene info

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GENE：ITGB4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGB4
FullNmae integrin subunit beta 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6158
EnsembleID ENSG00000132470
Uniprot P16144

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGB4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGB4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITGB4 GO:0001664,GO:0005178,GO:0005515,GO:0005604,GO:0005730,GO:0005886,GO:0005886,GO:0005925,GO:0006914,GO:0007155,GO:0007160,GO:0007160,GO:0007229,GO:0008305,GO:0009611,GO:0009925,GO:0009986,GO:0009986,GO:0016477,GO:0030054,GO:0030056,GO:0031252,GO:0031581,GO:0031581,GO:0031965,GO:0031994,GO:0032290,GO:0033627,GO:0035878,GO:0038132,GO:0043235,GO:0043589,GO:0046847,GO:0046872,GO:0048333,GO:0048870,GO:0061450,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGB4 hsa:3691 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGB4 hsa:3691 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGB4 LGALS3 19940114 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGB4 EGFR 19940114 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGFR ITGB4 19940114 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD2 ITGB4 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 ITGB4 18729074 23180781 physical association tandem affinity purification InnateDB

Source Target Pmid Interactiontype Methods Database
GRB2 ITGB4 20005715 interaction type N/A PSP
SHC1 ITGB4 20005715 interaction type N/A PSP
YWHAB ITGB4 20005715 interaction type N/A PSP
YWHAQ ITGB4 20005715 interaction type N/A PSP
YWHAB ITGB4 20005715 20005715 N/A N/A SignaLink
YWHAQ ITGB4 12919677 18988627 20005715 20005715 N/A N/A SignaLink
SHC1 ITGB4 11044453 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 ITGB4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ITGB4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ZEB1 ITGB4 20729552 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C ITGB4 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ITGB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ITGB4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 ITGB4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 ITGB4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000008A99 ITGB4 25416803 26722463 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA ITGB4 22135298 phosphorylation N/A PhosphoSite
MAPK3 ITGB4 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 ITGB4 22135298 phosphorylation N/A PhosphoSite
FGFR1 ITGB4 22135298 phosphorylation N/A PhosphoSite
PRKCA ITGB4 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ITGA3 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 ITGA3 25361965 interaction type N/A PTMCode2
ITGB4 VIM 25361965 interaction type N/A PTMCode2
VIM ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 YWHAQ 25361965 interaction type N/A PTMCode2
YWHAQ ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 ARRDC3 25361965 interaction type N/A PTMCode2
ARRDC3 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 ERBB2 25361965 interaction type N/A PTMCode2
ERBB2 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 PRKCA 25361965 interaction type N/A PTMCode2
ITGB4 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 MET 25361965 interaction type N/A PTMCode2
MET ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 MACF1 25361965 interaction type N/A PTMCode2
MACF1 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 GRB2 25361965 interaction type N/A PTMCode2
GRB2 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 COL17A1 25361965 interaction type N/A PTMCode2
COL17A1 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 EIF6 25361965 interaction type N/A PTMCode2
EIF6 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 ITGA6 25361965 interaction type N/A PTMCode2
ITGA6 ITGB4 25361965 interaction type N/A PTMCode2
ITGB4 SHC1 25361965 interaction type N/A PTMCode2
SHC1 ITGB4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YES1 ITGB4 11684709 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SGTB ITGB4 25348397 N/A physical interaction ComPPI
VIM ITGB4 12441134 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARRDC3 ITGB4 20603614 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
FABP3 ITGB4 20802519 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
VCP ITGB4 25348397 N/A physical interaction ComPPI
ATXN1 ITGB4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GEMIN7 ITGB4 25348397 N/A physical interaction ComPPI
ERBB2 ITGB4 11375975 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ERBIN ITGB4 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
PRKCA ITGB4 10477766 12919677 14525934 15121854 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SHC1 ITGB4 11044453 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKCD ITGB4 11389095 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRB2 ITGB4 14525934 25348397 9171350 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD2 ITGB4 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 ITGB4 25348397 N/A physical interaction,tandem affinity purification ComPPI
CD151 ITGB4 10811835 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
ITGA3 ITGB4 25348397 N/A physical interaction ComPPI
FLNA ITGB4 15225631 24234451 25348397 physical association pull down ComPPI,IntAct
JUP ITGB4 25348397 N/A physical interaction ComPPI
YWHAB ITGB4 12919677 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
BAG6 ITGB4 25348397 N/A physical interaction ComPPI
ILK ITGB4 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU ITGB4 25348397 N/A physical interaction ComPPI
PLEC ITGB4 11328943 14525934 14668477 19242489 24234451 25348397 N/A two hybrid,experimental interaction detection,fluorescence technology,x-ray crystallography,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
SREBF2 ITGB4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CFTR ITGB4 25348397 N/A physical interaction ComPPI
EIF6 ITGB4 14525934 25348397 9374518 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
YWHAQ ITGB4 12919677 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
MET ITGB4 11733063 14525934 14602071 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EGFR ITGB4 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ITGA6 ITGB4 14525934 21880726 24234451 25348397 2649503 9660880 colocalization,physical association cross-linking study,experimental interaction detection,in vivo,confocal microscopy ComPPI,HPRD,IntAct
ITGB4 COL17A1 14525934 14668477 25348397 9660880 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ITGB4 FYN 11684709 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB4 CLCA1 12110680 14512419 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB4 CLCA2 12110680 14512419 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB4 ALOX12 10727209 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ITGB4 DST 10637308 14525934 14668477 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ITGB4 ENPP2 25348397 N/A physical interaction ComPPI
ITGB4 LPAR1 25348397 N/A physical interaction ComPPI
ITGB4 SEL1L 25348397 N/A physical interaction ComPPI
ITGB4 HNRNPD 25348397 N/A physical interaction ComPPI
ITGB4 MYH13 25348397 N/A physical interaction ComPPI
ITGB4 TNRC6A 25348397 N/A physical interaction ComPPI
ITGB4 MYO19 25348397 N/A physical interaction ComPPI
ITGB4 KLC3 25348397 N/A physical interaction ComPPI
ITGB4 PPP2R3C 25348397 N/A physical interaction ComPPI
ITGB4 SKI 25348397 N/A physical interaction ComPPI
ITGB4 MUC5AC 25348397 N/A physical interaction ComPPI
ITGB4 CADM1 21880726 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
ITGB4 TFAP2C 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
ITGB4 S1PR2 24234451 24851274 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ITGB4 S1PR3 24234451 24851274 25348397 physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
ITGB4 PTK2 24234451 25348397 27178753 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
ITGB4 CX3CL1 24234451 24789099 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
ATF2 ITGB4 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB4 PRKDC 24234451 26175416 association chromatin immunoprecipitation assay IntAct
PRKACA ITGB4 17615294 27898060 inhibition,stimulant N/A OmniPath
PRKCA ITGB4 10477766 11438664 12919677 15121854 17615294 19005215 20870721 27898060 inhibition,stimulant N/A OmniPath
PRKD1 ITGB4 22357621 26580203 27898060 stimulant N/A OmniPath
FYN ITGB4 11684709 27898060 N/A N/A OmniPath
ITGB4 EGFR 19940114 27898060 N/A N/A OmniPath
FGFR1 ITGB4 11438664 23677256 27898060 N/A N/A OmniPath
PRKCD ITGB4 11389095 12919677 27898060 stimulant N/A OmniPath
CASP7 ITGB4 17178732 27898060 inhibition,stimulant N/A OmniPath
CASP3 ITGB4 17178732 27898060 inhibition,stimulant N/A OmniPath
ITGB4 PIK3CA 11733063 12867433 27898060 7721947 8143784 9428518 stimulant N/A OmniPath
MET ITGB4 11733063 14602071 27898060 N/A N/A OmniPath
ITGB4 PIK3CD 27898060 9428518 stimulant N/A OmniPath
ITGB4 PIK3CB 11733063 12867433 27898060 7721947 8143784 9428518 stimulant N/A OmniPath
LAMB1 ITGB4 10842354 27898060 stimulant N/A OmniPath
ITGB4 PIK3CG 11733063 12867433 27898060 7721947 8143784 9428518 stimulant N/A OmniPath
ITGA6 ITGB4 10842354 11438664 12867433 21880726 2649503 27898060 9660880 N/A N/A OmniPath
LAMA1 ITGB4 10842354 27898060 N/A N/A OmniPath
DUSP18 ITGB4 10842354 27898060 stimulant N/A OmniPath
MMP7 ITGB4 27898060 9344615 stimulant N/A OmniPath

Visualization










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