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GENE：JAG2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol JAG2
FullNmae jagged canonical Notch ligand 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6189
EnsembleID ENSG00000184916
Uniprot Q9Y219

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
JAG2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
JAG2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
JAG2 GO:0001501,GO:0001701,GO:0003016,GO:0005112,GO:0005112,GO:0005509,GO:0005515,GO:0005886,GO:0005886,GO:0007219,GO:0007283,GO:0008083,GO:0009912,GO:0016331,GO:0030154,GO:0030155,GO:0030217,GO:0042127,GO:0042475,GO:0042492,GO:0045061,GO:0045747,GO:1990134

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
JAG2 hsa:3714 path:hsa01522 Endocrine resistance - Homo sapiens (human)
JAG2 hsa:3714 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
JAG2 hsa:3714 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
JAG2 hsa:3714 path:hsa05200 Pathways in cancer - Homo sapiens (human)
JAG2 hsa:3714 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JAG2 NOTCH2 10958687 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
JAG2 NOTCH3 10958687 11006133 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
JAG2 NOTCH1 10958687 11006133 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
MIB2 JAG2 15920166 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
JAG2 NOTCH1 20005715 interaction type N/A PSP
JAG2 NOTCH2 20005715 interaction type N/A PSP
JAG2 NOTCH3 20005715 interaction type N/A PSP
JAG2 NOTCH1 20005715 N/A N/A SignaLink
JAG2 NOTCH2 20005715 N/A N/A SignaLink
JAG2 NOTCH3 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 JAG2 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 JAG2 16980608 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF JAG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 JAG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 JAG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A JAG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF JAG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 JAG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 JAG2 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 JAG2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 JAG2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE JAG2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000031BC7D JAG2 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS0000077AED JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000157F5 JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002EF20A JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 JAG2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 JAG2 25416803 25998143 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
JAG2 DLL1 25361965 interaction type N/A PTMCode2
DLL1 JAG2 25361965 interaction type N/A PTMCode2
NOTCH1 JAG2 25361965 interaction type N/A PTMCode2
JAG2 NOTCH1 25361965 interaction type N/A PTMCode2
NOTCH3 JAG2 25361965 interaction type N/A PTMCode2
JAG2 NOTCH3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VASN JAG2 25348397 N/A physical interaction ComPPI
NOTCH1 JAG2 11006133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HNRNPL JAG2 25348397 N/A physical interaction ComPPI
GFI1B JAG2 14525934 16713569 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
CACNA1A JAG2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JAG2 NOTCH2 10958687 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
JAG2 NOTCH3 11006133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JAG2 MIB2 25348397 N/A physical interaction ComPPI
JAG2 ATXN7 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JAG2 ATN1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
JAG2 PLPPR1 25348397 N/A physical interaction ComPPI
JAG2 ATP1B4 25348397 N/A physical interaction ComPPI
JAG2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
JAG2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
JAG2 TMEM30B 25348397 N/A physical interaction ComPPI
JAG2 TCTN2 25348397 N/A physical interaction ComPPI
JAG2 STS 25348397 N/A physical interaction ComPPI
JAG2 ADAM32 25348397 N/A physical interaction ComPPI
JAG2 UST 25348397 N/A physical interaction ComPPI
JAG2 TRIM25 25348397 N/A physical interaction ComPPI
DLL1 JAG2 16141228 27898060 N/A N/A OmniPath
MYC JAG2 20133585 27898060 stimulant N/A OmniPath
NOTCH1 JAG2 11006133 15358736 27898060 inhibition N/A OmniPath
JAG2 NOTCH1 11006133 27898060 9315665 inhibition,stimulant N/A OmniPath
JAG2 JAG1 27898060 9315665 stimulant N/A OmniPath
PSEN1 JAG2 12551931 27898060 N/A N/A OmniPath
JAG2 NOTCH2 10958687 27898060 inhibition,stimulant N/A OmniPath
NCSTN JAG2 12551931 27898060 N/A N/A OmniPath
JAG2 NOTCH3 10958687 1100613 11006133 27898060 inhibition,stimulant N/A OmniPath
PSENEN JAG2 12551931 27898060 N/A N/A OmniPath
PSEN2 JAG2 12551931 27898060 N/A N/A OmniPath
APH1A JAG2 12551931 27898060 N/A N/A OmniPath
MIB2 JAG2 15920166 27898060 stimulant N/A OmniPath
APH1B JAG2 12551931 27898060 N/A N/A OmniPath

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