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GENE：MAP2K1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP2K1
FullNmae mitogen-activated protein kinase kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6840
EnsembleID ENSG00000169032
Uniprot Q02750

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP2K1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K1 cuproptosis 38006800 Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C–C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. cuproptosis-related genes
MAP2K1 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
MAP2K1 cuproptosis 38348451 Components of the MAPK signaling pathway. MAPK pathways can be activated in response to stress and may contribute to cell death mechanisms. CRGs in the cuproptosis pathway
MAP2K1 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
MAP2K1 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MAP2K1 GO:0000165,GO:0004672,GO:0004674,GO:0004708,GO:0004708,GO:0004712,GO:0004713,GO:0005078,GO:0005515,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005783,GO:0005794,GO:0005815,GO:0005829,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0006935,GO:0007165,GO:0007507,GO:0008285,GO:0010628,GO:0021697,GO:0030182,GO:0030216,GO:0030295,GO:0030878,GO:0032872,GO:0035987,GO:0043539,GO:0044342,GO:0045893,GO:0048009,GO:0048538,GO:0048679,GO:0048870,GO:0050772,GO:0060020,GO:0060324,GO:0060440,GO:0060502,GO:0060674,GO:0060711,GO:0070371,GO:0070374,GO:0071902,GO:0090170,GO:0090398,GO:0097110,GO:0106310,GO:1903226,GO:2000641

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP2K1 hsa:5604 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa01522 Endocrine resistance - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04140 Autophagy - animal - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04148 Efferocytosis - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04210 Apoptosis - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04218 Cellular senescence - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04510 Focal adhesion - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04540 Gap junction - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04720 Long-term potentiation - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04730 Long-term depression - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04916 Melanogenesis - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04929 GnRH secretion - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04934 Cushing syndrome - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05010 Alzheimer disease - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05034 Alcoholism - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05132 Salmonella infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05135 Yersinia infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05160 Hepatitis C - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05161 Hepatitis B - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05164 Influenza A - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05200 Pathways in cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05210 Colorectal cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05213 Endometrial cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05214 Glioma - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05215 Prostate cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05216 Thyroid cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05218 Melanoma - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05219 Bladder cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05224 Breast cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05226 Gastric cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
MAP2K1 hsa:5604 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ARRB2 MAP2K1 11226259 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K1 KSR2 12975377 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K1 BRAF 15485920 23180781 physical association gst pull down InnateDB
MAP2K1 MAP3K1 10969079 12456688 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
MAP2K1 PAK1 23180781 9351825 phosphorylation reaction protein kinase assay InnateDB
KSR1 MAP2K1 18332145 23180781 physical association anti tag coimmunoprecipitation InnateDB
BRAP MAP2K1 18332145 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K1 MAPK3 10748187 11134045 11242034 21071413 23180781 23331499 8226933 9733512 stimulation,physical association pull down InnateDB,SignaLink,SignaLink
MAP2K1 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK3 MAP2K1 10748187 18988627 21071413 23331499 8226933 8626767 9006895 9922370 interaction type N/A SignaLink,SignaLink
BRAF MAP2K1 16810323 16888650 18988627 21071413 23331499 7731720 7835430 8157000 8394352 8621729 stimulation N/A SignaLink,SignaLink
MAP3K8 MAP2K1 23331499 8631303 stimulation N/A SignaLink,SignaLink
MAP2K1 MAPK1 10757792 11242034 11266467 12697810 21071413 23331499 stimulation N/A SignaLink,SignaLink
RAF1 MAP2K1 10757792 11242034 11604401 15485920 16093354 18988627 21071413 23331499 7731720 8157000 8394352 8621729 stimulation N/A SignaLink,SignaLink
MAP3K2 MAP2K1 11343802 23331499 stimulation N/A SignaLink,SignaLink
PAK1 MAP2K1 23331499 9351825 stimulation N/A SignaLink
PEBP1 MAP2K1 10490027 10757792 23331499 stimulation N/A SignaLink
WDR83 MAP2K1 15118098 23331499 stimulation N/A SignaLink
LAMTOR3 MAP2K1 11266467 15547943 23331499 9733512 stimulation N/A SignaLink
MAP2K1 GLI1 16424016 23331499 stimulation N/A SignaLink
MAP2K1 GLIS2 16424016 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB10 MAP2K1 20005715 interaction type N/A PSP
MAPK8IP3 MAP2K1 20005715 interaction type N/A PSP
LAMTOR3 MAP2K1 20005715 interaction type N/A PSP,SignaLink
TRAF3 MAP2K1 18988627 20005715 8626767 interaction type N/A PSP,SignaLink
GRB10 MAP2K1 18988627 20005715 20005715 21071413 9553107 9553107 9553107 9553107 N/A N/A SignaLink
MAPK8IP3 MAP2K1 10523642 11044439 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP2K1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 MAP2K1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MAP2K1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MAP2K1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 MAP2K1 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP2K1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MAP2K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 MAP2K1 20299489 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000F0F49 MAP2K1 20065103 21179471 rna interference,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS000007D64A MAP2K1 23092882 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000F0F49 MAP2K1 20065103 21179471 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000EED18 MAP2K1 20299489 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007D64A MAP2K1 23092882 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 MAP2K1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E0AEA MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000031BC7D MAP2K1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD MAP2K1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00002C7B2B MAP2K1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000027352D MAP2K1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001F5B39 MAP2K1 24960059 25416803 26609480 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000044FD7 MAP2K1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000029D9F1 MAP2K1 24960059 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000045B99E MAP2K1 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RAF1 MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CHEK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
MAPK3 MAP2K1 22135298 phosphorylation N/A PhosphoSite
CDK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
ARAF MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PDPK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
MAPK1 MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
CDK5 MAP2K1 22135298 phosphorylation N/A PhosphoSite
MAP2K1 MAPK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K1 MAPK3 22135298 phosphorylation N/A PhosphoSite
MAP2K1 TAL1 22135298 phosphorylation N/A PhosphoSite
MAP2K1 GSK3B 22135298 phosphorylation N/A PhosphoSite
MAP2K1 KRT8 22135298 phosphorylation N/A PhosphoSite
MAP2K1 HSF1 22135298 phosphorylation N/A PhosphoSite
MAP2K1 RAF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PAK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
BRAF MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
BLVRA MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 BLVRA 25361965 interaction type N/A PTMCode2
HSPA8 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 HSPA8 25361965 interaction type N/A PTMCode2
YWHAE MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 YWHAE 25361965 interaction type N/A PTMCode2
MAP2K1 BRAF 25361965 interaction type N/A PTMCode2
MAP2K1 MAP3K8 25361965 interaction type N/A PTMCode2
MAP2K1 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 HRAS 25361965 interaction type N/A PTMCode2
HRAS MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 CFLAR 25361965 interaction type N/A PTMCode2
CFLAR MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 TRAF3 25361965 interaction type N/A PTMCode2
TRAF3 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 PLK3 25361965 interaction type N/A PTMCode2
PLK3 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 HSPA1A 25361965 interaction type N/A PTMCode2
HSPA1A MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 ARAF 25361965 interaction type N/A PTMCode2
MAP2K1 MYC 25361965 interaction type N/A PTMCode2
MYC MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 GRB10 25361965 interaction type N/A PTMCode2
GRB10 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP2K1 25361965 interaction type N/A PTMCode2
ELK1 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 ELK1 25361965 interaction type N/A PTMCode2
EGFR MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 EGFR 25361965 interaction type N/A PTMCode2
MAPK14 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 MAPK14 25361965 interaction type N/A PTMCode2
KSR1 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 KSR1 25361965 interaction type N/A PTMCode2
PEBP4 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 PEBP4 25361965 interaction type N/A PTMCode2
PEBP1 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 PEBP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 MAP2K1 20179161 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct
UBE2I MAP2K1 25348397 N/A physical interaction ComPPI
PLEKHF2 MAP2K1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPA8 MAP2K1 17979178 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRIB3 MAP2K1 15299019 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TRAF6 MAP2K1 14525934 16313339 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VCP MAP2K1 25348397 N/A physical interaction ComPPI
CASP9 MAP2K1 12792650 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
WDR83 MAP2K1 25348397 N/A physical interaction ComPPI
DCP1A MAP2K1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERBB2 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PAK1 MAP2K1 25348397 N/A in vitro,in vivo ComPPI
VAV1 MAP2K1 25348397 N/A physical interaction ComPPI
MAPK1 MAP2K1 11134045 11352917 11741894 11823456 12594221 14525934 17255949 23241949 24234451 25348397 8157000 phosphorylation reaction,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HRAS MAP2K1 14525934 25348397 7969158 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TGFBR2 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPK8 MAP2K1 25348397 N/A physical interaction ComPPI
PTPN11 MAP2K1 25348397 N/A physical interaction ComPPI
SRC MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
GRB10 MAP2K1 14525934 25348397 9553107 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
FBXW7 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ARAF MAP2K1 14525934 17979178 24234451 24746704 25348397 26496610 7731720 8157000 8394352 8621729 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
MAPK3 MAP2K1 10748187 14525934 19197339 24234451 25348397 8226933 8626767 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD2 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
EP300 MAP2K1 11278389 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK14 MAP2K1 12697810 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NFE2L2 MAP2K1 25348397 N/A physical interaction ComPPI
CPNE1 MAP2K1 12522145 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CPNE4 MAP2K1 12522145 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ODC1 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
YWHAB MAP2K1 17979178 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
YWHAZ MAP2K1 17979178 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3CA MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
APC MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CDH1 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BTRC MAP2K1 24211253 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
BUB1 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CALR MAP2K1 22752157 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
HSPA1A MAP2K1 17979178 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HSPA1B MAP2K1 25348397 N/A physical interaction,tandem affinity purification ComPPI
MSH6 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 MYC 14525934 24234451 25348397 26496610 7957875 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP2K1 RPS6KA2 25348397 N/A in vitro ComPPI
MAP2K1 TRAF3 14525934 25348397 8626767 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K1 MAP3K4 14525934 25348397 9841871 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K1 LAMTOR3 14525934 25348397 9733512 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAP2K1 RPS6KA4 10806207 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K1 PEBP1 10757792 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K1 TRIB1 14525934 15299019 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
MAP2K1 PEBP4 19197339 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
MAP2K1 MAPK8IP3 10523642 11044439 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K1 KSR2 12975377 14525934 24234451 25348397 27086506 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP2K1 PARVA 25348397 N/A in vivo ComPPI
MAP2K1 EGFR 12556561 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K1 PRKCZ 11535599 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K1 ELK1 10716983 10997882 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K1 CDK5 11684694 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K1 KSR1 11741534 11940661 14525934 15520859 17979178 24234451 25348397 26496610 27086506 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MAP2K1 BIRC6 14525934 18329369 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
MAP2K1 BRAF 14525934 16810323 17979178 23934108 24234451 24746704 25155755 25348397 25437913 25600339 26496610 7731720 8157000 8394352 8621729 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescence technology,molecular sieving,pull down,surface plasmon resonance,phosphorylation reaction,physical interaction,kinase homogeneous time resolved fluorescence,protein kinase assay,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MAP2K1 RAF1 11604401 14525934 16093354 17724343 17979178 19197339 23934108 24234451 24746704 25155755 25348397 26496610 7731720 8157000 8394352 8621729 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,biochemical,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MAP2K1 LAMTOR2 25348397 N/A physical interaction ComPPI
MAP2K1 MAP3K8 12832462 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MAP2K1 MAP3K1 17110930 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP2K1 ARRB2 25348397 N/A physical interaction ComPPI
MAP2K1 ELAVL1 25348397 N/A physical interaction ComPPI
MAP2K1 BRAP 25348397 N/A physical interaction ComPPI
MAP2K1 LSP1 25348397 N/A physical interaction ComPPI
MAP2K1 YWHAE 17979178 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAP2K1 HNRNPD 25348397 N/A physical interaction ComPPI
MAP2K1 YAP1 24211253 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
MAP2K1 PSMD10 24234451 24338975 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 BANP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAP2K1 PPARG 25348397 N/A physical interaction ComPPI
MAP2K1 NUFIP1 25348397 N/A physical interaction ComPPI
MAP2K1 DGUOK 25348397 N/A physical interaction ComPPI
MAP2K1 PDLIM5 25348397 N/A physical interaction ComPPI
MAP2K1 PLIN3 25348397 N/A physical interaction ComPPI
MAP2K1 RPE 25348397 N/A physical interaction ComPPI
MAP2K1 POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAP2K1 TCTN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAP2K1 THOC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 SKA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 ZNF277 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 RBM33 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 FGB 25348397 N/A physical interaction ComPPI
MAP2K1 RNASE9 25348397 N/A physical interaction ComPPI
MAP2K1 TRIM25 25348397 N/A physical interaction ComPPI
MAP2K1 KAT7 25348397 N/A physical interaction ComPPI
MAP2K1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAP2K1 VRK2 20679487 24234451 25348397 physical association coimmunoprecipitation,pull down ComPPI,IntAct
MAP2K1 AURKA 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 BAX 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 BMPR1A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 CDKN2A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 PDGFRL 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 PTPRJ 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 STK11 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP2K2 MAP2K1 25348397 N/A physical interaction ComPPI
IQGAP1 MAP2K1 25348397 N/A physical interaction ComPPI
PKM MAP2K1 25348397 N/A protein kinase assay ComPPI
PRKCI MAP2K1 10848576 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PLK3 MAP2K1 14525934 15021912 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CFLAR MAP2K1 25348397 N/A anti tag coimmunoprecipitation ComPPI
HSCB MAP2K1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
BLVRA MAP2K1 18463290 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 MAP2K1 12697810 14525934 8226933 9733512 N/A experimental interaction detection HPRD
ADARB1 MAP2K1 10786836 27898060 9832507 N/A N/A OmniPath
MAP2K1 RAD54L2 19917248 21660693 27898060 N/A N/A OmniPath
CDK5 MAP2K1 11684694 18691976 27898060 inhibition N/A OmniPath
EGFR MAP2K1 12556561 15531749 27898060 stimulant N/A OmniPath
ARRB2 MAP2K1 11226259 27898060 N/A N/A OmniPath
MAP2K1 ARRB2 11226259 27898060 28169830 stimulant N/A OmniPath
MAP3K8 MAP2K1 12832462 15466476 16291755 17906627 18187448 27898060 8131746 8631303 9351825 stimulant N/A OmniPath
MAP2K1 MAP3K1 10969079 12456688 14500727 17110930 18982020 27898060 9804171 9878570 N/A N/A OmniPath
MAP3K1 MAP2K1 10969079 12456688 14500727 17110930 18982020 27898060 9804171 9878570 stimulant N/A OmniPath
MAP2K1 CASP9 12792650 18669648 27898060 N/A N/A OmniPath
MAP2K1 KSR2 12975377 27898060 N/A N/A OmniPath
MAP3K2 MAP2K1 11343802 27898060 stimulant N/A OmniPath
BRAF MAP2K1 15485920 16810323 16888650 17979178 18039929 18332145 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27898060 7731720 8157000 8394352 8413257 8621729 stimulant N/A OmniPath
MAP2K1 BRAF 15485920 16810323 16888650 17979178 18332145 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27898060 7731720 8157000 8394352 8413257 8621729 N/A N/A OmniPath
ATR MAP2K1 27898060 7873542 N/A N/A OmniPath
PDPK1 MAP2K1 15175348 27898060 stimulant N/A OmniPath
MAP2K1 MAPK6 16251502 27898060 stimulant N/A OmniPath
PEBP1 MAP2K1 10490027 1075779 10757792 27898060 stimulant N/A OmniPath
MAP2K1 IRS1 11160134 27898060 inhibition N/A OmniPath
MAP2K1 RPS6KA4 10806207 16964243 18691976 19651622 20068231 27898060 stimulant N/A OmniPath
MAPK3 MAP2K1 10748187 11134045 12644307 19058874 19197339 27898060 8226933 8626767 9006895 9677429 9733512 stimulant N/A OmniPath
MAP2K1 MAPK3 10748187 11134045 12270934 12644307 15951569 17081983 17192257 17389395 17906627 18083107 18669648 18691976 18983981 19058874 19197339 19369195 19494114 19534553 19690332 27898060 8226933 8626767 9006895 9677429 9733512 stimulant N/A OmniPath
CDK1 MAP2K1 11684694 12506122 15466476 27898060 7624324 7873542 7936666 8114697 inhibition N/A OmniPath
RAF1 MAP2K1 10359597 10409742 10757792 10958680 11435472 11604401 11684694 1326789 14636584 15485920 15866172 16093354 17053865 17192257 17724343 17979178 18337766 18556463 18691976 19058874 19197339 20212043 20956560 21336309 23934108 24746704 26496610 27898060 7731720 8131746 8157000 8394352 8621729 9311917 9677429 stimulant N/A OmniPath
MAP2K1 GLI1 16424016 27898060 stimulant N/A OmniPath
MAPK1 MAP2K1 10567369 10757792 11134045 11266467 11279118 11352917 11435472 11522288 11522789 11741894 11823456 11971971 12270934 12388769 12594221 12697810 12788955 14993270 15466476 15935618 16153436 16484222 16497976 17016520 17255949 17389395 18452278 18578522 18669648 18691976 18707149 19058874 19415658 19651622 19901323 20068231 21144847 21336309 21675959 21842857 23241949 24623782 27898060 7624324 7873542 8039496 8157000 9166761 9351825 inhibition,stimulant N/A OmniPath
MAP2K1 MAPK1 10567369 10757792 11134045 11251083 11266467 11279118 11352917 11435472 11522288 11522789 11741894 11823456 11971971 12270934 12388769 12594221 12644307 12697810 12788955 14993270 15466476 15592455 15935618 15951569 16094384 16153436 16484222 16497976 16887817 17016520 17081983 17192257 17255949 17389395 17906627 18083107 18452278 18578522 18669648 18691976 18707149 19053285 19058874 19369195 19415658 19494114 19534553 19651622 19690332 19901323 20068231 21144847 21336309 21675959 21842857 23241949 24623782 27898060 7624324 7873542 8039496 8157000 8226933 9166761 9351825 stimulant N/A OmniPath
PAK1 MAP2K1 11684694 12609978 12876277 14993270 16129686 27898060 7873542 9351825 9416003 stimulant N/A OmniPath
MAP2K1 PPARG 17101779 18596912 21690289 27898060 inhibition N/A OmniPath
PPP2CA MAP2K1 1716348 20626350 27898060 inhibition N/A OmniPath
MAP2K1 GSK3B 11035810 15020233 16039586 27898060 stimulant N/A OmniPath
ARAF MAP2K1 17979178 18039929 24114843 26496610 27898060 7731720 8157000 8394352 8621729 stimulant N/A OmniPath
MAP2K1 RBL1 12006580 27898060 N/A N/A OmniPath
BRAP MAP2K1 18332145 27898060 N/A N/A OmniPath
MAP2K1 KSR1 10409742 11741534 11940661 15090600 15520859 17979178 18332145 21144847 26496610 26549023 27898060 N/A N/A OmniPath
MAP2K1 TAL1 11904294 27898060 inhibition N/A OmniPath
LAMTOR3 MAP2K1 11266467 15547943 27898060 9733512 stimulant N/A OmniPath
WDR83 MAP2K1 15118098 27898060 stimulant N/A OmniPath
PPP2CB MAP2K1 1716348 27898060 N/A N/A OmniPath
MAP2K1 PARVA 15353548 18669648 18691976 19651622 19664995 20068231 20166139 27898060 N/A N/A OmniPath

Visualization










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