GENE：RASGRP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RASGRP1 |
| FullNmae | RAS guanyl releasing protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9878 |
| EnsembleID | ENSG00000172575 |
| Uniprot | O95267 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RASGRP1 | lysosomal_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RASGRP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RASGRP1 | GO:0000139,GO:0001934,GO:0001934,GO:0002437,GO:0005085,GO:0005085,GO:0005085,GO:0005509,GO:0005789,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0007165,GO:0007265,GO:0007265,GO:0008270,GO:0008289,GO:0016020,GO:0019992,GO:0030101,GO:0030154,GO:0031210,GO:0032252,GO:0032725,GO:0032729,GO:0032760,GO:0032825,GO:0033089,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042802,GO:0043303,GO:0043406,GO:0043547,GO:0043547,GO:0045954,GO:0046330,GO:0046579,GO:0047496,GO:0070372,GO:0070374,GO:0090630,GO:0090630 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RASGRP1 | hsa:10125 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| RASGRP1 | hsa:10125 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| RASGRP1 | hsa:10125 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| RASGRP1 | hsa:10125 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| RASGRP1 | hsa:10125 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| RASGRP1 | hsa:10125 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAF1 | RASGRP1 | 10567412 10807788 11532940 12419216 12566895 12782630 14764585 15184873 15516985 15567848 16227978 16488589 17496910 19289794 19565474 19615955 21102635 24027568 26192618 9069260 | interaction type | N/A | ACSN |
| RASGRP1 | HRAS | 10777492 10807788 10835426 10934204 11221888 12782630 14764585 15184873 17283063 17496910 24027568 26192618 29145629 | interaction type,enzymatic reaction | inferred by curator | ACSN,Reactome |
| RASGRP1 | DGKZ | 11257115 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RASGRP1 | KRAS | 10777492 10835426 10934204 11221888 17283063 29145629 | enzymatic reaction | inferred by curator | Reactome |
| RASGRP1 | NRAS | 10777492 10835426 10934204 11221888 17283063 29145629 | enzymatic reaction | inferred by curator | Reactome |
| PRKCB | RASGRP1 | 12904771 15899849 23109003 9582122 | chemical activation reaction | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | RASGRP1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | RASGRP1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | RASGRP1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | RASGRP1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | RASGRP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | RASGRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RASGRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RASGRP1 | 18396012 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | RASGRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RASGRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RASGRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RASGRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | RASGRP1 | 20483747 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000009262D | RASGRP1 | 18591254 20483747 22473208 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | RASGRP1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001BCAC5 | RASGRP1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D5659 | RASGRP1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | RASGRP1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076995 | RASGRP1 | 25416803 26794609 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00003FA24D | RASGRP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000010BD8D | RASGRP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKCQ | RASGRP1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| HRAS | RASGRP1 | 25361965 | interaction type | N/A | PTMCode2 |
| RASGRP1 | HRAS | 25361965 | interaction type | N/A | PTMCode2 |
| RASGRP1 | DGKZ | 25361965 | interaction type | N/A | PTMCode2 |
| DGKZ | RASGRP1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HRAS | RASGRP1 | 14525934 25348397 9582122 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| DGKZ | RASGRP1 | 11257115 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| VHL | RASGRP1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RASGRP1 | PPM1B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RASGRP1 | ABCB8 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCQ | RASGRP1 | 15899849 27898060 | stimulant | N/A | OmniPath |
| DGKZ | RASGRP1 | 11257115 27898060 | N/A | N/A | OmniPath |