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GENE：ADORA2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADORA2B
FullNmae adenosine A2b receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:264
EnsembleID ENSG00000170425
Uniprot P29275

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADORA2B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADORA2B GO:0001609,GO:0001973,GO:0002882,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0007189,GO:0007190,GO:0010575,GO:0010753,GO:0019934,GO:0031668,GO:0032722,GO:0032755,GO:0042311,GO:0043303,GO:0043306,GO:0060087,GO:0098685,GO:0098793,GO:0098978,GO:0099171

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ADORA2B hsa:136 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
ADORA2B hsa:136 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ADORA2B hsa:136 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
ADORA2B hsa:136 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ADORA2B hsa:136 path:hsa05034 Alcoholism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ADORA2B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 ADORA2B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ADORA2B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ADORA2B 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A ADORA2B 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
TP73 ADORA2B 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 ADORA2B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ADORA2B 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ADORA2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000330617 ADORA2B 20388705 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000330617 ADORA2B 20388705 21572407 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00001B341F ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 ADORA2B 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004203C ADORA2B 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000153377 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 ADORA2B 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ADORA2B DCC 25361965 interaction type N/A PTMCode2
DCC ADORA2B 25361965 interaction type N/A PTMCode2
ADORA2B SLC9A3R2 25361965 interaction type N/A PTMCode2
SLC9A3R2 ADORA2B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TPD52L2 ADORA2B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SLC9A3R2 ADORA2B 12080047 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NTN1 ADORA2B 11048721 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ADORA2B DCC 11048721 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
ADORA2B EZR 12080047 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ADORA2B ADA 11125033 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ADORA2B ZNF267 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct

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