GENE：AKT3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AKT3 |
| FullNmae | AKT serine/threonine kinase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:393 |
| EnsembleID | ENSG00000117020 |
| Uniprot | Q9Y243 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AKT3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AKT3 | apoptosis | 33951290 | And subsequent study indicated that the over-expressed AKT3 could rescue the increased cell apoptosis rate induced by the knockdown of circHIPK3. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AKT3 | GO:0000002,GO:0001938,GO:0004672,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007165,GO:0016020,GO:0018105,GO:0032008,GO:0035556,GO:0043536,GO:0045766,GO:0045793,GO:0048854,GO:0048873,GO:0090050,GO:0106310,GO:1905564,GO:1905653,GO:2000773 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AKT3 | hsa:10000 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04931 | Insulin resistance - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05162 | Measles - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05214 | Glioma - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
| AKT3 | hsa:10000 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| APPL1 | AKT3 | 10490823 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TCL1A | AKT3 | 11707444 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PHLPP2 | AKT3 | 17386267 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PHLPP1 | AKT3 | 17386267 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLEKHO1 | AKT3 | 17942896 23180781 | physical association | pull down | InnateDB |
| PPP2CA | AKT3 | 18160256 23180781 | dephosphorylation reaction | phosphatase assay | InnateDB |
| PRKCZ | AKT3 | 12162751 23180781 | physical association | anti tag coimmunoprecipitation,two hybrid | InnateDB |
| CASP3 | AKT3 | 17544405 23180781 | cleavage reaction | enzymatic study,protease assay | InnateDB |
| PTEN | AKT3 | 10644997 23331499 | stimulation | N/A | SignaLink |
| AKT3 | BAD | 15023346 23109003 | inhibition | N/A | SignaLink |
| AKT3 | GSK3B | 12851486 15023346 23109003 | inhibition | N/A | SignaLink |
| AKT3 | FOXO3 | 15023346 23109003 | inhibition | N/A | SignaLink |
| AKT3 | CDKN1A | 12851486 15023346 23109003 | inhibition | N/A | SignaLink |
| PTPA | AKT3 | 16227604 19405949 23109003 | inhibition | N/A | SignaLink |
| AKT3 | PRKCQ | 11410591 23109003 | chemical activation reaction | N/A | SignaLink |
| AKT3 | MAP3K8 | 12138205 23109003 | chemical activation reaction | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | AKT3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | AKT3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | AKT3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | AKT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | AKT3 | 19296470 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000171CD1 | AKT3 | 23233752 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000298BA3 | AKT3 | 22262409 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00003380CC | AKT3 | 19296470 24244539 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000171CD1 | AKT3 | 21572407 23233752 23592263 25416803 | mrna cleavage,inhibition | clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000298BA3 | AKT3 | 22262409 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000272A3D | AKT3 | 20371350 25416803 28160548 | mrna cleavage,inhibition | nucleotide sequence identification,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000050CCE0 | AKT3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000475586 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015A0D9 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000913AC | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F6E49 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | AKT3 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | AKT3 | 21572407 23592263 25416803 28254819 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000285DCB | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CF1D2 | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000153377 | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019D79B | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000214763 | AKT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001123BD | AKT3 | 25416803 28365400 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000076995 | AKT3 | 25416803 26482618 26512921 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00002B3783 | AKT3 | 25416803 27421659 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PDPK1 | AKT3 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| AKT3 | AGO2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AKT3 | TBX3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AKT3 | BRAF | 22135298 | phosphorylation | N/A | PhosphoSite |
| AKT3 | PDPK1 | 25361965 | interaction type | N/A | PTMCode2 |
| AKT3 | PRKCZ | 25361965 | interaction type | N/A | PTMCode2 |
| PRKCZ | AKT3 | 25361965 | interaction type | N/A | PTMCode2 |
| TCL1A | AKT3 | 25361965 | interaction type | N/A | PTMCode2 |
| AKT3 | TCL1A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TCL1A | AKT3 | 11707444 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| HSP90AB1 | AKT3 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCD | AKT3 | 12162751 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CASP3 | AKT3 | 17544405 24234451 25241761 25348397 | cleavage reaction,physical association | physical interaction,enzymatic study,proximity ligation assay | ComPPI,IntAct |
| GSK3B | AKT3 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | AKT3 | 24234451 25036637 25348397 | physical association | physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| PDPK1 | AKT3 | 12162751 14525934 25348397 9512493 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| EIF4EBP1 | AKT3 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCZ | AKT3 | 12162751 14525934 24234451 25241761 25348397 9305920 9512493 | physical association | experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| AKT3 | TSC2 | 12167664 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| AKT3 | NEDD4 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | TTC3 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | PLEKHO1 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | RPE | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | AKT1 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | PIANP | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | FKBP5 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | CDC37 | 12176997 24234451 25036637 25348397 | physical association | coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| AKT3 | SNX8 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | TOX2 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | PRMT6 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | PPP2CA | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | CCNA2 | 24234451 24670654 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| AKT3 | NUDCD1 | 24234451 25036637 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| PKM | AKT3 | 25348397 | N/A | protein kinase assay | ComPPI |
| NEDD4L | AKT3 | 25348397 | N/A | physical interaction | ComPPI |
| AKT3 | NOS3 | 24379783 27898060 | stimulant | N/A | OmniPath |
| PTEN | AKT3 | 10644997 27898060 | inhibition,stimulant | N/A | OmniPath |
| PRKCD | AKT3 | 12162751 27898060 | N/A | N/A | OmniPath |
| AKT3 | CHUK | 19609947 27898060 | stimulant | N/A | OmniPath |
| AKT3 | CREB1 | 27898060 9829964 | stimulant | N/A | OmniPath |
| AKT3 | AKT1S1 | 17440074 27898060 | inhibition | N/A | OmniPath |
| TCL1A | AKT3 | 10983986 11707444 27898060 | stimulant | N/A | OmniPath |
| AKT3 | FOXO3 | 19188143 27898060 | inhibition | N/A | OmniPath |
| CASP3 | AKT3 | 17544405 25241761 27898060 | N/A | N/A | OmniPath |
| AKT3 | CASP3 | 17544405 25241761 27898060 | N/A | N/A | OmniPath |
| AKT3 | CASP9 | 27898060 9812896 | inhibition | N/A | OmniPath |
| AKT3 | BRAF | 10869359 11293329 19933846 27898060 | inhibition | N/A | OmniPath |
| TRAF6 | AKT3 | 19713527 27898060 | stimulant | N/A | OmniPath |
| AKT3 | BAD | 10949026 27898060 | inhibition,stimulant | N/A | OmniPath |
| PDPK1 | AKT3 | 10208883 12162751 23603119 27898060 9512493 | stimulant | N/A | OmniPath |
| HSPB6 | AKT3 | 18948619 27898060 | stimulant | N/A | OmniPath |
| AKT3 | AGO2 | 18476811 21071408 23603119 26443379 27898060 | stimulant | N/A | OmniPath |
| AKT3 | STK4 | 23431053 27898060 | inhibition | N/A | OmniPath |
| PRKCZ | AKT3 | 12162751 25241761 27898060 9305920 9512493 | inhibition,stimulant | N/A | OmniPath |
| AKT3 | PRKCZ | 12162751 25241761 27898060 9305920 9512493 | N/A | N/A | OmniPath |
| AKT3 | STK3 | 20231902 27898060 | inhibition | N/A | OmniPath |
| HSPB2 | AKT3 | 18266962 27898060 | stimulant | N/A | OmniPath |
| PHLPP1 | AKT3 | 17386267 19261608 27898060 | inhibition | N/A | OmniPath |
| AKT3 | PHLPP1 | 17386267 27898060 | N/A | N/A | OmniPath |
| PPP2CA | AKT3 | 18160256 27898060 | inhibition | N/A | OmniPath |
| AKT3 | GSK3B | 23552696 27898060 | inhibition,stimulant | N/A | OmniPath |
| AKT3 | HSPB1 | 19593530 27898060 | inhibition | N/A | OmniPath |
| AKT3 | APPL1 | 10490823 27898060 | N/A | N/A | OmniPath |
| PLEKHO1 | AKT3 | 17942896 27898060 | N/A | N/A | OmniPath |
| MTCP1 | AKT3 | 10983986 27898060 | stimulant | N/A | OmniPath |
| PHLPP2 | AKT3 | 17386267 19261608 27898060 | inhibition | N/A | OmniPath |
| AKT3 | PHLPP2 | 17386267 27898060 | N/A | N/A | OmniPath |
| ALK | AKT3 | 27898060 9512493 | N/A | N/A | OmniPath |
| AKT3 | POU5F1 | 23041284 27898060 | stimulant | N/A | OmniPath |
| PPP2CB | AKT3 | 18160256 27898060 | inhibition | N/A | OmniPath |
| AKT3 | TBX3 | 25595898 27898060 | stimulant | N/A | OmniPath |
| FAM107A | AKT3 | 10983986 27898060 | stimulant | N/A | OmniPath |