GENE：ENPP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ENPP1 |
| FullNmae | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3356 |
| EnsembleID | ENSG00000197594 |
| Uniprot | P22413 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ENPP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ENPP1 | GO:0003676,GO:0004115,GO:0004527,GO:0004528,GO:0004528,GO:0004528,GO:0004551,GO:0004551,GO:0005044,GO:0005158,GO:0005509,GO:0005515,GO:0005524,GO:0005615,GO:0005765,GO:0005886,GO:0005886,GO:0005886,GO:0006091,GO:0006796,GO:0006897,GO:0006955,GO:0008270,GO:0009143,GO:0009143,GO:0009986,GO:0009986,GO:0010035,GO:0010467,GO:0016020,GO:0016323,GO:0016791,GO:0030247,GO:0030282,GO:0030308,GO:0030318,GO:0030500,GO:0030500,GO:0030502,GO:0030505,GO:0030505,GO:0030643,GO:0030730,GO:0031953,GO:0032869,GO:0033198,GO:0036219,GO:0036221,GO:0042803,GO:0045599,GO:0045599,GO:0045719,GO:0046034,GO:0046034,GO:0046034,GO:0046325,GO:0046627,GO:0047429,GO:0047693,GO:0050427,GO:0050656,GO:0055062,GO:0090305,GO:0106177,GO:1990787 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ENPP1 | hsa:5167 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa00500 | Starch and sucrose metabolism - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa00740 | Riboflavin metabolism - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa00760 | Nicotinate and nicotinamide metabolism - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa00770 | Pantothenate and CoA biosynthesis - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ENPP1 | hsa:5167 | path:hsa01232 | Nucleotide metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ENPP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA3 | ENPP1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ENPP1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ENPP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ENPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000D0BB4 | ENPP1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000078918 | ENPP1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | ENPP1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000204177 | ENPP1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | ENPP1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024DFCE | ENPP1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | ENPP1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | ENPP1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | ENPP1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | ENPP1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EIF2B2 | ENPP1 | 25348397 | N/A | physical interaction | ComPPI |
| CD81 | ENPP1 | 24234451 25348397 30024968 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PSMA1 | ENPP1 | 25348397 | N/A | physical interaction | ComPPI |
| SQSTM1 | ENPP1 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FANCE | ENPP1 | 25348397 | N/A | physical interaction | ComPPI |
| INSR | ENPP1 | 10615944 11289049 14525934 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo | ComPPI,HPRD,IntAct |
| PSMB1 | ENPP1 | 25348397 | N/A | physical interaction | ComPPI |
| PSMD12 | ENPP1 | 25348397 | N/A | physical interaction | ComPPI |
| USP2 | ENPP1 | 25348397 | N/A | physical interaction | ComPPI |
| ENPP1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ENPP1 | BZW1 | 25348397 | N/A | physical interaction | ComPPI |
| ENPP1 | PON2 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1A | ENPP1 | 19083193 27898060 | stimulant | N/A | OmniPath |
| HSPA1B | ENPP1 | 19083193 27898060 | stimulant | N/A | OmniPath |
| ENPP1 | INSR | 10615944 11289049 27898060 | inhibition | N/A | OmniPath |