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GENE：GREM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GREM1
FullNmae gremlin 1, DAN family BMP antagonist
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2001
EnsembleID ENSG00000166923
Uniprot O60565

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GREM1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GREM1 GO:0000902,GO:0002042,GO:0002092,GO:0003337,GO:0005125,GO:0005515,GO:0005615,GO:0005615,GO:0007165,GO:0007267,GO:0008284,GO:0009887,GO:0009954,GO:0009986,GO:0010717,GO:0016015,GO:0030199,GO:0030297,GO:0030308,GO:0030326,GO:0030502,GO:0030514,GO:0030514,GO:0032331,GO:0033689,GO:0036122,GO:0036122,GO:0036122,GO:0038098,GO:0042803,GO:0043066,GO:0043184,GO:0045668,GO:0045668,GO:0045766,GO:0045892,GO:0045944,GO:0046851,GO:0048018,GO:0048018,GO:0048263,GO:0051893,GO:0051973,GO:0055007,GO:0060173,GO:0060379,GO:0060676,GO:0062023,GO:0090027,GO:0090090,GO:0090190,GO:0090291,GO:1900086,GO:1900155,GO:1900158,GO:1901224,GO:2000273

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GREM1 hsa:26585 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GREM1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 GREM1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 GREM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 GREM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GREM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GREM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003003B4 GREM1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB GREM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001A405B GREM1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 GREM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 GREM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 GREM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F GREM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C GREM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 GREM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F GREM1 25416803 27910957 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
GREM1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 GREM1 25361965 interaction type N/A PTMCode2
YWHAH GREM1 25361965 interaction type N/A PTMCode2
GREM1 YWHAH 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP12-2 GREM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MDFI GREM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KDR GREM1 20660291 24234451 25348397 physical association cross-linking study,surface plasmon resonance,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,IntAct
YWHAH GREM1 14525934 16545136 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
BMP2 GREM1 14525934 15064755 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD

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