Gene Information gene info

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GENE：TLR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLR1
FullNmae toll like receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11847
EnsembleID ENSG00000174125
Uniprot Q15399

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TLR1 GO:0002224,GO:0002224,GO:0002224,GO:0004888,GO:0005515,GO:0005794,GO:0005886,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0016020,GO:0030670,GO:0032755,GO:0032757,GO:0032760,GO:0034137,GO:0035354,GO:0035354,GO:0035354,GO:0035663,GO:0035663,GO:0038023,GO:0042116,GO:0042495,GO:0042802,GO:0043235,GO:0045087,GO:0045121,GO:0050135,GO:0061809,GO:0071723,GO:0071727,GO:0071727

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLR1 hsa:7096 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TLR1 hsa:7096 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR10 TLR1 15728506 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR1 TLR4 11932926 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR1 TLR2 12077222 16848791 22673208 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TLR1 FLNA 16482509 23180781 physical association two hybrid InnateDB
TLR1 DHX36 16482509 23180781 physical association two hybrid InnateDB
TLR1 HSPD1 16482509 23180781 physical association two hybrid InnateDB
TRAP1 TLR1 16482509 23180781 physical association two hybrid InnateDB
TLR1 ECHS1 16482509 23180781 physical association two hybrid InnateDB
TLR1 HSP90B1 11584270 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR1 MYD88 19717524 22673208 23180781 physical association affinity chromatography technology,two hybrid,pull down InnateDB
TLR1 TIRAP 19717524 22673208 23180781 physical association affinity chromatography technology,pull down InnateDB
TLR1 BCL6 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TLR1 20348427 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 TLR1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TLR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 TLR1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 TLR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
HSP90B1 TLR1 11584270 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TRAP1 TLR1 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TLR2 TLR1 12077222 14525934 23155421 24234451 25348397 physical association experimental interaction detection,fluorescent resonance energy transfer,physical interaction,tox-r dimerization assay,in vivo ComPPI,HPRD,IntAct
TLR4 TLR1 11932926 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIGLEC10 TLR1 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR1 TLR5 12600829 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TLR1 TLR9 12600829 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TLR1 HSPD1 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TLR1 TLR10 14525934 15728506 23155421 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,tox-r dimerization assay,in vivo ComPPI,HPRD,IntAct
TLR1 DHX36 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TLR1 TLR6 23155421 24234451 25348397 physical association physical interaction,tox-r dimerization assay ComPPI,IntAct
TLR1 ALDH16A1 25348397 N/A physical interaction ComPPI
TLR1 DERA 25348397 N/A physical interaction ComPPI
TLR1 CNPY3 25348397 N/A physical interaction ComPPI
TLR1 TBC1D24 25348397 N/A physical interaction ComPPI
TLR1 TMEM214 25348397 N/A physical interaction ComPPI
TLR1 PLXNB2 25348397 N/A physical interaction ComPPI
TLR1 MAVS 25348397 N/A physical interaction ComPPI
TLR1 SIGLEC9 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
SIGLEC5 TLR1 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR1 TLR1 23155421 24234451 physical association fluorescence technology,tox-r dimerization assay IntAct
TLR1 FLNA 16482509 27898060 N/A N/A OmniPath
TLR1 HSPD1 16482509 27898060 N/A N/A OmniPath
TLR1 HSP90B1 11584270 27898060 N/A N/A OmniPath
TLR4 TLR1 11932926 27898060 N/A N/A OmniPath
TLR1 TLR10 15728506 27898060 N/A N/A OmniPath
TLR10 TLR1 15728506 27898060 N/A N/A OmniPath
MYD88 TLR1 19717524 22673208 27898060 N/A N/A OmniPath
TLR1 TLR2 12077222 16455995 16848791 20348427 22673208 27898060 N/A N/A OmniPath
TLR1 TRAP1 16482509 27898060 N/A N/A OmniPath
TIRAP TLR1 19717524 22673208 27898060 N/A N/A OmniPath
TLR1 TLR6 16455995 27898060 N/A N/A OmniPath
TLR1 DHX36 16482509 27898060 N/A N/A OmniPath
TLR1 ECHS1 16482509 27898060 N/A N/A OmniPath

Visualization










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