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GENE：LAPTM4B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAPTM4B
FullNmae lysosomal protein transmembrane 4 beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13646
EnsembleID ENSG00000104341
Uniprot Q86VI4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAPTM4B lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
LAPTM4B lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
LAPTM4B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LAPTM4B GO:0005515,GO:0005764,GO:0005765,GO:0005765,GO:0005768,GO:0005769,GO:0005886,GO:0007032,GO:0019900,GO:0031625,GO:0031902,GO:0032509,GO:0032585,GO:0032911,GO:0042995,GO:0097001,GO:0097213,GO:0097487,GO:1902936,GO:1905166,GO:1905671

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAPTM4B hsa:55353 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LAPTM4B E2F1 21310950 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 LAPTM4B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LAPTM4B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 LAPTM4B 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LAPTM4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 LAPTM4B 23469012 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000345DEB LAPTM4B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 LAPTM4B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000330617 LAPTM4B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004BC299 LAPTM4B 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C LAPTM4B 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 LAPTM4B 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B LAPTM4B 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 LAPTM4B 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002AAD6B LAPTM4B 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000015F70F LAPTM4B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 LAPTM4B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 LAPTM4B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 LAPTM4B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 LAPTM4B 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TFRC LAPTM4B 25348397 N/A physical interaction ComPPI
PIK3R1 LAPTM4B 25348397 N/A pull down ComPPI
FGFR2 LAPTM4B 24234451 25348397 25594178 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
PDGFRB LAPTM4B 24234451 25348397 25594178 physical association anti tag coimmunoprecipitation ComPPI,IntAct
HGS LAPTM4B 25348397 N/A physical interaction ComPPI
EXOC3 LAPTM4B 24234451 25348397 25594178 physical association anti tag coimmunoprecipitation ComPPI,IntAct
EXOC4 LAPTM4B 24234451 25348397 25594178 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
MET LAPTM4B 24234451 25348397 25594178 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
EGFR LAPTM4B 24234451 25348397 25594178 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
NEDD4 LAPTM4B 22096579 25348397 25588945 27898060 N/A physical interaction ComPPI,OmniPath
PIP5K1C LAPTM4B 25348397 N/A physical interaction ComPPI
GJA8 LAPTM4B 25348397 N/A two hybrid ComPPI
SNX5 LAPTM4B 25348397 N/A physical interaction ComPPI
TNFRSF10A LAPTM4B 25348397 N/A physical interaction ComPPI
TNFRSF10B LAPTM4B 25348397 N/A physical interaction ComPPI
IL20RA LAPTM4B 25348397 N/A physical interaction ComPPI
LYPD3 LAPTM4B 25348397 N/A physical interaction ComPPI
EXOC7 LAPTM4B 24234451 25348397 25594178 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
DLK1 LAPTM4B 25348397 N/A physical interaction ComPPI
ABCB1 LAPTM4B 20711237 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct,OmniPath
LAPTM4B NAALADL2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LAPTM4B TMEM231 25348397 N/A physical interaction ComPPI
LAPTM4B RETREG1 25348397 N/A physical interaction ComPPI
LAPTM4B SLCO6A1 25348397 N/A physical interaction ComPPI
LAPTM4B ENTPD7 25348397 N/A physical interaction ComPPI
LAPTM4B PCDHAC2 25348397 N/A physical interaction ComPPI
LAPTM4B EMP1 25348397 N/A two hybrid ComPPI
LAPTM4B GPX8 25348397 N/A two hybrid ComPPI
LAPTM4B ODF4 25348397 N/A two hybrid ComPPI
LAPTM4B ISLR2 25348397 N/A two hybrid ComPPI
MTIF3 LAPTM4B 25348397 N/A two hybrid ComPPI
BDKRB1 LAPTM4B 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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