GENE：CHMP3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP3 |
| FullNmae | charged multivesicular body protein 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29865 |
| EnsembleID | ENSG00000115561 |
| Uniprot | Q9Y3E7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP3 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP3 | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP3 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP3 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP3 | GO:0000421,GO:0000776,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005546,GO:0005643,GO:0005765,GO:0005769,GO:0005770,GO:0005771,GO:0005828,GO:0005829,GO:0005886,GO:0006914,GO:0006915,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0016236,GO:0019076,GO:0019076,GO:0030496,GO:0031210,GO:0031410,GO:0031468,GO:0032467,GO:0032509,GO:0032585,GO:0036258,GO:0036258,GO:0039702,GO:0039702,GO:0039702,GO:0043162,GO:0044790,GO:0045324,GO:0046761,GO:0046761,GO:0051036,GO:0051258,GO:0051469,GO:0061763,GO:0061763,GO:0061952,GO:0070062,GO:0071985,GO:0071985,GO:0090148,GO:0097352,GO:0097352,GO:0140678,GO:1901673,GO:1902774,GO:1904930,GO:1990381,GO:2000641 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP3 | hsa:51652 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP3 | hsa:51652 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CHMP3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | CHMP3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | CHMP3 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CHMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | CHMP3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000324096 | CHMP3 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000105D19 | CHMP3 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CC005 | CHMP3 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BD73 | CHMP3 | 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000472A9B | CHMP3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | CHMP3 | 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D793 | CHMP3 | 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C7B2B | CHMP3 | 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | CHMP3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | CHMP3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | CHMP3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | CHMP3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003003B4 | CHMP3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FAA8C | CHMP3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000331800 | CHMP3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0920 | CHMP3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003E1A9 | CHMP3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | CHMP3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | CHMP3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | CHMP3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DAXX | CHMP3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2A | CHMP3 | 14525934 16730941 23051622 24234451 25348397 | protein cleavage,physical association | two hybrid,transmission electron microscopy,pull down,surface plasmon resonance,physical interaction,enzymatic footprinting,two hybrid | ComPPI,HPRD,IntAct |
| SMAD1 | CHMP3 | 14525934 15231748 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| VAV2 | CHMP3 | 18654987 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SMAD5 | CHMP3 | 14525934 15231748 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP3 | IGFBP7 | 11549700 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| CHMP3 | STAMBP | 14525934 16431367 16730941 16760479 17146056 17159328 17261583 17711858 18395747 19615732 21827950 24234451 25348397 25416956 26186194 27898060 29997244 | colocalization,physical association | anti tag coimmunoprecipitation,beta lactamase complementation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,confocal microscopy,surface plasmon resonance array,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct,OmniPath |
| CHMP3 | CHMP2B | 14525934 16730941 23051622 24234451 25348397 | physical association | two hybrid,surface plasmon resonance,physical interaction,surface plasmon resonance array,two hybrid | ComPPI,HPRD,IntAct |
| CHMP3 | RAB11A | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP3 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| CHMP3 | APP | 25348397 | N/A | physical interaction | ComPPI |
| CHMP3 | MEPCE | 25348397 | N/A | physical interaction | ComPPI |
| CHMP3 | STEEP1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP3 | TFG | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP3 | CHMP5 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP3 | USP8 | 19302785 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| CHMP3 | FOS | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |