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GENE：DKK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DKK2
FullNmae dickkopf WNT signaling pathway inhibitor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2892
EnsembleID ENSG00000155011
Uniprot Q9UBU2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DKK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DKK2 GO:0005515,GO:0005615,GO:0005615,GO:0016055,GO:0039706,GO:0048019,GO:0090090,GO:0090090,GO:0090090,GO:0090263,GO:0090263

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DKK2 hsa:27123 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
DKK2 hsa:27123 path:hsa05010 Alzheimer disease - Homo sapiens (human)
DKK2 hsa:27123 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 DKK2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 DKK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 DKK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 DKK2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DKK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 DKK2 20018759 rna interference,inhibition array technology,experimental interaction detection miRSponge
URS0000170CF4 DKK2 20018759 25416803 27501171 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 DKK2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000153377 DKK2 23587485 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000239117 DKK2 23591200 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001B341F DKK2 25416803 26656471 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
LRP6 DKK2 25361965 interaction type N/A PTMCode2
DKK2 LRP6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LRP6 DKK2 11357136 11742004 14525934 21944579 24234451 25348397 N/A experimental interaction detection,physical interaction,in vivo,bio-layer interferometry ComPPI,HPRD,IntAct
DKK2 KRTAP10-6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DKK2 KREMEN2 12527209 27898060 N/A N/A OmniPath

Visualization










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