GENE：DLL4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DLL4 |
| FullNmae | delta like canonical Notch ligand 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2910 |
| EnsembleID | ENSG00000128917 |
| Uniprot | Q9NR61 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DLL4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DLL4 | GO:0000122,GO:0001525,GO:0001569,GO:0001974,GO:0003180,GO:0003208,GO:0003209,GO:0003222,GO:0003344,GO:0005112,GO:0005112,GO:0005509,GO:0005515,GO:0005886,GO:0005886,GO:0007165,GO:0007219,GO:0007219,GO:0007601,GO:0008015,GO:0008285,GO:0010596,GO:0010628,GO:0010629,GO:0030217,GO:0035912,GO:0035924,GO:0044344,GO:0045746,GO:0045746,GO:0045747,GO:0048018,GO:0050767,GO:0060579,GO:0061074,GO:0061314,GO:0072554,GO:0090051,GO:0090051,GO:1903588,GO:2000179 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DLL4 | hsa:54567 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| DLL4 | hsa:54567 | path:hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| DLL4 | hsa:54567 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| DLL4 | hsa:54567 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| DLL4 | hsa:54567 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| DLL4 | hsa:54567 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DLL4 | DLL4 | 10837024 11739188 16140393 26467481 | bind,up-regulates activity | N/A | Signor |
| DLL4 | NOTCH4 | 10837027 12814948 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| DLL4 | NOTCH1 | 10837024 11739188 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| SYNJ2BP | DLL4 | 24025447 | interaction type,stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRDM14 | DLL4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTCF | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | DLL4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SIRT1 | DLL4 | 20631301 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002152A8 | DLL4 | 23086751 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000075E538 | DLL4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005D4F5 | DLL4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | DLL4 | 25416803 26872979 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001F0C23 | DLL4 | 25416803 27252357 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00001C3AC1 | DLL4 | 25416803 26500043 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DLL4 | NOTCH4 | 12814948 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| DLL4 | NOTCH1 | 10837024 11739188 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SYNJ2BP | DLL4 | 24025447 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,confocal microscopy,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| DLL4 | NOTCH1 | 10837024 11739188 16140393 27898060 | stimulant | N/A | OmniPath |
| MIB1 | DLL4 | 16000382 16140393 23162128 27898060 | stimulant | N/A | OmniPath |
| DLL4 | NOTCH2 | 22842086 27898060 | stimulant | N/A | OmniPath |
| DLL4 | NOTCH3 | 18182388 27898060 | stimulant | N/A | OmniPath |
| DLL4 | NOTCH4 | 10837027 12814948 1281495 16219802 27898060 | stimulant | N/A | OmniPath |