Gene Information gene info

  1. Home

GENE：DVL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DVL1
FullNmae dishevelled segment polarity protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3084
EnsembleID ENSG00000107404
Uniprot O14640

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DVL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DVL1 GO:0001505,GO:0001934,GO:0001947,GO:0003151,GO:0005109,GO:0005109,GO:0005109,GO:0005515,GO:0005829,GO:0005829,GO:0005874,GO:0006355,GO:0006469,GO:0007269,GO:0007411,GO:0007528,GO:0008013,GO:0010976,GO:0014069,GO:0016328,GO:0019899,GO:0019901,GO:0021915,GO:0022007,GO:0030136,GO:0030426,GO:0031122,GO:0031267,GO:0031410,GO:0031410,GO:0032091,GO:0032436,GO:0032880,GO:0034504,GO:0035176,GO:0035372,GO:0035556,GO:0035567,GO:0042802,GO:0043005,GO:0043025,GO:0043113,GO:0043197,GO:0045202,GO:0045944,GO:0048668,GO:0048675,GO:0048813,GO:0050808,GO:0050821,GO:0060070,GO:0060070,GO:0060070,GO:0060070,GO:0060071,GO:0060071,GO:0060134,GO:0060997,GO:0071340,GO:0090103,GO:0090179,GO:0098685,GO:0098793,GO:0098978,GO:0098992,GO:0099054,GO:0099175,GO:0150012,GO:1905386,GO:1990909,GO:2000300,GO:2000463

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DVL1 hsa:1855 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
DVL1 hsa:1855 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
DVL1 hsa:1855 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
DVL1 hsa:1855 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
DVL1 hsa:1855 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
DVL1 hsa:1855 path:hsa04916 Melanogenesis - Homo sapiens (human)
DVL1 hsa:1855 path:hsa04934 Cushing syndrome - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05010 Alzheimer disease - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05200 Pathways in cancer - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05224 Breast cancer - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
DVL1 hsa:1855 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AXIN1 DVL1 10428961 16288291 16940750 19751508 22270359 26192618 8666229 interaction type N/A ACSN
DVL1 DVL1 15735151 17569865 18347071 19365405 23151663 26467481 interaction type,bind,up-regulates,up-regulates activity N/A Signor
DVL1 LRRK2 20006983 23331499 stimulation N/A SignaLink,SignaLink
DVL1 PI4K2B 19561074 23331499 stimulation N/A SignaLink,SignaLink
DIXDC1 DVL1 21189423 interaction type,stimulation N/A SignaLink
ARRB1 DVL1 11742073 23331499 stimulation N/A SignaLink
CSNK1D DVL1 11818547 23331499 stimulation N/A SignaLink
RYK DVL1 15454084 23331499 stimulation N/A SignaLink
ANAPC2 DVL1 20006983 23331499 inhibition N/A SignaLink
DVL1 CTNNB1 10806215 20006983 23331499 stimulation N/A SignaLink
DVL1 JUN 20006983 23331499 stimulation N/A SignaLink
CSNK1E DVL1 20006983 23331499 stimulation N/A SignaLink
DVL1 DAAM1 20006983 23331499 stimulation N/A SignaLink
INVS DVL1 20006983 23331499 stimulation N/A SignaLink
SMAD1 DVL1 16621789 23331499 stimulation N/A SignaLink
DVL1 SMAD3 12650946 23331499 stimulation N/A SignaLink
DVL1 ROCK1 15121866 23331499 stimulation N/A SignaLink
DVL1 RAC1 12533515 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DVL1 PPM1A 20005715 interaction type N/A PSP
DVL1 CSNK1D 20005715 interaction type N/A PSP
DVL1 CSNK1E 20005715 interaction type N/A PSP
DVL1 RAC1 20005715 interaction type N/A PSP,SignaLink
DVL1 CSNK2A1 20005715 interaction type N/A PSP
DVL1 CSNK1D 11818547 11818547 18988627 20005715 20005715 21071413 N/A N/A SignaLink
DVL1 CSNK1E 11487578 11818547 11818547 18988627 20005715 20005715 21071413 N/A N/A SignaLink
DVL1 CSNK2A1 10806215 18988627 20005715 20005715 N/A N/A SignaLink
DVL1 PPM1A 10644691 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 DVL1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA2 DVL1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DVL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE DVL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 DVL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 DVL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000246356 DVL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 DVL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003FD55 DVL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 DVL1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EPS8 DVL1 25361965 interaction type N/A PTMCode2
DVL1 EPS8 25361965 interaction type N/A PTMCode2
NKD2 DVL1 25361965 interaction type N/A PTMCode2
DVL1 NKD2 25361965 interaction type N/A PTMCode2
LRP5 DVL1 25361965 interaction type N/A PTMCode2
DVL1 LRP5 25361965 interaction type N/A PTMCode2
CSNK2A1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 CSNK2A1 25361965 interaction type N/A PTMCode2
VANGL2 DVL1 25361965 interaction type N/A PTMCode2
DVL1 VANGL2 25361965 interaction type N/A PTMCode2
INVS DVL1 25361965 interaction type N/A PTMCode2
DVL1 INVS 25361965 interaction type N/A PTMCode2
CSNK1E DVL1 25361965 interaction type N/A PTMCode2
DVL1 CSNK1E 25361965 interaction type N/A PTMCode2
VANGL1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 VANGL1 25361965 interaction type N/A PTMCode2
DAAM1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 DAAM1 25361965 interaction type N/A PTMCode2
AXIN1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 AXIN1 25361965 interaction type N/A PTMCode2
CSNK1D DVL1 25361965 interaction type N/A PTMCode2
DVL1 CSNK1D 25361965 interaction type N/A PTMCode2
RAC1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 RAC1 25361965 interaction type N/A PTMCode2
LRP6 DVL1 25361965 interaction type N/A PTMCode2
DVL1 LRP6 25361965 interaction type N/A PTMCode2
DVL1 CCDC88C 25361965 interaction type N/A PTMCode2
CCDC88C DVL1 25361965 interaction type N/A PTMCode2
DVL1 BRD7 25361965 interaction type N/A PTMCode2
BRD7 DVL1 25361965 interaction type N/A PTMCode2
DVL1 HECW1 25361965 interaction type N/A PTMCode2
HECW1 DVL1 25361965 interaction type N/A PTMCode2
NKD1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 NKD1 25361965 interaction type N/A PTMCode2
FRAT1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 FRAT1 25361965 interaction type N/A PTMCode2
CTNNB1 DVL1 25361965 interaction type N/A PTMCode2
DVL1 CTNNB1 25361965 interaction type N/A PTMCode2
ARHGEF19 DVL1 25361965 interaction type N/A PTMCode2
DVL1 ARHGEF19 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 DVL1 25348397 N/A physical interaction ComPPI
CEP19 DVL1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SMAD4 DVL1 12650946 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RAC1 DVL1 12533515 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CSNK1D DVL1 11818547 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CETN2 DVL1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SMAD1 DVL1 25348397 N/A physical interaction ComPPI
DAB2 DVL1 25348397 N/A physical interaction ComPPI
SMAD7 DVL1 12650946 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
FBXW7 DVL1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RB1 DVL1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD2 DVL1 12650946 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SMAD3 DVL1 12650946 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
FLNC DVL1 25348397 N/A physical interaction ComPPI
PSMA3 DVL1 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
DAAM1 DVL1 11779461 14525934 22705156 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RASSF9 DVL1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SCYL2 DVL1 19643732 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PPM1A DVL1 10644691 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
APC DVL1 11425858 20224554 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
BTRC DVL1 25348397 N/A physical interaction ComPPI
AXIN1 DVL1 10330403 12556519 14525934 25348397 9482734 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
WWP2 DVL1 25348397 N/A physical interaction ComPPI
EPS8 DVL1 10581192 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
CSNK1E DVL1 11425858 11487578 11818547 14525934 24234451 25348397 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
BUB1 DVL1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CSNK2A1 DVL1 10806215 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
DCTN1 DVL1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CEP135 DVL1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SDC4 DVL1 25348397 N/A physical interaction ComPPI
XPO1 DVL1 25348397 N/A physical interaction ComPPI
ARRB1 DVL1 11742073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HUWE1 DVL1 25348397 N/A physical interaction ComPPI
USP13 DVL1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DVL1 VANGL2 12490194 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DVL1 FRAT1 10428961 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DVL1 HECW1 14525934 14684739 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
DVL1 BRD7 25348397 N/A two hybrid,in vitro,in vivo ComPPI
DVL1 CXXC4 25348397 N/A two hybrid,in vitro,in vivo ComPPI
DVL1 VANGL1 14525934 15456783 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
DVL1 CTNNB1 10806215 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
DVL1 DVL3 10330181 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
DVL1 DYNLT1 10644691 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DVL1 HDHD2 14525934 16169070 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DVL1 CCDC88C 14525934 14750955 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
DVL1 ATN1 25348397 N/A physical interaction ComPPI
DVL1 DVL1P1 25348397 N/A physical interaction ComPPI
DVL1 SIRT1 20439735 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DVL1 CYLD 25348397 N/A physical interaction ComPPI
DVL1 NKD2 20177058 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DVL1 ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DVL1 NEDD4 25348397 N/A physical interaction ComPPI
DVL1 ITCH 25348397 N/A physical interaction ComPPI
DVL1 LRRK2 25348397 N/A physical interaction ComPPI
DVL1 SIPA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DVL1 WWOX 25348397 N/A physical interaction ComPPI
DVL1 DVL2 20224554 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DVL1 NUMA1 25348397 N/A physical interaction ComPPI
DVL1 TRIM69 25348397 N/A physical interaction ComPPI
DVL1 WWTR1 20412773 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
DVL1 RASSF10 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DVL1 AHI1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 SSX2IP 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 CCP110 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 KIAA0753 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 CEP44 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 CEP83 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DVL1 ARHGEF19 18256687 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
DVL1 PTK2 20224554 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DVL1 TFDP1 22773187 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
DVL1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DVL1 MSH2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DVL1 TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT DVL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DVL1 DVL1 10330181 14525934 24234451 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down HPRD,IntAct
WWTR1 DVL1 20412773 22153608 27898060 inhibition N/A OmniPath
DVL1 CTNNB1 10806215 15735151 25241761 27898060 inhibition,stimulant N/A OmniPath
ARRB1 DVL1 11742073 27898060 stimulant N/A OmniPath
YAP1 DVL1 23178811 27898060 inhibition N/A OmniPath
DVL1 ROCK1 15121866 27898060 stimulant N/A OmniPath
CSNK1E DVL1 11425858 11487578 11818547 14966280 16965538 20006983 21285348 27898060 stimulant N/A OmniPath
SMAD1 DVL1 16621789 27898060 stimulant N/A OmniPath
DVL1 LRP6 17569865 27898060 stimulant N/A OmniPath
DVL1 RAC1 12533515 15608632 17363564 19365405 27898060 stimulant N/A OmniPath
CSNK1D DVL1 11818547 27898060 stimulant N/A OmniPath
DVL1 F2R 11433294 27898060 stimulant N/A OmniPath
DVL1 APC 10330181 20224554 27898060 inhibition N/A OmniPath
WNT5A DVL1 21078818 27898060 stimulant N/A OmniPath
DVL1 AXIN1 10330181 10330403 10428961 10862053 11027605 11113207 11278246 12556519 18339531 18632848 27898060 9482734 inhibition N/A OmniPath
DVL1 GSK3B 20837657 27898060 inhibition N/A OmniPath
DVL1 JUN 18347071 27898060 stimulant N/A OmniPath
DVL1 SMAD3 12650946 27898060 stimulant N/A OmniPath
FZD3 DVL1 22944199 27898060 stimulant N/A OmniPath
DVL1 DAAM1 11779461 19365405 22705156 27898060 stimulant N/A OmniPath
RYK DVL1 15454084 27898060 stimulant N/A OmniPath
WNT3A DVL1 18772438 27898060 stimulant N/A OmniPath
FZD1 DVL1 22944199 27898060 stimulant N/A OmniPath
FZD6 DVL1 22944199 27898060 stimulant N/A OmniPath
CSNK1G1 DVL1 10409711 10806215 27898060 9214626 stimulant N/A OmniPath
SDC4 DVL1 23151663 27898060 stimulant N/A OmniPath
INVS DVL1 15852005 27898060 inhibition N/A OmniPath
ANAPC2 DVL1 19805045 27898060 inhibition N/A OmniPath

Visualization










  Return