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GENE：DYRK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DYRK2
FullNmae dual specificity tyrosine phosphorylation regulated kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3093
EnsembleID ENSG00000127334
Uniprot Q92630

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DYRK2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYRK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYRK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYRK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DYRK2 GO:0000151,GO:0000287,GO:0004674,GO:0004674,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0006974,GO:0007224,GO:0018105,GO:0018107,GO:0030145,GO:0042771,GO:0045725,GO:0070885,GO:0106310,GO:1901796,GO:1990904

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CARHSP1 DYRK2 15910284 23180781 phosphorylation reaction in-gel kinase assay,protein kinase assay InnateDB
DYRK2 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP DYRK2 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR DYRK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DYRK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DYRK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 DYRK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DYRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 DYRK2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 DYRK2 20371350 21572407 23622248 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip,clash TarBase
URS00005651EE DYRK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 DYRK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 DYRK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 DYRK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000272039 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000013E79D DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 DYRK2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 DYRK2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000003BF62 DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000055128B DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BD6DC DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000424278 DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009EA8F DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E02F2 DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000156390 DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B DYRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000FC8EB DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 DYRK2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 DYRK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 DYRK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D DYRK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000017EE98 DYRK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 DYRK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F DYRK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C DYRK2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 DYRK2 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K10 DYRK2 22135298 phosphorylation N/A PhosphoSite
DYRK2 EIF4EBP1 22135298 phosphorylation N/A PhosphoSite
DYRK2 SIAH2 22135298 phosphorylation N/A PhosphoSite
DYRK2 H3-3A 22135298 phosphorylation N/A PhosphoSite
DYRK2 CARHSP1 22135298 phosphorylation N/A PhosphoSite
DYRK2 KATNA1 22135298 phosphorylation N/A PhosphoSite
DYRK2 TP53 22135298 phosphorylation N/A PhosphoSite
DYRK2 DPYSL3 22135298 phosphorylation N/A PhosphoSite
DYRK2 DPYSL2 22135298 phosphorylation N/A PhosphoSite
DYRK2 PSMC4 22135298 phosphorylation N/A PhosphoSite
DYRK2 TBK1 22135298 phosphorylation N/A PhosphoSite
DYRK2 CRMP1 22135298 phosphorylation N/A PhosphoSite
ATM DYRK2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSPA8 DYRK2 25348397 N/A physical interaction ComPPI
LZTS2 DYRK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NPM1 DYRK2 25348397 N/A physical interaction ComPPI
ZBTB9 DYRK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2D1 DYRK2 25348397 N/A physical interaction ComPPI
HSP90AB1 DYRK2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
MOAP1 DYRK2 25348397 N/A physical interaction ComPPI
KXD1 DYRK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SIAH2 DYRK2 25348397 N/A physical interaction ComPPI
TTN DYRK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DAP3 DYRK2 25348397 N/A physical interaction ComPPI
HSP90AA1 DYRK2 25348397 N/A physical interaction ComPPI
NR1I2 DYRK2 25348397 N/A physical interaction ComPPI
HSPA5 DYRK2 25348397 N/A physical interaction ComPPI
HSPA1A DYRK2 25348397 N/A physical interaction ComPPI
HSPA1B DYRK2 25348397 N/A physical interaction ComPPI
RPA1 DYRK2 25348397 N/A physical interaction ComPPI
HNRNPU DYRK2 25348397 N/A physical interaction ComPPI
AKAP12 DYRK2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
UBR5 DYRK2 25348397 N/A physical interaction ComPPI
TERT DYRK2 25348397 N/A physical interaction ComPPI
PDHB DYRK2 25348397 N/A physical interaction ComPPI
KIF3B DYRK2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAD54B DYRK2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATM DYRK2 25348397 N/A physical interaction ComPPI
H2BC21 DYRK2 14525934 25348397 9748265 N/A experimental interaction detection,in vitro ComPPI,HPRD
RNF8 DYRK2 25348397 N/A physical interaction ComPPI
SP100 DYRK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RPL4 DYRK2 25348397 N/A physical interaction ComPPI
RPLP0 DYRK2 25348397 N/A physical interaction ComPPI
MDM2 DYRK2 25348397 N/A physical interaction ComPPI
RPL7A DYRK2 25348397 N/A physical interaction ComPPI
H3-4 DYRK2 14525934 25348397 9748265 N/A experimental interaction detection,in vitro ComPPI,HPRD
STK4 DYRK2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPL7 DYRK2 25348397 N/A physical interaction ComPPI
RTN1 DYRK2 25348397 N/A physical interaction ComPPI
IKZF1 DYRK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PCMT1 DYRK2 25348397 N/A physical interaction ComPPI
TBK1 DYRK2 25348397 N/A physical interaction ComPPI
RB1CC1 DYRK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DDB1 DYRK2 25348397 N/A physical interaction ComPPI
DYRK2 FSBP 25348397 N/A physical interaction ComPPI
DYRK2 DCAF7 25348397 N/A physical interaction ComPPI
DYRK2 DCAF1 25348397 N/A physical interaction ComPPI
DYRK2 DLST 25348397 N/A physical interaction ComPPI
DYRK2 XPNPEP3 25348397 N/A physical interaction ComPPI
DYRK2 RPS2 25348397 N/A physical interaction ComPPI
DYRK2 SSBP2 25348397 N/A physical interaction ComPPI
DYRK2 TUBA1C 25348397 N/A physical interaction ComPPI
DYRK2 RPLP0P6 25348397 N/A physical interaction ComPPI
DYRK2 SLC25A3 25348397 N/A physical interaction ComPPI
DYRK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
DYRK2 TUBA3C 25348397 N/A physical interaction ComPPI
DYRK2 RBMXL2 25348397 N/A physical interaction ComPPI
DYRK2 HSPA6 25348397 N/A physical interaction ComPPI
DYRK2 RPL18 25348397 N/A physical interaction ComPPI
DYRK2 KATNA1 25348397 N/A physical interaction ComPPI
DYRK2 APP 25348397 N/A physical interaction ComPPI
DYRK2 DYRK4 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,bimolecular fluorescence complementation ComPPI,IntAct
DYRK2 WDR62 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DYRK2 DCAF5 25348397 N/A physical interaction ComPPI
DYRK2 SAV1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DYRK2 KIF3C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DYRK2 CEP78 25348397 N/A physical interaction ComPPI
DYRK2 CCP110 25348397 N/A physical interaction ComPPI
DYRK2 ACCS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DYRK2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SGG DYRK2 25348397 N/A anti tag coimmunoprecipitation ComPPI
DYRK2 N 24234451 25294943 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATM DYRK2 19965871 27898060 stimulant N/A OmniPath
DYRK2 TP53 17349958 17386256 19965871 27898060 stimulant N/A OmniPath
DYRK2 TBK1 26407194 27898060 N/A N/A OmniPath
DYRK2 STAT3 12763138 15465816 16219639 17875724 18234692 18599021 18669648 18691976 19413330 27898060 7701321 N/A N/A OmniPath
DYRK2 SIAH2 19043406 22878263 23000554 23044042 27898060 stimulant N/A OmniPath
DYRK2 JUN 22307329 27898060 inhibition N/A OmniPath
DYRK2 SDC2 27898060 9244383 N/A N/A OmniPath
DYRK2 CARHSP1 15910284 21177848 27898060 N/A N/A OmniPath
DYRK2 RGS14 12534294 27898060 N/A N/A OmniPath
DYRK2 DPYSL3 16611631 17081983 27898060 stimulant N/A OmniPath
DYRK2 KATNA1 19287380 27898060 N/A N/A OmniPath

Visualization










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