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GENE：E2F6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol E2F6
FullNmae E2F transcription factor 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3120
EnsembleID ENSG00000169016
Uniprot O75461

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
E2F6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
E2F6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
E2F6 GO:0000083,GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006357,GO:0046983,GO:0071339,GO:0090575,GO:0090575

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
E2F6 hsa:1876 path:hsa03083 Polycomb repressive complex - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F6 EPC1 15536069 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F6 EZH2 15536069 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F6 SIN3B 15536069 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 E2F6 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 E2F6 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 E2F6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 E2F6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 E2F6 16107498 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 E2F6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 E2F6 17096023 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E3523 E2F6 18381414 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000016C318 E2F6 20445018 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000367985 E2F6 18381414 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001799A3 E2F6 20445018 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000367985 E2F6 18381414 18927107 25416803 26125439 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00001E3523 E2F6 18381414 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 E2F6 17699775 20371350 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00001799A3 E2F6 20445018 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000016C318 E2F6 20445018 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000AA464 E2F6 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 E2F6 19088304 20371350 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00001C0099 E2F6 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 E2F6 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC E2F6 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002ED720 E2F6 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000017DBB8 E2F6 20371350 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003D8730 E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 E2F6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000026A1D E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015CE89 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003804D8 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005D4F5 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D1FC E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004505E4 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006097A6 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AB0E E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005D35D9 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023133F E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000482389 E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075B13F E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000012930C E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004407DC E2F6 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 E2F6 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CBX8 E2F6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCF19 E2F6 25348397 N/A physical interaction ComPPI
PSMC3 E2F6 25348397 N/A physical interaction ComPPI
E2F6 KRTAP10-7 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
E2F6 TFDP1 16189514 24234451 25348397 25416956 26871637 27705803 association,physical association physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
E2F6 E2F1 25348397 N/A in vitro ComPPI
E2F6 EZH2 25348397 N/A physical interaction,in vivo ComPPI
E2F6 RING1 24234451 25348397 27705803 association physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,IntAct
E2F6 TFDP2 16189514 21516116 24234451 25348397 25416956 27705803 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
E2F6 PCGF6 24234451 25348397 27705803 association physical interaction,in vitro,tandem affinity purification ComPPI,IntAct
E2F6 RYBP 11171983 24234451 25348397 27705803 association,physical association two hybrid,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,IntAct
E2F6 EPC1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
E2F6 ZMYND11 25348397 N/A physical interaction,in vitro,in vivo ComPPI
E2F6 EZH1 25348397 N/A physical interaction,in vivo ComPPI
E2F6 BMI1 11171983 24234451 25348397 physical association coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
E2F6 CBX3 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 ZMYND8 25348397 N/A physical interaction ComPPI
E2F6 KDM5C 17468742 24234451 25348397 26496610 association anti tag coimmunoprecipitation,cosedimentation through density gradient,physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 KMT2A 25348397 N/A physical interaction ComPPI
E2F6 KMT2D 25348397 N/A physical interaction ComPPI
E2F6 EED 25348397 N/A physical interaction ComPPI
E2F6 L3MBTL2 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 SMARCAD1 25348397 N/A physical interaction ComPPI
E2F6 RNF2 17468742 24234451 25348397 27705803 association cosedimentation through density gradient,physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 YAF2 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 APP 25348397 N/A physical interaction ComPPI
E2F6 LYN 25348397 N/A physical interaction ComPPI
E2F6 ARAF 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
E2F6 MGA 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 COMMD6 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 COMMD4 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 WDR5 24234451 25348397 27705803 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 CARD8 25348397 N/A physical interaction ComPPI
E2F6 MIER2 25348397 N/A physical interaction ComPPI
E2F6 PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
E2F6 HDAC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F6 MAX 24234451 25348397 25609649 27705803 association,physical association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 ESR1 25348397 N/A physical interaction ComPPI
E2F6 DNMT3L 25348397 N/A physical interaction ComPPI
E2F6 COMMD8 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 COMMD1 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
E2F6 ASB6 25348397 N/A physical interaction ComPPI
E2F6 MXD1 25348397 N/A physical interaction ComPPI
E2F6 L3MBTL3 17517653 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F6 REEP5 12004135 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
E2F6 PCGF2 11171983 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
E2F6 CBX1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 CST4 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 CST2 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 SMR3B 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 HSPB1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 LGALS7 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 GLUD1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 ARG1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 S100A7 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 GSTP1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 TUBA1C 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 HDAC2 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 SPRR2E 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 ZMYM4 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 APOD 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 TGM3 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 SPRR1B 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 AMY1C 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 POF1B 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 S100A11 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 RPL39 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
E2F6 REST 17468742 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
E2F6 UXT 12909625 27898060 inhibition N/A OmniPath
E2F6 RBBP8 12909625 18319725 27898060 inhibition N/A OmniPath
E2F6 E2F1 12909625 18562691 27898060 9689056 inhibition N/A OmniPath
E2F6 CBX5 12909625 18319725 27898060 inhibition N/A OmniPath
E2F6 BRCA1 12909625 18319725 27898060 inhibition N/A OmniPath

Visualization










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