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GENE：GHR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GHR
FullNmae growth hormone receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4263
EnsembleID ENSG00000112964
Uniprot P10912

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GHR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GHR GO:0004903,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006897,GO:0007259,GO:0008289,GO:0009629,GO:0009755,GO:0009897,GO:0009986,GO:0016020,GO:0017046,GO:0017046,GO:0019221,GO:0019530,GO:0019838,GO:0019901,GO:0019903,GO:0019955,GO:0032094,GO:0032107,GO:0032869,GO:0032870,GO:0036464,GO:0040014,GO:0040018,GO:0042169,GO:0042445,GO:0042531,GO:0042802,GO:0042803,GO:0043025,GO:0043235,GO:0043406,GO:0045597,GO:0046427,GO:0048009,GO:0050731,GO:0050731,GO:0051384,GO:0060351,GO:0060396,GO:0060396,GO:0070064,GO:0070195,GO:0070195,GO:0070555

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GHR hsa:2690 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
GHR hsa:2690 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
GHR hsa:2690 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
GHR hsa:2690 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
GHR hsa:2690 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GHR SOCS2 12135564 23180781 physical association gst pull down,competition binding InnateDB
GHR CISH 10585430 23180781 24243840 29145629 physical association pull down,inferred by curator InnateDB,Reactome
PLCG1 GHR 17474147 23180781 physical association peptide array InnateDB
GH1 GHR 1549776 1935820 19927328 21889455 23180781 23331499 24243840 2825030 29145629 3349036 7691587 9030599 stimulation,physical association x-ray crystallography,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
IGF1R GHR 23180781 25211187 physical association anti tag coimmunoprecipitation InnateDB
GHR IGF1R 23180781 25211187 physical association anti tag coimmunoprecipitation InnateDB
GHR GHR 1948064 24243840 29145629 9058373 physical association inferred by curator Reactome
GH2 GHR 1549776 19927328 24243840 2825030 29145629 3349036 7691587 9030599 physical association inferred by curator Reactome
GHR STAT1 24243840 29145629 physical association inferred by curator Reactome
GHR STAT3 24243840 29145629 physical association inferred by curator Reactome
GHR PTPN6 24243840 29145629 physical association inferred by curator Reactome
GHR PTPN1 12907755 24243840 29145629 physical association inferred by curator Reactome
SOCS2 GHR 24243840 29145629 physical association inferred by curator Reactome
LYN GHR 24243840 29145629 physical association inferred by curator Reactome
GHR STAT5B 24243840 29145629 physical association inferred by curator Reactome
GHR STAT5A 10582086 23331499 24243840 29145629 interaction type,physical association inferred by curator Reactome,SignaLink,SignaLink
GHR ADAM17 24243840 29145629 cleavage reaction inferred by curator Reactome
GHR JAK2 10502458 18988627 23331499 7540178 8063815 9211920 stimulation N/A SignaLink,SignaLink
GHR TYK2 10502458 23331499 stimulation N/A SignaLink
GHR JAK1 10502458 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR GHR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 GHR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GHR 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GHR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
POU1F1 GHR 7529501 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SGTA GHR 25361965 interaction type N/A PTMCode2
GHR SGTA 25361965 interaction type N/A PTMCode2
GHR STAT3 25361965 interaction type N/A PTMCode2
STAT3 GHR 25361965 interaction type N/A PTMCode2
GHR TYK2 25361965 interaction type N/A PTMCode2
TYK2 GHR 25361965 interaction type N/A PTMCode2
GHR PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R1 GHR 25361965 interaction type N/A PTMCode2
GHR STAT5A 25361965 interaction type N/A PTMCode2
STAT5A GHR 25361965 interaction type N/A PTMCode2
GHR DUSP7 25361965 interaction type N/A PTMCode2
DUSP7 GHR 25361965 interaction type N/A PTMCode2
GHR PTPN9 25361965 interaction type N/A PTMCode2
PTPN9 GHR 25361965 interaction type N/A PTMCode2
GHR IRS1 25361965 interaction type N/A PTMCode2
IRS1 GHR 25361965 interaction type N/A PTMCode2
GHR CSH1 25361965 interaction type N/A PTMCode2
CSH1 GHR 25361965 interaction type N/A PTMCode2
GHR SOCS3 25361965 interaction type N/A PTMCode2
SOCS3 GHR 25361965 interaction type N/A PTMCode2
GHR GRB2 25361965 interaction type N/A PTMCode2
GRB2 GHR 25361965 interaction type N/A PTMCode2
GHR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 GHR 25361965 interaction type N/A PTMCode2
GHR JAK1 25361965 interaction type N/A PTMCode2
JAK1 GHR 25361965 interaction type N/A PTMCode2
GHR NCOA6 25361965 interaction type N/A PTMCode2
NCOA6 GHR 25361965 interaction type N/A PTMCode2
GHR JAK2 25361965 interaction type N/A PTMCode2
JAK2 GHR 25361965 interaction type N/A PTMCode2
GHR GRB10 25361965 interaction type N/A PTMCode2
GRB10 GHR 25361965 interaction type N/A PTMCode2
GHR PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 GHR 25361965 interaction type N/A PTMCode2
GHR JAK3 25361965 interaction type N/A PTMCode2
JAK3 GHR 25361965 interaction type N/A PTMCode2
GHR SHC1 25361965 interaction type N/A PTMCode2
SHC1 GHR 25361965 interaction type N/A PTMCode2
GHR CISH 25361965 interaction type N/A PTMCode2
CISH GHR 25361965 interaction type N/A PTMCode2
GHR GHR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 GHR 25348397 N/A physical interaction ComPPI
CUL5 GHR 25348397 N/A physical interaction ComPPI
SOCS3 GHR 10585430 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SGTA GHR 12735788 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PTPRH GHR 12907755 24234451 25348397 dephosphorylation reaction,physical association array technology,far western blotting,physical interaction,phosphatase assay ComPPI,IntAct
TYK2 GHR 10502458 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SKP1 GHR 25348397 N/A physical interaction ComPPI
PTPN6 GHR 14525934 25348397 9632636 N/A experimental interaction detection,in vivo ComPPI,HPRD
CRK GHR 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PTPN9 GHR 12907755 24234451 25348397 dephosphorylation reaction array technology,physical interaction,phosphatase assay ComPPI,IntAct
RNF7 GHR 25348397 N/A physical interaction ComPPI
SOCS1 GHR 10585430 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3R1 GHR 14525934 17474147 24234451 25348397 9632636 physical association experimental interaction detection,peptide array,in vivo ComPPI,HPRD,IntAct
PTPN11 GHR 10976913 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB10 GHR 14525934 25348397 9632636 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SHC1 GHR 14525934 25348397 9632636 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NCK1 GHR 17474147 24234451 25241761 25348397 physical association peptide array,physical interaction,proximity ligation assay ComPPI,IntAct
GRB2 GHR 14525934 17474147 24234451 25348397 9632636 physical association experimental interaction detection,peptide array,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN22 GHR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
RBX1 GHR 25348397 N/A physical interaction ComPPI
GHR AP2A1 10551776 25348397 27898060 N/A in vitro ComPPI,OmniPath
GHR STAT5A 14525934 24234451 25241761 25348397 8702683 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
GHR STAT5B 14525934 24234451 25241761 25348397 8923468 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
GHR SOCS2 10585430 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GHR NCOA6 10567404 10866662 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
GHR PTPN2 12907755 24234451 25348397 dephosphorylation reaction,physical association array technology,far western blotting,physical interaction,phosphatase assay,in vitro ComPPI,IntAct
GHR STAT3 14525934 25348397 8923468 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GHR IRS1 14525934 25348397 7782332 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GHR CISH 12586763 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GHR GH2 14525934 1955498 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GHR JAK1 10502458 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GHR JAK2 10502458 14525934 25348397 7540178 8063815 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GHR GH1 24234451 25348397 8943276 9353194 N/A x-ray crystallography,physical interaction,biochemical,surface plasmon resonance array ComPPI,IntAct
GHR PLCG1 17474147 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
GHR BTRC 17500058 22034227 23607312 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GHR PTPRB 12907755 19167335 24234451 25348397 dephosphorylation reaction array technology,physical interaction,phosphatase assay ComPPI,IntAct
GHR PTPN1 12907755 24234451 25348397 dephosphorylation reaction,physical association array technology,far western blotting,physical interaction,phosphatase assay ComPPI,IntAct
GHR DUSP7 12907755 24234451 25348397 dephosphorylation reaction array technology,physical interaction,phosphatase assay ComPPI,IntAct
GHR PTPN3 12907755 24234451 25348397 dephosphorylation reaction,physical association array technology,far western blotting,physical interaction,phosphatase assay ComPPI,IntAct
GHR PTPN13 25348397 N/A physical interaction ComPPI
GHR STUB1 22433856 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GHR FBXW11 25348397 N/A physical interaction ComPPI
GHR SRPK2 25348397 N/A physical interaction ComPPI
GHR NEDD8 25348397 N/A physical interaction ComPPI
GHR ELOC 25348397 N/A physical interaction ComPPI
GHR ELOB 25348397 N/A physical interaction ComPPI
GHR CUL1 25348397 N/A physical interaction ComPPI
GHR FBXO31 25348397 N/A physical interaction ComPPI
GHR PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GHR PTPRK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GHR PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GHR PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GHR GHR 14525934 16116438 24234451 8943276 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,experimental interaction detection,fluorescent resonance energy transfer HPRD,IntAct
PLCG1 GHR 17474147 27898060 N/A N/A OmniPath
PTPN1 GHR 12907755 27898060 N/A N/A OmniPath
MAPK9 GHR 27898060 8647880 9121492 N/A N/A OmniPath
GHR IGF1R 25211187 27898060 N/A N/A OmniPath
GHR STAT5A 10582086 25241761 27898060 8702683 stimulant N/A OmniPath
GHR JAK1 10502458 27898060 stimulant N/A OmniPath
GHR TYK2 10502458 27898060 stimulant N/A OmniPath
JAK2 GHR 10502458 21347402 24280222 27898060 7540178 8063815 8647880 9121492 stimulant N/A OmniPath
GHR JAK2 10502458 17312100 21347402 24280222 27898060 7540178 8063815 9211920 stimulant N/A OmniPath
SOCS2 GHR 10585430 12135564 16675548 21980433 25505247 27898060 inhibition N/A OmniPath
GHR SOCS2 10585430 12135564 16675548 21980433 25505247 27898060 N/A N/A OmniPath
GH1 GHR 17500058 1935820 21889455 24280222 27898060 7862673 8943276 9353194 9571026 stimulant N/A OmniPath
PTPRB GHR 12907755 19167335 27898060 inhibition N/A OmniPath
GHR CISH 10585430 12586763 25505247 27898060 N/A N/A OmniPath
CISH GHR 10585430 12586763 25505247 27898060 inhibition N/A OmniPath
PTPN3 GHR 12907755 27898060 N/A N/A OmniPath
PTPN9 GHR 12907755 27898060 inhibition N/A OmniPath
DUSP7 GHR 12907755 27898060 inhibition N/A OmniPath

Visualization










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