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GENE：GRAP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GRAP2
FullNmae GRB2 related adaptor protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4563
EnsembleID ENSG00000100351
Uniprot O75791

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GRAP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GRAP2 GO:0001784,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005768,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0007165,GO:0007265,GO:0007267,GO:0043408

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GRAP2 hsa:9402 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GRAP2 ERBB2 20005715 interaction type N/A PSP,SignaLink
GRAP2 CSF1R 18988627 20005715 9857184 interaction type N/A PSP,SignaLink
GRAP2 CD28 20005715 interaction type N/A PSP
GRAP2 MAP4K1 20005715 interaction type N/A PSP
GRAP2 MAP4K1 11313918 15100220 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR GRAP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 GRAP2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GRAP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 GRAP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GRAP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 GRAP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 GRAP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GRAP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GRAP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000A9FB9 GRAP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 GRAP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 GRAP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 GRAP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 GRAP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 GRAP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D GRAP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 GRAP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005485E8 GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004818BD GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C GRAP2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
USP8 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 USP8 25361965 interaction type N/A PTMCode2
GRAP2 STAMBP 25361965 interaction type N/A PTMCode2
STAMBP GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 GAB3 25361965 interaction type N/A PTMCode2
GAB3 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 SHC1 25361965 interaction type N/A PTMCode2
SHC1 GRAP2 25361965 interaction type N/A PTMCode2
SOS2 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 SOS2 25361965 interaction type N/A PTMCode2
CCNDBP1 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 CCNDBP1 25361965 interaction type N/A PTMCode2
LCP2 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 LCP2 25361965 interaction type N/A PTMCode2
GAB1 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 GAB1 25361965 interaction type N/A PTMCode2
GAB2 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 GAB2 25361965 interaction type N/A PTMCode2
KHDRBS1 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 KHDRBS1 25361965 interaction type N/A PTMCode2
CD28 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 CD28 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK GRAP2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RBPMS GRAP2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GOLGA2 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
MOS GRAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCP2 GRAP2 10021361 10224278 12176364 12773374 14525934 15929943 16189514 17010654 17235283 20534575 21516116 24234451 25348397 25416956 27107012 29997244 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,luminescence based mammalian interactome mapping,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
PRKAA2 GRAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRY2 GRAP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP4-12 GRAP2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
KRTAP4-11 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
LAT GRAP2 10021361 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ZSCAN21 GRAP2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MKRN3 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
TNIP1 GRAP2 25348397 N/A physical interaction ComPPI
KHDRBS2 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
RINT1 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
PNMA1 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
RACK1 GRAP2 10820259 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ERBB2 GRAP2 16273093 24234451 25241761 25348397 physical association protein array,physical interaction,proximity ligation assay ComPPI,IntAct
CBL GRAP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SYK GRAP2 25348397 N/A physical interaction ComPPI
SHB GRAP2 12084069 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CBLB GRAP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BLNK GRAP2 12176364 12773374 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KIT GRAP2 14525934 24234451 24728074 25348397 9872323 N/A experimental interaction detection,fluorescence polarization spectroscopy,in vitro ComPPI,HPRD,IntAct
GRAP2 PRPH2 11641407 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRAP2 CD28 10820259 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GRAP2 SHC1 14525934 25348397 9872323 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRAP2 SOS2 10820259 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
GRAP2 MAP4K1 11313918 14525934 15100220 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRAP2 KHDRBS1 10820259 14525934 25348397 9872323 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRAP2 GAB2 11997510 12176364 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
GRAP2 CCNDBP1 10801854 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GRAP2 GAB3 11997510 12773374 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRAP2 GFAP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GRAP2 YWHAE 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GRAP2 BEND5 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GRAP2 ZBTB7B 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GRAP2 LAX1 12359715 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRAP2 STAMBP 10224278 12176364 12773374 14525934 16189514 16730941 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid ComPPI,HPRD,IntAct
GRAP2 USP8 12176364 12773374 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRAP2 FASLG 11741599 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRAP2 CSF1R 14525934 24234451 25241761 25348397 9857184 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
GRAP2 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GRAP2 EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
GRAP2 CDC27 25348397 N/A physical interaction ComPPI
GRAP2 ANAPC5 25348397 N/A physical interaction ComPPI
GRAP2 ITCH 25348397 N/A physical interaction ComPPI
GRAP2 GAREM1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRAP2 TRIM68 25348397 N/A physical interaction ComPPI
GRAP2 SNX18 25348397 N/A physical interaction ComPPI
GRAP2 ANAPC1 25348397 N/A physical interaction ComPPI
GRAP2 ANAPC16 25348397 N/A physical interaction ComPPI
GRAP2 NAGK 25348397 N/A physical interaction ComPPI
GRAP2 CDC23 25348397 N/A physical interaction ComPPI
GRAP2 ANAPC7 25348397 N/A physical interaction ComPPI
GRAP2 ANAPC2 25348397 N/A physical interaction ComPPI
GRAP2 IFNAR2 25348397 N/A physical interaction ComPPI
GRAP2 RIN3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GRAP2 ABL1 25348397 N/A physical interaction ComPPI
GRAP2 ASAP1 16636290 24234451 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
GRAP2 FYB1 22074159 24234451 25348397 association pull down ComPPI,IntAct
GRAP2 AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GRAP2 LATS2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 IKZF3 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 TRAF1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 DNM2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 IHO1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 DVL2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 KRT13 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 ZNF526 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 COG6 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 LNX1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 WWP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 BAG4 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 TFIP11 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 MAGED1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
GRAP2 ZNF319 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRAP2 KPRP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRAP2 SH2D4A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRAP2 RAVER1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRAP2 PBLD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRAP2 PRR35 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GAB1 GRAP2 10913131 12176364 12773374 14525934 24234451 24728074 25348397 26186194 27898060 9878555 physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
LNX2 GRAP2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
PTPN23 GRAP2 21179510 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,far western blotting,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct

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