GENE：HIC1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HIC1 |
| FullNmae | HIC ZBTB transcriptional repressor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4909 |
| EnsembleID | ENSG00000177374 |
| Uniprot | Q14526 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HIC1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HIC1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HIC1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HIC1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HIC1 | GO:0000122,GO:0000122,GO:0000785,GO:0000981,GO:0001227,GO:0003700,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008630,GO:0016055,GO:0030178,GO:0042826,GO:0043517,GO:0043565,GO:0046872,GO:1990837 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | HIC1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | HIC1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | HIC1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | HIC1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | HIC1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | HIC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | HIC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | HIC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | HIC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | HIC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | HIC1 | 19491197 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SIRT1 | HIC1 | 22510409 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | HIC1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | HIC1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002394F5 | HIC1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | HIC1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C403E | HIC1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035CC3E | HIC1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005481D | HIC1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000913AC | HIC1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | HIC1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTBP1 | HIC1 | 25361965 | interaction type | N/A | PTMCode2 |
| HIC1 | CTBP1 | 25361965 | interaction type | N/A | PTMCode2 |
| CTBP2 | HIC1 | 25361965 | interaction type | N/A | PTMCode2 |
| HIC1 | CTBP2 | 25361965 | interaction type | N/A | PTMCode2 |
| HIC1 | ARID1A | 25361965 | interaction type | N/A | PTMCode2 |
| ARID1A | HIC1 | 25361965 | interaction type | N/A | PTMCode2 |
| HIC1 | CTNNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| CTNNB1 | HIC1 | 25361965 | interaction type | N/A | PTMCode2 |
| HIC1 | SMARCA4 | 25361965 | interaction type | N/A | PTMCode2 |
| SMARCA4 | HIC1 | 25361965 | interaction type | N/A | PTMCode2 |
| SIRT1 | HIC1 | 25361965 | interaction type | N/A | PTMCode2 |
| HIC1 | SIRT1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIAS2 | HIC1 | 17283066 23704280 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| UBE2I | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| EZH2 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| SP1 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| PIAS1 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| MECOM | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| CTBP1 | HIC1 | 12052894 14525934 16762039 17213307 19486893 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction | ComPPI,HPRD,IntAct,OmniPath |
| CTBP2 | HIC1 | 19486893 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| HDAC4 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| TCF7L2 | HIC1 | 16724116 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,imaging technique | ComPPI,IntAct |
| RBBP4 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| CTNNB1 | HIC1 | 16724116 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,imaging technique | ComPPI,IntAct |
| MTA1 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| PIAS4 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT1 | HIC1 | 14525934 16269335 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction | ComPPI,HPRD,IntAct |
| EED | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| PIAS3 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| MBD3 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| STAT3 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| HIC2 | HIC1 | 11554746 24234451 25348397 27898060 | physical association | two hybrid,physical interaction | ComPPI,IntAct,OmniPath |
| SENP3 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| ARID1A | HIC1 | 19486893 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| SUZ12 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| PHF1 | HIC1 | 25348397 | N/A | physical interaction | ComPPI |
| HIC1 | CHD3 | 25348397 | N/A | physical interaction | ComPPI |
| HIC1 | PHF19 | 25348397 | N/A | physical interaction | ComPPI |
| HIC1 | HDAC1 | 12052894 14525934 | N/A | experimental interaction detection | HPRD |
| HIC1 | HIC1 | 10611298 12052894 14525934 16724116 24234451 | physical association | two hybrid,experimental interaction detection,two hybrid | HPRD,IntAct |
| TP53 | HIC1 | 18431400 27898060 | stimulant | N/A | OmniPath |
| E2F1 | HIC1 | 19015639 19491197 27898060 | stimulant | N/A | OmniPath |
| HIC1 | E2F1 | 19015639 19491197 27898060 | inhibition | N/A | OmniPath |
| SMARCA4 | HIC1 | 19015639 27898060 | stimulant | N/A | OmniPath |
| HIC1 | STAT3 | 24067369 27898060 | inhibition | N/A | OmniPath |