Gene Information gene info

  1. Home

GENE：LATS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LATS1
FullNmae large tumor suppressor kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6514
EnsembleID ENSG00000131023
Uniprot O95835

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LATS1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LATS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LATS1 GO:0000082,GO:0000086,GO:0000287,GO:0000819,GO:0000922,GO:0000922,GO:0001827,GO:0001828,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005815,GO:0005829,GO:0006468,GO:0009755,GO:0017015,GO:0018105,GO:0019901,GO:0030216,GO:0030331,GO:0030496,GO:0030833,GO:0033138,GO:0033146,GO:0035329,GO:0035329,GO:0035329,GO:0043065,GO:0043254,GO:0045736,GO:0046620,GO:0051220,GO:0051301,GO:0060644,GO:0090090,GO:0106310,GO:1900181,GO:2000058

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LATS1 hsa:9113 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
LATS1 hsa:9113 path:hsa04392 Hippo signaling pathway - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP LATS1 21832049 23180781 physical association protein array InnateDB
LATS1 MOB1B 11278283 15688006 18328708 19739119 24243840 29145629 9545236 physical association inferred by curator Reactome
LATS1 MOB1A 11278283 15688006 18328708 19739119 24243840 29145629 9545236 physical association inferred by curator Reactome
LATS1 STK3 11278283 15688006 29145629 enzymatic reaction inferred by curator Reactome
LATS1 STK4 11278283 15688006 29145629 9545236 enzymatic reaction inferred by curator Reactome
LATS1 LATS1 20048001 21808241 22658639 26467481 phosphorylation reaction,down-regulates,down-regulates quantity by destabilization N/A Signor

Source Target Pmid Interactiontype Methods Database
E2F4 LATS1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 LATS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LATS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LATS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LATS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LATS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LATS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LATS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 LATS1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D LATS1 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00000393C7 LATS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC LATS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 LATS1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LATS1 INCENP 22135298 phosphorylation N/A PhosphoSite
LATS1 CDC26 22135298 phosphorylation N/A PhosphoSite
LATS1 LATS1 22135298 phosphorylation N/A PhosphoSite
LATS1 RAF1 22135298 phosphorylation N/A PhosphoSite
LATS1 KIF23 22135298 phosphorylation N/A PhosphoSite
LATS1 YAP1 22135298 phosphorylation N/A PhosphoSite
CDK1 LATS1 22135298 phosphorylation N/A PhosphoSite
STK3 LATS1 22135298 phosphorylation N/A PhosphoSite
NUAK2 LATS1 22135298 phosphorylation N/A PhosphoSite
NUAK1 LATS1 22135298 phosphorylation N/A PhosphoSite
LATS1 ZYX 25361965 interaction type N/A PTMCode2
ZYX LATS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 LATS1 25348397 N/A physical interaction ComPPI
UBE2I LATS1 25348397 N/A physical interaction ComPPI
PKP4 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP1R13B LATS1 25348397 N/A physical interaction ComPPI
PALS1 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP1CC LATS1 25348397 N/A physical interaction ComPPI
LDOC1 LATS1 25348397 N/A physical interaction ComPPI
LZTS2 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ALPP LATS1 25348397 N/A physical interaction ComPPI
AMOT LATS1 24234451 24255178 24366813 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MOB3C LATS1 25348397 N/A physical interaction ComPPI
XIAP LATS1 25348397 N/A physical interaction ComPPI
DCUN1D1 LATS1 25348397 N/A physical interaction ComPPI
KRT31 LATS1 25348397 N/A physical interaction ComPPI
RAC1 LATS1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HSP90AB1 LATS1 25348397 N/A physical interaction ComPPI
MOAP1 LATS1 25348397 N/A physical interaction ComPPI
SMURF2 LATS1 25348397 N/A physical interaction ComPPI
NF2 LATS1 24012335 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
ZYX LATS1 10831611 14525934 24234451 25348397 colocalization,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct
SIAH2 LATS1 24234451 25348397 25438054 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRC LATS1 25348397 N/A physical interaction ComPPI
PPP1R12A LATS1 25348397 N/A physical interaction ComPPI
WWP1 LATS1 25348397 N/A physical interaction ComPPI
MAGI1 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAV1 LATS1 25348397 N/A physical interaction ComPPI
PLK1 LATS1 25348397 N/A physical interaction ComPPI
PPP1CA LATS1 25348397 N/A physical interaction ComPPI
MYC LATS1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MAGI3 LATS1 25348397 N/A physical interaction ComPPI
EIF4EBP1 LATS1 25348397 N/A physical interaction ComPPI
PARD3 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
WWC1 LATS1 25348397 N/A physical interaction ComPPI
TRAF1 LATS1 25348397 N/A physical interaction ComPPI
MDM2 LATS1 25348397 N/A physical interaction ComPPI
CDK2 LATS1 24234451 25218637 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL4A LATS1 25348397 N/A physical interaction ComPPI
RAF1 LATS1 25348397 N/A physical interaction ComPPI
YAP1 LATS1 22863277 24234451 24255178 24366813 25283809 25348397 25751139 phosphorylation reaction,association anti tag coimmunoprecipitation,isothermal titration calorimetry,physical interaction,protein kinase assay,tandem affinity purification ComPPI,IntAct
RASSF1 LATS1 25348397 N/A physical interaction ComPPI
SSX2IP LATS1 25348397 N/A physical interaction ComPPI
ITCH LATS1 21212414 21383157 23564455 24107629 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PTEN LATS1 25348397 N/A physical interaction ComPPI
STK11 LATS1 24234451 24362629 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STK4 LATS1 14525934 15688006 24012335 24234451 25348397 colocalization experimental interaction detection,fluorescence microscopy,in vitro ComPPI,HPRD,IntAct
WWOX LATS1 25348397 N/A physical interaction ComPPI
MAST2 LATS1 25348397 N/A physical interaction ComPPI
AJUBA LATS1 25348397 N/A physical interaction ComPPI
PTPN13 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HTRA2 LATS1 16007220 17130845 22641346 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD4 LATS1 25348397 N/A physical interaction ComPPI
TJP2 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LIMK1 LATS1 14525934 15220930 24234451 25348397 colocalization,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct
TAZ LATS1 25348397 N/A physical interaction ComPPI
ASS1 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TFIP11 LATS1 25348397 N/A physical interaction ComPPI
SMURF1 LATS1 25348397 N/A physical interaction ComPPI
WWTR1 LATS1 20412773 22078877 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
STK3 LATS1 25348397 N/A physical interaction ComPPI
KIRREL1 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CGN LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ESR1 LATS1 25348397 N/A physical interaction ComPPI
LATS1 CDK1 12372621 14525934 24234451 25218637 25348397 9988268 association,physical association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
LATS1 LATS2 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 SAV1 25348397 N/A physical interaction ComPPI
LATS1 AURKB 25348397 N/A physical interaction ComPPI
LATS1 MOB1A 19739119 24234451 24255178 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 MOB1B 19739119 24234451 24255178 24366813 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 MOB3B 25348397 N/A physical interaction ComPPI
LATS1 MOB4 25348397 N/A physical interaction ComPPI
LATS1 NPHP4 25348397 N/A physical interaction ComPPI
LATS1 APP 25348397 N/A physical interaction ComPPI
LATS1 FOXL2 20407010 25348397 27898060 N/A physical interaction ComPPI,OmniPath
LATS1 NUAK1 19927127 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LATS1 NUAK2 25348397 N/A physical interaction ComPPI
LATS1 PPP1R11 25348397 N/A physical interaction ComPPI
LATS1 PPP6R3 25348397 N/A physical interaction ComPPI
LATS1 AMOTL1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 CEP131 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 CCP110 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 CEP152 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 CEP192 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 CNTROB 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 DNAJC11 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 PATJ 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 KIAA1549 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 LIMD1 20303269 24234451 24255178 25127217 25348397 27898060 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct,OmniPath
LATS1 OFD1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 PTPN14 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 RAB35 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 ENTR1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 SEC16A 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 SIPA1L2 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 CEP76 25348397 N/A physical interaction ComPPI
LATS1 FSD2 25348397 N/A physical interaction ComPPI
LATS1 CBY2 25348397 N/A physical interaction ComPPI
LATS1 PABPN1 25348397 N/A physical interaction ComPPI
LATS1 WTIP 25348397 N/A physical interaction ComPPI
LATS1 WWC2 25348397 N/A physical interaction ComPPI
LATS1 WWC3 25348397 N/A physical interaction ComPPI
LATS1 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LATS1 KATNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LATS1 TNFAIP8 25348397 N/A physical interaction ComPPI
LATS1 USP9X 25348397 N/A physical interaction ComPPI
LATS1 SCRIB 24234451 24362629 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LATS1 MARK1 24234451 24362629 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LATS1 DCAF1 24234451 25026211 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,pull down,ubiquitinase assay ComPPI,IntAct
LATS1 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
CDC26 LATS1 25348397 N/A physical interaction ComPPI
LATS1 LATS1 10831611 14525934 N/A experimental interaction detection HPRD
LATS1 WWTR1 20412773 21555462 21808241 22078877 22658639 27898060 inhibition N/A OmniPath
PRKD1 LATS1 15688006 27898060 N/A N/A OmniPath
LATS1 KIF23 22580824 25658096 25786116 27898060 N/A N/A OmniPath
LATS1 YAP1 15302935 17889669 17974916 18158288 18220336 18413746 18640976 18669648 20048001 20841485 21041411 21383157 22641346 22658639 22863277 24107629 24255178 24366813 25283809 27898060 inhibition,stimulant N/A OmniPath
STK4 LATS1 15688006 24012335 27898060 stimulant N/A OmniPath
STK3 LATS1 15688006 17379520 19962312 22195963 26108669 27898060 stimulant N/A OmniPath
NUAK1 LATS1 18669648 18691976 19369195 19413330 19690332 19927127 27898060 inhibition N/A OmniPath
CDK1 LATS1 12372621 15688006 18691976 25218637 27898060 9988268 stimulant N/A OmniPath
NF2 LATS1 24012335 26045165 27898060 stimulant N/A OmniPath
MOB1B LATS1 16674920 18328708 19739119 21084559 24255178 24366813 27898060 stimulant N/A OmniPath
MOB1A LATS1 16061636 16674920 19739119 20624913 21084559 24255178 27898060 stimulant N/A OmniPath
NUAK2 LATS1 18669648 18691976 19369195 19413330 19690332 19927127 27898060 inhibition N/A OmniPath

Visualization










  Return