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GENE：LGR5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LGR5
FullNmae leucine rich repeat containing G protein-coupled receptor 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4504
EnsembleID ENSG00000139292
Uniprot O75473

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LGR5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LGR5 GO:0001942,GO:0004888,GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0005886,GO:0007186,GO:0007189,GO:0007190,GO:0008528,GO:0009994,GO:0016500,GO:0032588,GO:0042127,GO:0048839,GO:0090263,GO:0090263,GO:2001013

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LGR5 hsa:8549 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR LGR5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LGR5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LGR5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LGR5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 LGR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
OLIG2 LGR5 23793848 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 LGR5 21436631 trascriptional regulation,stimulation inferred by curator TFlink
TCF4 LGR5 21436631 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E0AEA LGR5 23619912 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000D0BB4 LGR5 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 LGR5 22291592 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NTRK1 LGR5 25348397 N/A physical interaction ComPPI
RSPO3 LGR5 21693646 27898060 stimulant N/A OmniPath

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