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GENE：MECOM

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MECOM
FullNmae MDS1 and EVI1 complex locus
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3498
EnsembleID ENSG00000085276
Uniprot Q03112

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MECOM pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MECOM immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MECOM GO:0000978,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006915,GO:0016607,GO:0032259,GO:0043069,GO:0045892,GO:0045893,GO:0045944,GO:0046329,GO:0046872,GO:0046974,GO:0051726,GO:0070828,GO:0071425,GO:0140938,GO:0140947,GO:0140948

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MECOM hsa:2122 path:hsa00310 Lysine degradation - Homo sapiens (human)
MECOM hsa:2122 path:hsa01100 Metabolic pathways - Homo sapiens (human)
MECOM hsa:2122 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MECOM hsa:2122 path:hsa05200 Pathways in cancer - Homo sapiens (human)
MECOM hsa:2122 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MECOM CSNK2A1 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM CSNK2B 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM XRCC5 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM XRCC6 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM PRKDC 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM MSH2 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM RUVBL2 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM RAD50 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM HNRNPF 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM HNRNPU 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMC1A 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMC2 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMC3 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM RBBP4 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM LMNA 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM HDAC1 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM HDAC2 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMARCE1 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMARCC2 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM PARP1 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM PPP1CA 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM MRE11 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMARCA5 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM RPS19 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM TP53BP1 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM MSH3 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMARCA4 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM EHMT2 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM KAT2A 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
MECOM SMAD3 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR MECOM 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 MECOM 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MECOM 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MECOM 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 MECOM 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MECOM 14555651 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MECOM 18971253 22689058 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MECOM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 MECOM 22689058 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 MECOM 25416803 27617961 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,northern blot,rna immunoprecipitation,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 MECOM 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I MECOM 25348397 N/A physical interaction ComPPI
UXT MECOM 17635584 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down ComPPI,IntAct
SMAD4 MECOM 25348397 N/A physical interaction ComPPI
JUNB MECOM 22308434 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EHMT2 MECOM 25348397 N/A physical interaction ComPPI
TLE1 MECOM 25348397 N/A beta galactosidase complementation ComPPI
SMAD1 MECOM 25348397 N/A physical interaction ComPPI
JUN MECOM 22308434 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CREBBP MECOM 11568182 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD2 MECOM 25348397 N/A physical interaction ComPPI
FOSL2 MECOM 22308434 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD3 MECOM 14525934 25348397 9665135 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MECOM CTBP1 11313276 11328817 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MECOM CTBP2 14525934 25348397 9724649 N/A experimental interaction detection,in vitro ComPPI,HPRD
MECOM HDAC4 11568182 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MECOM KAT2B 11568182 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MECOM HDAC1 11552981 11568182 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MECOM MBD3 25348397 N/A physical interaction ComPPI
MECOM SUV39H1 25348397 N/A physical interaction ComPPI
MECOM SIRT1 21555002 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
MECOM ELAVL1 25348397 N/A physical interaction ComPPI
MECOM PIAS4 25348397 N/A physical interaction ComPPI
MECOM PRMT1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MECOM SPDEF 25348397 N/A physical interaction ComPPI
MECOM NLRP14 25348397 N/A physical interaction ComPPI
MECOM PIK3R3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
MECOM RABGAP1L 25348397 N/A physical interaction ComPPI
MECOM RABGAP1L 25348397 N/A physical interaction ComPPI
MECOM MED23 25348397 N/A physical interaction ComPPI
MECOM HIC1 25348397 N/A physical interaction ComPPI
MECOM FOXJ2 25348397 N/A physical interaction ComPPI
MECOM ERMAP 25348397 N/A physical interaction ComPPI
MECOM L3MBTL1 25348397 N/A physical interaction ComPPI
MECOM FOS 22308434 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MECOM YY1 22308434 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MECOM FOSB 22308434 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SOX2 MECOM 25348397 N/A physical interaction ComPPI
MECOM MECOM 14525934 14603251 N/A experimental interaction detection,two hybrid HPRD
CSNK2A1 MECOM 17525332 23858473 27898060 N/A N/A OmniPath
MECOM SMAD3 27898060 9665135 inhibition N/A OmniPath

Visualization










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