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GENE：MMP14

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MMP14
FullNmae matrix metallopeptidase 14
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7160
EnsembleID ENSG00000157227
Uniprot P50281

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MMP14 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MMP14 GO:0001501,GO:0001525,GO:0001541,GO:0001666,GO:0001935,GO:0001958,GO:0004175,GO:0004222,GO:0004222,GO:0004222,GO:0004252,GO:0005178,GO:0005515,GO:0005615,GO:0005615,GO:0005634,GO:0005737,GO:0005796,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0006508,GO:0006508,GO:0006979,GO:0008270,GO:0008584,GO:0009612,GO:0010831,GO:0010954,GO:0014070,GO:0016485,GO:0022617,GO:0030198,GO:0030307,GO:0030324,GO:0030335,GO:0030574,GO:0030574,GO:0031012,GO:0031410,GO:0031638,GO:0031638,GO:0035987,GO:0035988,GO:0042470,GO:0043615,GO:0043627,GO:0044354,GO:0045111,GO:0045579,GO:0045746,GO:0048701,GO:0048754,GO:0048771,GO:0048870,GO:0051895,GO:0060322,GO:0070006,GO:0070006,GO:0097094,GO:1903076,GO:1905523,GO:1990834

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MMP14 hsa:4323 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MMP14 hsa:4323 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MMP14 hsa:4323 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MMP14 MMP2 11112697 18037882 18633355 21900405 21909923 22880008 23691193 23737743 24376839 26192618 interaction type N/A ACSN
ITGA11 MMP14 17420280 17600088 19913614 20129924 25076207 26148229 26192618 interaction type N/A ACSN
PTP4A3 MMP14 23691193 24376839 26192618 27096756 27588115 interaction type N/A ACSN
MMP14 MMP14 26192618 interaction type N/A ACSN
SP1 MMP14 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 26192618 8844971 interaction type N/A ACSN
MMP14 LTBP1 21900405 21909923 23691193 24376839 26192618 interaction type N/A ACSN
MMP14 TGFB1 21900405 21909923 23691193 24376839 26192618 interaction type N/A ACSN
MMP14 DEFA1 19181662 23180781 cleavage reaction protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 MMP14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MMP14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MMP14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MMP14 17158885 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MMP14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MMP14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTNNB1 MMP14 21517265 trascriptional regulation,stimulation inferred by curator TFlink
CTNNBIP1 MMP14 14639622 trascriptional regulation,stimulation inferred by curator TFlink
EPAS1 MMP14 15592504 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 MMP14 15756447 18425363 trascriptional regulation,stimulation inferred by curator TFlink
KLF8 MMP14 23812425 trascriptional regulation,stimulation inferred by curator TFlink
MAZ MMP14 15528467 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MMP14 19303700 21627988 trascriptional regulation,stimulation inferred by curator TFlink
RELA MMP14 19303700 21627988 trascriptional regulation,stimulation inferred by curator TFlink
SP1 MMP14 10721699 15592504 17534446 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 MMP14 10721699 15592504 17534446 trascriptional regulation,stimulation inferred by curator TFlink
SRF MMP14 12654640 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 MMP14 14673954 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MMP14 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 MMP14 21351259 rna interference,inhibition array technology,experimental interaction detection miRSponge
URS0000237AF9 MMP14 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00004F4657 MMP14 21351259 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS0000096022 MMP14 25416803 26610210 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 MMP14 25416803 28383561 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS0000367985 MMP14 25416803 26620678 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000016FD1A MMP14 25416803 25549355 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000008A99 MMP14 25416803 26722463 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000032BD73 MMP14 25416803 26722242 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SRC MMP14 22135298 phosphorylation N/A PhosphoSite
PRKCG MMP14 22135298 phosphorylation N/A PhosphoSite
GORASP2 MMP14 25361965 interaction type N/A PTMCode2
MMP14 GORASP2 25361965 interaction type N/A PTMCode2
FURIN MMP14 25361965 interaction type N/A PTMCode2
MMP14 FURIN 25361965 interaction type N/A PTMCode2
TIMP2 MMP14 25361965 interaction type N/A PTMCode2
MMP14 TIMP2 25361965 interaction type N/A PTMCode2
SDC1 MMP14 25361965 interaction type N/A PTMCode2
MMP14 SDC1 25361965 interaction type N/A PTMCode2
ACAN MMP14 25361965 interaction type N/A PTMCode2
MMP14 ACAN 25361965 interaction type N/A PTMCode2
TIMP1 MMP14 25361965 interaction type N/A PTMCode2
MMP14 TIMP1 25361965 interaction type N/A PTMCode2
C1QBP MMP14 25361965 interaction type N/A PTMCode2
MMP14 C1QBP 25361965 interaction type N/A PTMCode2
MMP2 MMP14 25361965 interaction type N/A PTMCode2
MMP14 MMP2 25361965 interaction type N/A PTMCode2
ITGAV MMP14 25361965 interaction type N/A PTMCode2
MMP14 ITGAV 25361965 interaction type N/A PTMCode2
MMP14 ADI1 25361965 interaction type N/A PTMCode2
ADI1 MMP14 25361965 interaction type N/A PTMCode2
MMP14 CAV1 25361965 interaction type N/A PTMCode2
CAV1 MMP14 25361965 interaction type N/A PTMCode2
TIMP4 MMP14 25361965 interaction type N/A PTMCode2
MMP14 TIMP4 25361965 interaction type N/A PTMCode2
SPOCK1 MMP14 25361965 interaction type N/A PTMCode2
MMP14 SPOCK1 25361965 interaction type N/A PTMCode2
TIMP3 MMP14 25361965 interaction type N/A PTMCode2
MMP14 TIMP3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FHL3 MMP14 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COL1A2 MMP14 25348397 N/A protease assay ComPPI
MMP3 MMP14 25348397 N/A physical interaction ComPPI
ACTB MMP14 18164686 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
KASH5 MMP14 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MMP14 LRP1 14525934 14645246 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MMP14 TIMP2 12475252 14525934 19010413 24112707 24234451 25348397 27898060 9422789 9724659 physical association anti bait coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
MMP14 TIMP3 14525934 25348397 8663332 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP14 F12 10930399 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP14 MMP13 14525934 25348397 8663255 N/A experimental interaction detection,in vivo ComPPI,HPRD
MMP14 LUM 14525934 15466200 24234451 25304424 25348397 27898060 cleavage reaction experimental interaction detection,surface plasmon resonance,physical interaction,enzymatic study,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
MMP14 C1QBP 11773076 12220632 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MMP14 KISS1 12879005 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MMP14 CLDN1 11382769 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MMP14 SPOCK1 12810672 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP14 SPOCK3 11751414 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MMP14 ITGAV 11741954 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
MMP14 SDC1 12464176 12904296 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MMP14 MMP2 14525934 14583471 25348397 8663332 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP14 CAV1 14525934 15466865 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MMP14 ADI1 14525934 14718544 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vitro,confocal microscopy,two hybrid ComPPI,HPRD,IntAct,OmniPath
MMP14 ACAN 11854269 14525934 25348397 27898060 9688535 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
MMP14 CCL7 25348397 N/A in vitro,in vivo ComPPI
MMP14 BCAR1 14525934 18164686 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy ComPPI,HPRD,IntAct
MMP14 RRAD 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MMP14 PLLP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MMP14 FURIN 20608975 21152186 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MMP14 TIMP1 25348397 N/A physical interaction ComPPI
MMP14 FGFR4 20798051 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MMP14 FGFR2 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
MMP14 GORASP2 20608975 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
MMP14 GOLGB1 20608975 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
MMP14 TGOLN2 20608975 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
MMP14 LIMK1 21219645 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
MMP14 ENG 22296769 24234451 25348397 27898060 physical association proximity ligation assay ComPPI,IntAct,OmniPath
MMP14 EGFR 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MMP14 F11R 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 ZUP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 HSD17B13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 EBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 MSMO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MMP14 STOM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TIMP4 MMP14 11178970 14525934 N/A experimental interaction detection HPRD
SRC MMP14 17389600 18621744 19509114 20651331 22291036 27898060 N/A N/A OmniPath
PRKCG MMP14 19458085 22002060 22315223 27898060 N/A N/A OmniPath
GNRHR MMP14 17201186 27898060 stimulant N/A OmniPath
MMP14 MMP2 11857380 14583471 27898060 8663332 stimulant N/A OmniPath
CCL2 MMP14 15516694 27898060 stimulant N/A OmniPath
MMP14 MMP13 27898060 8663255 N/A N/A OmniPath
MMP14 C1QBP 11773076 12220632 27898060 N/A N/A OmniPath
MMP14 KISS1 12879005 27898060 N/A N/A OmniPath
MMP14 CCL7 10947989 12149192 27898060 N/A N/A OmniPath

Visualization










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