GENE：NTF3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NTF3 |
| FullNmae | neurotrophin 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8023 |
| EnsembleID | ENSG00000185652 |
| Uniprot | P20783 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NTF3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NTF3 | GO:0002092,GO:0005102,GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007169,GO:0007169,GO:0007267,GO:0007399,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0008083,GO:0008284,GO:0021675,GO:0030335,GO:0030424,GO:0030425,GO:0032148,GO:0033138,GO:0033138,GO:0038180,GO:0042056,GO:0042981,GO:0043406,GO:0043524,GO:0045664,GO:0048812,GO:0050731,GO:0050732,GO:0050804,GO:0050918,GO:0050930,GO:0090630 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NTF3 | hsa:4908 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| NTF3 | hsa:4908 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| NTF3 | hsa:4908 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| NTF3 | hsa:4908 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | NTF3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | NTF3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | NTF3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NTF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NTF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NTF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NTF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | NTF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | NTF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NTF3 | 7733919 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF175 | NTF3 | 19247725 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000171525 | NTF3 | 23185507 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS000009262D | NTF3 | 22019057 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000171525 | NTF3 | 23185507 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | NTF3 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MEOX2 | NTF3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| DOK6 | NTF3 | 20565848 24234451 25348397 | association | anti tag coimmunoprecipitation,pull down | ComPPI,IntAct |
| NTRK1 | NTF3 | 25348397 | N/A | physical interaction | ComPPI |
| NTRK2 | NTF3 | 14525934 25348397 8621424 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| HNRNPL | NTF3 | 25348397 | N/A | physical interaction | ComPPI |
| LAMB1 | NTF3 | 25348397 | N/A | physical interaction | ComPPI |
| PYGB | NTF3 | 25348397 | N/A | physical interaction | ComPPI |
| BDNF | NTF3 | 14525934 24234451 25348397 7703225 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| NTF3 | NTRK3 | 14525934 25348397 9488719 9973222 | N/A | experimental interaction detection,physical interaction,biochemical | ComPPI,HPRD |
| NTF3 | PYGL | 25348397 | N/A | physical interaction | ComPPI |
| NTF3 | ITIH3 | 25348397 | N/A | physical interaction | ComPPI |
| NTF3 | MAD2L1BP | 25348397 | N/A | physical interaction | ComPPI |
| NTF3 | SORCS2 | 24234451 24908487 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| NTF3 | NTRK1 | 17439940 27898060 | stimulant | N/A | OmniPath |
| POU4F3 | NTF3 | 15465029 27898060 | stimulant | N/A | OmniPath |
| NTF3 | NTRK3 | 10713102 1653651 27898060 7679912 9488719 9973222 | stimulant | N/A | OmniPath |