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GENE：PAK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAK4
FullNmae p21 (RAC1) activated kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16059
EnsembleID ENSG00000130669
Uniprot O96013

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAK4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAK4 GO:0001558,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005912,GO:0005925,GO:0006468,GO:0006915,GO:0007010,GO:0007049,GO:0007165,GO:0016310,GO:0016477,GO:0035556,GO:0043408,GO:0045766,GO:0060996,GO:0071407,GO:0098609,GO:0098641,GO:0106310,GO:2000352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAK4 hsa:10298 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PAK4 hsa:10298 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PAK4 hsa:10298 path:hsa04360 Axon guidance - Homo sapiens (human)
PAK4 hsa:10298 path:hsa04510 Focal adhesion - Homo sapiens (human)
PAK4 hsa:10298 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PAK4 hsa:10298 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PAK4 hsa:10298 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PAK4 hsa:10298 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PAK4 hsa:10298 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PAK4 LIMK1 10461188 10559936 10613909 11018042 11340065 11413130 11950587 17522712 22154077 26192618 interaction type N/A ACSN
APP PAK4 21832049 23180781 physical association protein array InnateDB
SRPK1 PAK4 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
GRB2 PAK4 20005715 interaction type N/A PSP
YWHAB PAK4 20005715 interaction type N/A PSP,SignaLink
YWHAG PAK4 20005715 interaction type N/A PSP
YWHAQ PAK4 20005715 interaction type N/A PSP,SignaLink
YWHAZ PAK4 20005715 interaction type N/A PSP
YWHAZ PAK4 15324660 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 PAK4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PAK4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PAK4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PAK4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C PAK4 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 PAK4 22766504 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 PAK4 22766504 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EC1BE PAK4 23622248 23824327 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000035CC3E PAK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D PAK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 PAK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC4BD PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C403E PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 PAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD PAK4 25416803 26399456 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004AC389 PAK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 PAK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 PAK4 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PAK4 PAK4 22135298 phosphorylation N/A PhosphoSite
PAK4 CTNNB1 22135298 phosphorylation N/A PhosphoSite
PAK4 ITGB5 22135298 phosphorylation N/A PhosphoSite
PAK4 RAN 22135298 phosphorylation N/A PhosphoSite
PAK4 TP53 22135298 phosphorylation N/A PhosphoSite
PAK4 LIMK1 22135298 phosphorylation N/A PhosphoSite
PAK4 ESR1 22135298 phosphorylation N/A PhosphoSite
PAK4 STMN2 22135298 phosphorylation N/A PhosphoSite
PRKD1 PAK4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
DDX6 PAK4 25348397 N/A physical interaction ComPPI
SNW1 PAK4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L PAK4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KLHL42 PAK4 25348397 N/A physical interaction ComPPI
CDC42 PAK4 14525934 17353931 20936779 22653441 24234451 25348397 9822598 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
CDK6 PAK4 25348397 N/A physical interaction ComPPI
ITGB5 PAK4 12356872 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
YWHAG PAK4 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RAN PAK4 25348397 N/A physical interaction ComPPI
RAC1 PAK4 25348397 N/A physical interaction ComPPI
PAK5 PAK4 25348397 N/A physical interaction ComPPI
INKA1 PAK4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBY1 PAK4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GRB2 PAK4 12529371 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FGFR2 PAK4 25348397 N/A two hybrid,in vitro,in vivo ComPPI
ARHGEF11 PAK4 25348397 N/A physical interaction ComPPI
ARHGEF2 PAK4 22653441 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ITGAV PAK4 12356872 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
YWHAB PAK4 17353931 24234451 24255178 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ PAK4 14525934 15161933 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PPM1A PAK4 25348397 N/A physical interaction ComPPI
NTRK1 PAK4 25348397 N/A physical interaction ComPPI
CDH1 PAK4 25348397 N/A physical interaction ComPPI
ITGB3 PAK4 25348397 N/A physical interaction ComPPI
PXN PAK4 25348397 N/A physical interaction ComPPI
PTPN4 PAK4 25348397 N/A physical interaction ComPPI
PTPN7 PAK4 25348397 N/A physical interaction ComPPI
VCL PAK4 25348397 N/A physical interaction ComPPI
RAB3IP PAK4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XPO1 PAK4 25348397 N/A physical interaction ComPPI
YWHAQ PAK4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SRPK1 PAK4 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
EGFR PAK4 25348397 N/A physical interaction ComPPI
YWHAH PAK4 17979178 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SFN PAK4 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAE PAK4 25348397 N/A physical interaction ComPPI
PAK4 LIMK1 11413130 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PAK4 DLST 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PAK4 GATAD2A 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK4 LRRK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK4 TERF1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PAK4 POT1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PAK4 APP 25348397 N/A physical interaction ComPPI
PAK4 FBXO25 25348397 N/A physical interaction ComPPI
PAK4 SRPK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PAK4 LATS2 25348397 N/A physical interaction ComPPI
PAK4 SH3RF2 25348397 N/A physical interaction ComPPI
PAK4 HECW2 25348397 N/A physical interaction ComPPI
PAK4 PAK6 25348397 N/A physical interaction ComPPI
PAK4 CARMIL1 25348397 N/A physical interaction ComPPI
PAK4 SUPT5H 25348397 N/A physical interaction ComPPI
PAK4 GGNBP2 25348397 N/A physical interaction ComPPI
PAK4 TMPRSS11A 25348397 N/A physical interaction ComPPI
PAK4 NAA20 25348397 N/A physical interaction ComPPI
PAK4 NAA25 25348397 N/A physical interaction ComPPI
PAK4 ABL1 25348397 N/A physical interaction ComPPI
PAK4 PPM1B 25348397 N/A physical interaction ComPPI
PAK4 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PAK4 RCC2 25348397 N/A physical interaction ComPPI
PAK4 RHOU 25348397 N/A physical interaction ComPPI
PAK4 RHOV 25348397 N/A physical interaction ComPPI
PAK4 H1-1 25348397 N/A physical interaction ComPPI
PAK4 MMP2 25348397 N/A physical interaction ComPPI
PAK4 STYX 25348397 N/A physical interaction ComPPI
PAK4 MTUS2 25348397 N/A physical interaction ComPPI
PAK4 KCTD3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PAK4 KIF13B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PAK4 G3BP1 25348397 N/A physical interaction ComPPI
PAK4 EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PAK4 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PAK4 PAK4 14525934 17192257 N/A experimental interaction detection HPRD
PAK4 CTNNB1 22173096 27898060 stimulant N/A OmniPath
PAK4 STMN2 23893240 25869138 27898060 N/A N/A OmniPath
PAK4 PXN 16717130 18986306 20406887 27898060 N/A N/A OmniPath
PAK4 RAN 20805321 27898060 stimulant N/A OmniPath
PAK4 ARHGEF2 15827085 22653441 27898060 N/A N/A OmniPath
PAK4 ITGB5 12356872 20507994 27898060 stimulant N/A OmniPath

Visualization










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