Gene Information gene info

  1. Home

GENE：PHGDH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PHGDH
FullNmae phosphoglycerate dehydrogenase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8923
EnsembleID ENSG00000092621
Uniprot O43175

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PHGDH immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PHGDH GO:0004617,GO:0005829,GO:0006541,GO:0006544,GO:0006564,GO:0006566,GO:0007420,GO:0009055,GO:0009448,GO:0010468,GO:0019530,GO:0021510,GO:0021782,GO:0021915,GO:0022900,GO:0030060,GO:0031175,GO:0051287,GO:0070062,GO:0070314

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PHGDH hsa:26227 path:hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human)
PHGDH hsa:26227 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
PHGDH hsa:26227 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PHGDH hsa:26227 path:hsa01200 Carbon metabolism - Homo sapiens (human)
PHGDH hsa:26227 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ISG15 PHGDH 16009940 23180781 physical association unspecified method InnateDB
EZH2 PHGDH 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 PHGDH 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 PHGDH 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
APP PHGDH 21832049 23180781 physical association protein array InnateDB
PHGDH UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 PHGDH 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 PHGDH 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PHGDH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXA10 PHGDH 19778996 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PHGDH 18378410 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PHGDH 18378410 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 PHGDH 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 PHGDH 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C3AC1 PHGDH 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 PHGDH 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC PHGDH 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000008F0CF PHGDH 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000008A99 PHGDH 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PHGDH 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCZ PHGDH 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
VASN PHGDH 25348397 N/A physical interaction ComPPI
SNW1 PHGDH 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC73 PHGDH 25348397 N/A physical interaction ComPPI
CUL5 PHGDH 25348397 N/A physical interaction ComPPI
CDC5L PHGDH 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SAP18 PHGDH 25348397 N/A physical interaction ComPPI
LDHB PHGDH 25348397 N/A physical interaction ComPPI
ISG15 PHGDH 25348397 N/A physical interaction ComPPI
STAT1 PHGDH 25348397 N/A physical interaction ComPPI
GABARAPL2 PHGDH 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
U2AF1L5 PHGDH 25348397 N/A physical interaction ComPPI
BMI1 PHGDH 25348397 N/A physical interaction ComPPI
KEAP1 PHGDH 25348397 N/A physical interaction ComPPI
MCM2 PHGDH 25348397 N/A physical interaction ComPPI
MAP1LC3B PHGDH 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EZH2 PHGDH 25348397 N/A physical interaction ComPPI
NFATC1 PHGDH 25348397 N/A physical interaction ComPPI
PRKDC PHGDH 25348397 N/A physical interaction ComPPI
GRB2 PHGDH 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN PHGDH 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
USP7 PHGDH 25348397 N/A physical interaction ComPPI
RHOB PHGDH 19637314 24234451 25348397 physical association two hybrid ComPPI,IntAct
U2AF2 PHGDH 25348397 N/A physical interaction ComPPI
TTN PHGDH 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
VAPA PHGDH 25348397 N/A physical interaction ComPPI
CUL3 PHGDH 25348397 N/A physical interaction ComPPI
UBC PHGDH 25348397 N/A physical interaction ComPPI
RPS27A PHGDH 25348397 N/A physical interaction ComPPI
UBE2N PHGDH 25348397 N/A physical interaction ComPPI
NTRK1 PHGDH 25348397 N/A physical interaction ComPPI
VTN PHGDH 25348397 N/A physical interaction ComPPI
STIP1 PHGDH 25348397 N/A physical interaction ComPPI
PPP1CA PHGDH 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
PABPC4 PHGDH 25348397 N/A physical interaction ComPPI
MAPK13 PHGDH 19135240 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1A1 PHGDH 25348397 N/A physical interaction ComPPI
CFTR PHGDH 25348397 N/A physical interaction ComPPI
MAPK6 PHGDH 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PABPC1 PHGDH 25348397 N/A physical interaction ComPPI
ECT2 PHGDH 25348397 N/A physical interaction ComPPI
KIF20A PHGDH 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROM1 PHGDH 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO1 PHGDH 25348397 N/A physical interaction ComPPI
HUWE1 PHGDH 25348397 N/A physical interaction ComPPI
RAD23A PHGDH 25348397 N/A physical interaction ComPPI
EPN3 PHGDH 25348397 N/A physical interaction ComPPI
EPN1 PHGDH 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRSF1 PHGDH 25348397 N/A physical interaction ComPPI
CUL2 PHGDH 25348397 N/A physical interaction ComPPI
SON PHGDH 25348397 N/A physical interaction ComPPI
ITSN1 PHGDH 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 PHGDH 25348397 N/A physical interaction ComPPI
EGFR PHGDH 25348397 N/A physical interaction ComPPI
RNF2 PHGDH 25348397 N/A physical interaction ComPPI
YAP1 PHGDH 25348397 N/A physical interaction ComPPI
NCSTN PHGDH 25348397 N/A physical interaction ComPPI
OCRL PHGDH 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HDAC6 PHGDH 25348397 N/A physical interaction ComPPI
MAP1LC3A PHGDH 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
STK4 PHGDH 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PIAS4 PHGDH 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MDC1 PHGDH 25348397 N/A physical interaction ComPPI
TNFRSF1B PHGDH 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SRSF11 PHGDH 25348397 N/A physical interaction ComPPI
TCERG1 PHGDH 25348397 N/A physical interaction ComPPI
VCAM1 PHGDH 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
UTP14A PHGDH 25348397 N/A physical interaction ComPPI
RAD23B PHGDH 25348397 N/A physical interaction ComPPI
CUL7 PHGDH 25348397 N/A physical interaction ComPPI
PJA1 PHGDH 25348397 N/A physical interaction ComPPI
HDAC5 PHGDH 25348397 N/A physical interaction ComPPI
PLIN3 PHGDH 25348397 N/A physical interaction ComPPI
CAND1 PHGDH 25348397 N/A physical interaction ComPPI
ASS1 PHGDH 25348397 N/A physical interaction ComPPI
HSPE1 PHGDH 25348397 N/A physical interaction ComPPI
TRIM25 PHGDH 25348397 N/A physical interaction ComPPI
SSRP1 PHGDH 25348397 N/A physical interaction ComPPI
CRY2 PHGDH 25348397 N/A physical interaction ComPPI
SRSF5 PHGDH 25348397 N/A physical interaction ComPPI
GAK PHGDH 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ESR1 PHGDH 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
RPS6KB2 PHGDH 25348397 N/A physical interaction ComPPI
BRCA1 PHGDH 25348397 N/A physical interaction ComPPI
MAP3K3 PHGDH 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF3IP1 PHGDH 20391533 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCA5 PHGDH 25348397 N/A physical interaction ComPPI
TRA2A PHGDH 25348397 N/A physical interaction ComPPI
TRIM55 PHGDH 25348397 N/A physical interaction ComPPI
TARDBP PHGDH 25348397 N/A physical interaction ComPPI
SRSF10 PHGDH 25348397 N/A physical interaction ComPPI
THRAP3 PHGDH 25348397 N/A physical interaction ComPPI
GTF3C1 PHGDH 25348397 N/A physical interaction ComPPI
SUZ12 PHGDH 25348397 N/A physical interaction ComPPI
FUS PHGDH 25348397 N/A physical interaction ComPPI
IK PHGDH 25348397 N/A physical interaction ComPPI
HNRNPA1 PHGDH 25348397 N/A physical interaction ComPPI
MYL6 PHGDH 25348397 N/A physical interaction ComPPI
GABARAPL1 PHGDH 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CHMP2B PHGDH 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RPAP3 PHGDH 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUMO4 PHGDH 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PHGDH MEPCE 25348397 N/A physical interaction ComPPI
PHGDH FBXO25 25348397 N/A physical interaction ComPPI
PHGDH APP 25348397 N/A physical interaction ComPPI
PHGDH SURF4 25348397 N/A physical interaction ComPPI
PHGDH U2AF1 25348397 N/A physical interaction ComPPI
PHGDH UQCC3 25348397 N/A physical interaction ComPPI
PHGDH SMU1 25348397 N/A physical interaction ComPPI
PHGDH ADNP 25348397 N/A physical interaction ComPPI
PHGDH EEF1A1P5 25348397 N/A physical interaction ComPPI
PHGDH FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PHGDH CLN3 25348397 N/A physical interaction ComPPI
PHGDH CLN5 25348397 N/A physical interaction ComPPI
PHGDH FBXO6 25348397 N/A physical interaction ComPPI
PHGDH OBSL1 25348397 N/A physical interaction ComPPI
PHGDH CCDC8 25348397 N/A physical interaction ComPPI
PHGDH ASNS 25348397 N/A physical interaction ComPPI
PHGDH CCDC25 25348397 N/A physical interaction ComPPI
PHGDH GDPGP1 25348397 N/A physical interaction ComPPI
PHGDH GOT1 25348397 N/A physical interaction ComPPI
PHGDH GPD1L 25348397 N/A physical interaction ComPPI
PHGDH NUDT9 25348397 N/A physical interaction ComPPI
PHGDH NECAP1 25348397 N/A physical interaction ComPPI
PHGDH PGAM1 25348397 N/A physical interaction ComPPI
PHGDH PLPBP 25348397 N/A physical interaction ComPPI
PHGDH PSAT1 25348397 N/A physical interaction ComPPI
PHGDH UBE2NL 25348397 N/A physical interaction ComPPI
PHGDH UQCRFS1 25348397 N/A physical interaction ComPPI
PHGDH SLC33A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHGDH GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHGDH TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHGDH OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHGDH RC3H1 25348397 N/A physical interaction ComPPI
PHGDH PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
ADH5 PHGDH 25348397 N/A physical interaction ComPPI
MTHFD1 PHGDH 25348397 N/A physical interaction ComPPI
PSPH PHGDH 25348397 N/A physical interaction ComPPI
TYMS PHGDH 25348397 N/A physical interaction ComPPI
DUX4L9 PHGDH 24234451 26816005 association pull down IntAct
METTL3 PHGDH 24234451 29507755 association anti tag coimmunoprecipitation IntAct
L1TD1 PHGDH 24234451 25702638 association anti bait coimmunoprecipitation IntAct
PRKCZ PHGDH 23374352 27898060 N/A N/A OmniPath
ISG15 PHGDH 16009940 27898060 N/A N/A OmniPath

Visualization










  Return