Gene Information gene info

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GENE：PTPN12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPN12
FullNmae protein tyrosine phosphatase non-receptor type 12
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9645
EnsembleID ENSG00000127947
Uniprot Q05209

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPN12 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PTPN12 GO:0002102,GO:0004721,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0006470,GO:0017124,GO:0035335,GO:0035335,GO:0042058,GO:0042058,GO:0042246,GO:0042995,GO:0071364,GO:0071364,GO:1901185,GO:2000587

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PSTPIP1 PTPN12 14707117 26192618 association N/A ACSN
APP PTPN12 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR PTPN12 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 PTPN12 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PTPN12 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000012A1DD PTPN12 16762633 \N rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000012A1DD PTPN12 16762633 18927107 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr miR2Disease,TarBase
URS00000ED600 PTPN12 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000020CEC2 PTPN12 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD PTPN12 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA PTPN12 22135298 phosphorylation N/A PhosphoSite
MAPK3 PTPN12 22135298 phosphorylation N/A PhosphoSite
CDK2 PTPN12 22135298 phosphorylation N/A PhosphoSite
MAPK1 PTPN12 22135298 phosphorylation N/A PhosphoSite
PRKCA PTPN12 22135298 phosphorylation N/A PhosphoSite
CSK PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 CSK 25361965 interaction type N/A PTMCode2
PTPN12 GAB1 25361965 interaction type N/A PTMCode2
GAB1 PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 INSR 25361965 interaction type N/A PTMCode2
INSR PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 PTK2B 25361965 interaction type N/A PTMCode2
PTK2B PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 GRB2 25361965 interaction type N/A PTMCode2
GRB2 PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 ABL1 25361965 interaction type N/A PTMCode2
ABL1 PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 WAS 25361965 interaction type N/A PTMCode2
WAS PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 NEDD9 25361965 interaction type N/A PTMCode2
NEDD9 PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 TGFB1I1 25361965 interaction type N/A PTMCode2
TGFB1I1 PTPN12 25361965 interaction type N/A PTMCode2
PTPN12 SHC1 25361965 interaction type N/A PTMCode2
SHC1 PTPN12 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 PTPN12 25348397 N/A physical interaction ComPPI
VASN PTPN12 25348397 N/A physical interaction ComPPI
ZFP2 PTPN12 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ANP32B PTPN12 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ROR2 PTPN12 25348397 N/A physical interaction ComPPI
WAS PTPN12 11711533 14525934 14707117 15588985 19167335 24234451 25348397 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,phosphatase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN6 PTPN12 25348397 N/A physical interaction ComPPI
ERBB2 PTPN12 19167335 21376233 24234451 25348397 dephosphorylation reaction,physical association phosphatase assay,bimolecular fluorescence complementation ComPPI,IntAct
SMAD1 PTPN12 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TEC PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTK2B PTPN12 11337490 12231407 14525934 15588985 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ERBB4 PTPN12 25348397 N/A physical interaction ComPPI
KIT PTPN12 12614164 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRKCA PTPN12 14525934 25348397 7520867 N/A experimental interaction detection,in vitro ComPPI,HPRD
LCK PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
KDR PTPN12 25348397 N/A physical interaction ComPPI
SHC1 PTPN12 11342545 11432829 12052829 14525934 19380743 24189400 24234451 24412244 25348397 7929214 8626541 association,physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
GRB2 PTPN12 14525934 21706016 24234451 25348397 9135065 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NEDD9 PTPN12 14525934 25348397 9748319 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD5 PTPN12 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FGFR2 PTPN12 25348397 N/A physical interaction ComPPI
PRKACA PTPN12 14525934 25348397 7520867 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAPA PTPN12 25348397 N/A physical interaction ComPPI
PDGFRB PTPN12 12614164 19167335 21376233 24234451 25348397 dephosphorylation reaction,physical association affinity technology,phosphatase assay,bimolecular fluorescence complementation ComPPI,IntAct
GHR PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GAB1 PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
NTRK1 PTPN12 19167335 24234451 25348397 dephosphorylation reaction physical interaction,phosphatase assay ComPPI,IntAct
DEK PTPN12 25348397 N/A physical interaction ComPPI
BAG6 PTPN12 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PDPK1 PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
WASF1 PTPN12 25348397 N/A physical interaction ComPPI
CSH1 PTPN12 25348397 N/A two hybrid,two hybrid,physical interaction ComPPI
CSH2 PTPN12 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PXN PTPN12 19167335 24234451 25348397 dephosphorylation reaction two hybrid,physical interaction,phosphatase assay,in vitro,in vivo ComPPI,IntAct
PSG9 PTPN12 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PTPN12 TGFB1I1 10092676 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PTPN12 PSTPIP1 11711533 11971877 14525934 14707117 24234451 25348397 9422760 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,imaging technique,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PTPN12 EFS 14525934 25348397 9748319 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN12 PSTPIP2 14525934 25348397 9804817 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN12 FLT3 14525934 15831474 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN12 LPXN 12674328 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN12 CSK 11158295 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PTPN12 INSR 14525934 19167335 24234451 25348397 8454633 dephosphorylation reaction experimental interaction detection,phosphatase assay,in vitro ComPPI,HPRD,IntAct
PTPN12 JAK2 11731619 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN12 CGA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PTPN12 TEX10 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PTPN12 RBM19 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PTPN12 STX16 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PTPN12 UTRN 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PTPN12 MYCBP2 25348397 N/A two hybrid ComPPI
PTPN12 BCAR1 12714323 14525934 24234451 25348397 8887669 9285683 9748319 9920935 physical association affinity chromatography technology,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
PTPN12 GSN 25348397 N/A physical interaction ComPPI
PTPN12 EGFR 20029029 21376233 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PTPN12 SORBS2 25348397 N/A physical interaction ComPPI
PTPN12 APP 25348397 N/A physical interaction ComPPI
PTPN12 IFT20 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTPN12 THAP2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTPN12 ANKS1A 25348397 N/A physical interaction ComPPI
PTPN12 EPN1 25348397 N/A physical interaction ComPPI
PTPN12 NUSAP1 25348397 N/A physical interaction ComPPI
PTPN12 PACSIN2 25348397 N/A physical interaction ComPPI
PTPN12 PLOD2 25348397 N/A physical interaction ComPPI
PTPN12 GANAB 25348397 N/A physical interaction ComPPI
PTPN12 TNS3 25348397 N/A physical interaction ComPPI
PTPN12 TRIM47 25348397 N/A physical interaction ComPPI
PTPN12 UGP2 25348397 N/A physical interaction ComPPI
PTPN12 CENPJ 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN12 NANOGP8 25348397 N/A physical interaction ComPPI
PTPN12 NANOG 25348397 N/A physical interaction ComPPI
PTPN12 FGFR4 25348397 N/A physical interaction ComPPI
PTPN12 ARHGAP10 25348397 N/A physical interaction ComPPI
PTPN12 ASAP1 25348397 N/A physical interaction ComPPI
PTPN12 AIFM1 25348397 N/A physical interaction ComPPI
PTPN12 LMTK2 25348397 N/A physical interaction ComPPI
PTPN12 AATK 25348397 N/A physical interaction ComPPI
PTPN12 ERBB3 25348397 N/A physical interaction ComPPI
PTPN12 PTK7 25348397 N/A physical interaction ComPPI
PTPN12 TRIM25 25348397 N/A physical interaction ComPPI
PTPN12 CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 MET 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 CTNNB1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 GRIN2B 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 NSF 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 TNK2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN12 FANCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN12 FRAT2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN12 CCDC180 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN12 SFRP4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN12 STX17 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN12 ZNF510 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
IGF1R PTPN12 25348397 N/A physical interaction ComPPI
DNPEP PTPN12 25348397 N/A physical interaction ComPPI
PPP3R2 PTPN12 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PTPN12 ABL1 11163214 14525934 15588985 N/A experimental interaction detection HPRD
PTPN12 SRC 18482983 27898060 N/A N/A OmniPath
PRKACA PTPN12 18669648 18767875 19651622 20068231 27898060 7520867 stimulant N/A OmniPath
PRKCA PTPN12 18669648 18767875 19651622 20068231 27898060 7520867 7909431 inhibition,stimulant N/A OmniPath
PTPN12 PTK2 10400703 11314030 11432829 19595712 27898060 9497381 inhibition N/A OmniPath
PTPN12 ABL1 11163214 15588985 27898060 inhibition N/A OmniPath
PTPN12 SHC1 11342545 11432829 12052829 19380743 24189400 24412244 27898060 7929214 8626541 8939605 inhibition N/A OmniPath
PTPN12 BCAR1 11432829 12714323 27898060 8887669 9285683 9748319 9920935 inhibition N/A OmniPath
PTPN12 INSR 10734133 19167335 27898060 8454633 inhibition N/A OmniPath
PTPN12 PSTPIP1 11711533 11971877 14707117 27898060 9422760 N/A N/A OmniPath
PTPN12 JAK2 11731619 27898060 inhibition N/A OmniPath
PTPN12 WAS 11711533 14707117 15588985 19167335 27898060 inhibition N/A OmniPath
PTPN12 GIT2 16317044 27898060 inhibition N/A OmniPath
DYRK1A PTPN12 27898060 7520867 7909431 N/A N/A OmniPath
PTPN12 PTK2B 11337490 12231407 15588985 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C1A25 PTPN12 27087310 direct interaction,inhibition N/A NPInter
URS00009BCA14 PTPN12 27087310 direct interaction,inhibition N/A NPInter

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