Gene Information gene info

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GENE：PTPN22

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPN22
FullNmae protein tyrosine phosphatase non-receptor type 22
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9652
EnsembleID ENSG00000134242
Uniprot Q9Y2R2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPN22 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPN22 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPN22 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PTPN22 GO:0002230,GO:0004725,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005737,GO:0005829,GO:0006470,GO:0006470,GO:0006629,GO:0006914,GO:0009898,GO:0010507,GO:0010628,GO:0010629,GO:0016791,GO:0017124,GO:0019900,GO:0030217,GO:0030217,GO:0031625,GO:0031663,GO:0032481,GO:0032496,GO:0032715,GO:0032717,GO:0032720,GO:0032720,GO:0032729,GO:0032817,GO:0034141,GO:0034141,GO:0034145,GO:0034145,GO:0034157,GO:0034165,GO:0035335,GO:0035644,GO:0043508,GO:0045088,GO:0048471,GO:0050852,GO:0050852,GO:0050855,GO:0050860,GO:0050868,GO:0050868,GO:0070374,GO:0070374,GO:0070433,GO:0070433,GO:0071225,GO:0071663,GO:1900227,GO:1901222,GO:1901222,GO:1902523,GO:1902523,GO:1903753,GO:1903753,GO:2000566

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GRB2 PTPN22 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR PTPN22 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PTPN22 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PTPN22 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TP73 PTPN22 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 PTPN22 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PTPN22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPN22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTPN22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PTPN22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PTPN22 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PTPN22 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000031BC7D PTPN22 23807165 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD PTPN22 22135298 phosphorylation N/A PhosphoSite
LCK PTPN22 25361965 interaction type N/A PTMCode2
PTPN22 LCK 25361965 interaction type N/A PTMCode2
CSK PTPN22 25361965 interaction type N/A PTMCode2
PTPN22 CSK 25361965 interaction type N/A PTMCode2
GRB2 PTPN22 25361965 interaction type N/A PTMCode2
PTPN22 GRB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LZTS2 PTPN22 25348397 N/A physical interaction ComPPI
WAS PTPN22 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
VCP PTPN22 16461343 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
EIF3E PTPN22 25348397 N/A physical interaction ComPPI
ERBB2 PTPN22 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CBL PTPN22 10068674 14525934 25348397 N/A anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VAV1 PTPN22 14525934 16461343 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
LCK PTPN22 14525934 16461343 19167335 21719704 24234451 25348397 dephosphorylation reaction,association experimental interaction detection,pull down,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PRKCD PTPN22 14525934 18056643 24234451 25348397 N/A experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
SKAP2 PTPN22 21719704 24234451 25348397 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,x-ray crystallography,phosphatase assay ComPPI,IntAct
GRB2 PTPN22 11882361 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,phage display,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ZAP70 PTPN22 14525934 16461343 24234451 25348397 dephosphorylation reaction,association experimental interaction detection,pull down,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PTPN22 CSK 14525934 25348397 9582365 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN22 CD3E 14525934 16461343 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN22 CD247 14525934 16461343 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN22 SPTA1 25348397 N/A physical interaction ComPPI
PTPN22 ACTA1 25348397 N/A physical interaction ComPPI
PTPN22 EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
PTPN22 SRPK2 25348397 N/A physical interaction ComPPI
PTPN22 CLK1 25348397 N/A physical interaction ComPPI
PTPN22 PSTPIP2 25348397 N/A physical interaction ComPPI
PTPN22 TBC1D31 25348397 N/A physical interaction ComPPI
PTPN22 KIF7 25348397 N/A physical interaction ComPPI
PTPN22 CEP131 25348397 N/A physical interaction ComPPI
PTPN22 PIBF1 25348397 N/A physical interaction ComPPI
PTPN22 KIAA0753 25348397 N/A physical interaction ComPPI
PTPN22 MIB1 25348397 N/A physical interaction ComPPI
PTPN22 MED4 25348397 N/A physical interaction ComPPI
PTPN22 SSX2IP 25348397 N/A physical interaction ComPPI
PTPN22 CCDC138 25348397 N/A physical interaction ComPPI
PTPN22 MAD2L1BP 25348397 N/A physical interaction ComPPI
PTPN22 NDUFB10 25348397 N/A physical interaction ComPPI
PTPN22 PRKAR2A 25348397 N/A physical interaction ComPPI
PTPN22 NDUFA9 25348397 N/A physical interaction ComPPI
PTPN22 CALR 25348397 N/A physical interaction ComPPI
PTPN22 SLC25A19 25348397 N/A physical interaction ComPPI
PTPN22 SDF4 25348397 N/A physical interaction ComPPI
PTPN22 MAIP1 25348397 N/A physical interaction ComPPI
PTPN22 SFXN4 25348397 N/A physical interaction ComPPI
PTPN22 HSPB1 25348397 N/A physical interaction ComPPI
PTPN22 RCN1 25348397 N/A physical interaction ComPPI
PTPN22 ACAD8 25348397 N/A physical interaction ComPPI
PTPN22 GLUD1 25348397 N/A physical interaction ComPPI
PTPN22 HAX1 25348397 N/A physical interaction ComPPI
PTPN22 SCO2 25348397 N/A physical interaction ComPPI
PTPN22 CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN22 PDGFRB 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN22 NTRK1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN22 PDPK1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN22 GHR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN22 PSTPIP1 24234451 25040622 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
PTPN22 TRAF3 23871208 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
AKR7A2 PTPN22 25348397 N/A physical interaction ComPPI
RPS19BP1 PTPN22 25348397 N/A physical interaction ComPPI
CALU PTPN22 25348397 N/A physical interaction ComPPI
PTPN22 PTPN22 18056643 24234451 N/A x-ray crystallography IntAct
VIM PTPN22 24234451 30021884 physical association cross-linking study IntAct
PTPN22 LCK 16461343 19167335 21719704 27898060 inhibition N/A OmniPath
PRKCD PTPN22 18056643 27898060 inhibition N/A OmniPath
PTPN22 CBL 10068674 27898060 inhibition N/A OmniPath
PTPN22 ZAP70 16461343 27898060 inhibition N/A OmniPath
PTPN22 CD247 16461343 27898060 inhibition N/A OmniPath

Visualization










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