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GENE：PTPRZ1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPRZ1
FullNmae protein tyrosine phosphatase receptor type Z1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9685
EnsembleID ENSG00000106278
Uniprot P23471

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPRZ1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PTPRZ1 GO:0002244,GO:0004725,GO:0004725,GO:0004725,GO:0004725,GO:0005001,GO:0005178,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0006470,GO:0007409,GO:0007417,GO:0007611,GO:0031641,GO:0035335,GO:0035335,GO:0043524,GO:0045202,GO:0048709,GO:0048714,GO:0070445,GO:0072534

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTPRZ1 hsa:5803 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPRZ1 ALK 17681947 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ELK1 PTPRZ1 20224786 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PTPRZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EPAS1 PTPRZ1 20224786 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171525 PTPRZ1 23807165 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
ALK PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 ALK 25361965 interaction type N/A PTMCode2
FYN PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 FYN 25361965 interaction type N/A PTMCode2
PTN PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 PTN 25361965 interaction type N/A PTMCode2
MDK PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 MDK 25361965 interaction type N/A PTMCode2
CNTN1 PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 CNTN1 25361965 interaction type N/A PTMCode2
TNR PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 TNR 25361965 interaction type N/A PTMCode2
ADD2 PTPRZ1 25361965 interaction type N/A PTMCode2
PTPRZ1 ADD2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 PTPRZ1 25348397 N/A physical interaction ComPPI
WAS PTPRZ1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
ERBB2 PTPRZ1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
LCK PTPRZ1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
VEGFA PTPRZ1 25348397 N/A physical interaction ComPPI
ITGAV PTPRZ1 20639902 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GIT1 PTPRZ1 11381105 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
ITGB3 PTPRZ1 20639902 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
CNTN1 PTPRZ1 21969550 24234451 25348397 physical association molecular sieving,pull down,x-ray crystallography,physical interaction ComPPI,IntAct
PXN PTPRZ1 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRZ1 CTNNB1 10706604 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPRZ1 FYN 14525934 15925565 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PTPRZ1 ARHGAP35 14525934 16513268 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPRZ1 PTN 10706604 14525934 16814777 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPRZ1 ALK 14525934 17681947 24234451 25348397 dephosphorylation reaction,physical association experimental interaction detection,pull down,phosphatase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PTPRZ1 MDK 10212223 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPRZ1 TNR 25348397 N/A physical interaction ComPPI
PTPRZ1 NCL 25348397 N/A physical interaction ComPPI
PTPRZ1 CSK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRZ1 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HMGB1 PTPRZ1 25348397 N/A physical interaction ComPPI
PTPRZ1 ADD2 14525934 16105548 N/A experimental interaction detection HPRD
PTPRZ1 PTPRZ1 15978577 24234451 association tox-r dimerization assay IntAct
PTPRZ1 NTRK1 18477627 27898060 N/A N/A OmniPath
PTPRZ1 ARHGAP35 15588986 16513268 27898060 N/A N/A OmniPath
MDK PTPRZ1 10212223 27898060 N/A N/A OmniPath
PTPRZ1 CNTN1 21969550 27898060 9118959 N/A N/A OmniPath
PTN PTPRZ1 10706604 16814777 25644401 27898060 stimulant N/A OmniPath
PTPRZ1 ALK 17681947 27898060 inhibition N/A OmniPath
PTPRZ1 CNTNAP1 27898060 9118959 N/A N/A OmniPath
PTPRZ1 ADD2 16105548 27898060 N/A N/A OmniPath

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