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GENE：REST

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol REST
FullNmae RE1 silencing transcription factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9966
EnsembleID ENSG00000084093
Uniprot Q13127

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
REST immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
REST GO:0000122,GO:0000122,GO:0000381,GO:0000976,GO:0000976,GO:0000978,GO:0000978,GO:0000979,GO:0001227,GO:0001227,GO:0001227,GO:0001666,GO:0002244,GO:0002931,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006355,GO:0008285,GO:0010629,GO:0017053,GO:0017053,GO:0032348,GO:0035019,GO:0043065,GO:0043068,GO:0043280,GO:0043922,GO:0045665,GO:0045665,GO:0045665,GO:0045666,GO:0045667,GO:0045892,GO:0045892,GO:0045892,GO:0045892,GO:0045893,GO:0045944,GO:0045955,GO:0046676,GO:0046872,GO:0050768,GO:0050877,GO:0060379,GO:0061629,GO:0071257,GO:0071385,GO:0071466,GO:0097150,GO:0099563,GO:1902459,GO:1902894,GO:2000065,GO:2000706,GO:2000740,GO:2000798

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
REST hsa:5978 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
REST hsa:5978 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
REST BTRC 18354482 18354483 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down InnateDB
REST FBXW11 18354482 18354483 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
REST MAD2L1 18354482 23180781 physical association anti tag coimmunoprecipitation InnateDB
REST EGR1 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
REST RPS3 23180781 24852203 physical association anti tag coimmunoprecipitation InnateDB
REST MLLT11 23180781 26341630 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 REST 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 REST 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 REST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR REST 24163104 trascriptional regulation,stimulation inferred by curator TFlink
ZNF335 REST 23178126 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D REST 19242418 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000009262D REST 18927107 19242418 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000237AF9 REST 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000006F90B REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F REST 23446348 25416803 26996236 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 REST 20371350 21572407 23446348 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000272A3D REST 20371350 21572407 23446348 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001E0AEA REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000260A3A REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E0524 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000030F801 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000085F64 REST 20371350 21572407 23446348 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD02D REST 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039D790 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA REST 20371350 21572407 22012620 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039607D REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005CE28 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A122A REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005D4F5 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C02E4 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000328C0D REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000451A1 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000043B1D REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000480E22 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B1B47 REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000025307A REST 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005DEC41 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD REST 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004407DC REST 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 REST 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F REST 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 REST 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A REST 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF REST 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 REST 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
REST SMARCE1 25361965 interaction type N/A PTMCode2
SMARCE1 REST 25361965 interaction type N/A PTMCode2
REST HTT 25361965 interaction type N/A PTMCode2
HTT REST 25361965 interaction type N/A PTMCode2
REST SMARCA4 25361965 interaction type N/A PTMCode2
SMARCA4 REST 25361965 interaction type N/A PTMCode2
REST RNF2 25361965 interaction type N/A PTMCode2
RNF2 REST 25361965 interaction type N/A PTMCode2
REST CDYL 25361965 interaction type N/A PTMCode2
CDYL REST 25361965 interaction type N/A PTMCode2
HDAC5 REST 25361965 interaction type N/A PTMCode2
REST HDAC5 25361965 interaction type N/A PTMCode2
NANOG REST 25361965 interaction type N/A PTMCode2
REST NANOG 25361965 interaction type N/A PTMCode2
SMARCC2 REST 25361965 interaction type N/A PTMCode2
REST SMARCC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 REST 25348397 N/A physical interaction ComPPI
SMARCE1 REST 12192000 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F6 REST 17468742 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
GTF2B REST 25348397 N/A physical interaction ComPPI
EHMT2 REST 17468742 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK1 REST 25348397 N/A physical interaction ComPPI
SP1 REST 25348397 N/A physical interaction ComPPI
TBP REST 15197246 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FBXW7 REST 25348397 N/A physical interaction ComPPI
HDAC4 REST 25348397 N/A physical interaction ComPPI
NCOR1 REST 17468742 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBB REST 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC REST 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
RPS27A REST 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 REST 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
BTRC REST 18354482 18354483 24234451 24760862 25299066 25348397 25453754 25515538 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
CSNK1E REST 25348397 N/A physical interaction ComPPI
SMARCA4 REST 12192000 17023429 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SIN3A REST 10491605 21693630 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SUB1 REST 25348397 N/A physical interaction ComPPI
PLK1 REST 25348397 N/A physical interaction ComPPI
GRIA2 REST 25348397 N/A physical interaction ComPPI
HTT REST 12881722 25348397 27898060 N/A in vivo ComPPI,OmniPath
HDAC2 REST 17468742 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF2 REST 17468742 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CTDSP1 REST 25348397 N/A physical interaction ComPPI
AURKA REST 25348397 N/A physical interaction ComPPI
HDAC5 REST 25348397 N/A physical interaction ComPPI
SIN3B REST 10570134 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
RCOR1 REST 17939992 24234451 25348397 association anti bait coimmunoprecipitation,two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
CDYL REST 25348397 N/A physical interaction ComPPI
FBXW2 REST 25348397 N/A physical interaction ComPPI
FBXW8 REST 25348397 N/A physical interaction ComPPI
SMARCC2 REST 12192000 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TERF2 REST 25348397 N/A physical interaction ComPPI
FBXW4 REST 25348397 N/A physical interaction ComPPI
FBXW11 REST 18354482 18354483 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SCYL1 REST 25348397 N/A physical interaction ComPPI
EIF4A3 REST 25348397 N/A physical interaction ComPPI
REST KDM5C 17468742 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
REST HDAC1 25348397 N/A physical interaction ComPPI
REST FBXW5 25348397 N/A physical interaction ComPPI
REST TEX14 25348397 N/A physical interaction ComPPI
REST FOXK2 25348397 N/A physical interaction ComPPI
H2BC5 REST 24234451 30021884 physical association cross-linking study IntAct
H2BC21 REST 24234451 30021884 physical association cross-linking study IntAct
RCOR1 REST 10449787 15897453 19394292 27898060 stimulant N/A OmniPath

Visualization










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