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GENE：SPOP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPOP
FullNmae speckle type BTB/POZ protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11254
EnsembleID ENSG00000121067
Uniprot O43791

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPOP immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SPOP GO:0000209,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0016607,GO:0030162,GO:0031463,GO:0031625,GO:0031625,GO:0043161,GO:0043161,GO:0051179,GO:0140678

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPOP hsa:8405 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRAF6 SPOP 11279055 23180781 physical association gst pull down InnateDB
SPOP TRAF1 11279055 23180781 physical association gst pull down InnateDB
MYD88 SPOP 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
DAXX SPOP 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPOP CUL3 15897469 19261606 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 SPOP 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SPOP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SPOP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SPOP 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SPOP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C SPOP 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SPOP 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPOP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004977C5 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000ED600 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5659 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FAA8C SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SPOP 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SPOP CUL3 25361965 interaction type N/A PTMCode2
CUL3 SPOP 25361965 interaction type N/A PTMCode2
SPOP TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 SPOP 25361965 interaction type N/A PTMCode2
SPOP PDX1 25361965 interaction type N/A PTMCode2
PDX1 SPOP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GCC1 SPOP 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DAXX SPOP 21573799 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,confocal microscopy ComPPI,IntAct
TRAF6 SPOP 25348397 N/A physical interaction ComPPI
BMI1 SPOP 25348397 N/A physical interaction ComPPI
UBE2D1 SPOP 25348397 N/A physical interaction ComPPI
BRMS1 SPOP 22085717 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UBE2E3 SPOP 25348397 N/A physical interaction ComPPI
AR SPOP 19762545 24508459 25274033 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NCOA3 SPOP 21577200 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
COP1 SPOP 25348397 N/A physical interaction ComPPI
PIAS1 SPOP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GLI2 SPOP 25348397 N/A physical interaction ComPPI
GLI3 SPOP 25348397 N/A physical interaction ComPPI
UBE2D2 SPOP 25348397 N/A physical interaction ComPPI
CUL3 SPOP 21577200 21988832 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
DEK SPOP 25348397 N/A physical interaction ComPPI
DUSP7 SPOP 24234451 24656772 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,physical interaction,ubiquitinase assay ComPPI,IntAct
ERF SPOP 25348397 N/A physical interaction ComPPI
FADD SPOP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GDI1 SPOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATM SPOP 25348397 N/A physical interaction ComPPI
TRAF1 SPOP 11279055 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ZBTB16 SPOP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RXRB SPOP 14525934 16189514 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BRD2 SPOP 25348397 N/A physical interaction ComPPI
RTN4 SPOP 25348397 N/A physical interaction ComPPI
SIRT2 SPOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PTEN SPOP 24234451 24656772 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,x-ray crystallography,physical interaction,ubiquitinase assay ComPPI,IntAct
GPS1 SPOP 24234451 25348397 27029275 physical association transmission electron microscopy ComPPI,IntAct
PIP4K2B SPOP 18218622 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GIT2 SPOP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MYD88 SPOP 14525934 16189514 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
DOK2 SPOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP50 SPOP 25348397 N/A physical interaction ComPPI
PDX1 SPOP 14525934 15121856 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SPOP HCST 10426994 12426564 12426565 12740575 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SPOP MACROH2A1 12183056 14525934 25348397 27898060 N/A two hybrid,two hybrid ComPPI,HPRD,OmniPath
SPOP DDIT3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SPOP DPPA2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SPOP RTN3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SPOP PIP5K1B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SPOP ESR1 25348397 N/A physical interaction ComPPI
SPOP ERG 25348397 N/A physical interaction ComPPI
SPOP PGR 25348397 N/A physical interaction ComPPI
SPOP NANOGP8 25348397 N/A physical interaction ComPPI
SPOP NANOG 25348397 N/A physical interaction ComPPI
SPOP EGLN2 25348397 N/A physical interaction ComPPI
SPOP SOST 25348397 N/A physical interaction ComPPI
SPOP ARIH1 25348397 N/A physical interaction ComPPI
SPOP MSRB3 25348397 N/A physical interaction ComPPI
SPOP BRD4 25348397 N/A physical interaction ComPPI
SPOP BRD3 25348397 N/A physical interaction ComPPI
KPNA6 SPOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SRRM1 SPOP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SPOP NCOA3 21577200 23559371 24239470 27898060 inhibition N/A OmniPath
SPOP TRAF6 11279055 27898060 N/A N/A OmniPath
MYD88 SPOP 16189514 21988832 26186194 27898060 N/A N/A OmniPath
DAXX SPOP 15240113 16524876 21573799 21988832 27898060 N/A N/A OmniPath
SPOP CUL3 15897469 16524876 19256485 19261606 1926161 21577200 21988832 22013077 22911784 25011449 25278611 27898060 stimulant N/A OmniPath

Visualization










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