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GENE：THBS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol THBS2
FullNmae thrombospondin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11786
EnsembleID ENSG00000186340
Uniprot P35442

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
THBS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
THBS2 apoptosis 34288045 Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway. retulator signature

Go Annotation:

GeneSymbol Go id
THBS2 GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005604,GO:0007155,GO:0008201,GO:0016525,GO:0016525,GO:0031091,GO:0051965,GO:0062023,GO:0062023

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
THBS2 hsa:7058 path:hsa04145 Phagosome - Homo sapiens (human)
THBS2 hsa:7058 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
THBS2 hsa:7058 path:hsa04510 Focal adhesion - Homo sapiens (human)
THBS2 hsa:7058 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
THBS2 hsa:7058 path:hsa05144 Malaria - Homo sapiens (human)
THBS2 hsa:7058 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 THBS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC THBS2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 THBS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXB7 THBS2 21183939 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000330617 THBS2 24177325 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00003E2232 THBS2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED THBS2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000042935A THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000412AC7 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000759EB8 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048F59D THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCDA3 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000381CEC THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000116F83 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 THBS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B THBS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 THBS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004929F1 THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002373FD THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000011166D THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004DEA91 THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC4BD THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000555DA6 THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 THBS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000001C659 THBS2 25416803 27157622 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
AP1G2 THBS2 25348397 N/A physical interaction ComPPI
THBS1 THBS2 25348397 N/A physical interaction ComPPI
THBS2 MMP2 10900205 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
THBS2 MMP9 10900205 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
THBS2 ZWINT 25348397 N/A physical interaction ComPPI
THBS2 PIGA 25348397 N/A physical interaction ComPPI
THBS2 FOXF2 25348397 N/A physical interaction ComPPI
THBS2 ITGB1 15292271 27898060 stimulant N/A OmniPath
THBS2 NOTCH3 19147503 27898060 N/A N/A OmniPath
THBS2 ITGA4 14699013 27898060 stimulant N/A OmniPath
THBS2 CD47 27898060 8550562 stimulant N/A OmniPath
THBS2 ITGA6 12909644 27898060 stimulant N/A OmniPath

Visualization










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