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GENE：APAF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APAF1
FullNmae apoptotic peptidase activating factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:576
EnsembleID ENSG00000120868
Uniprot O14727

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APAF1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APAF1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APAF1 apoptosis 33177505 Both EMC6 and APAF1 regulated apoptosis and inflammatory injury in pancreatic inflammatory diseases. retulator signature
APAF1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
APAF1 GO:0000166,GO:0001666,GO:0001822,GO:0001843,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0006915,GO:0006919,GO:0007399,GO:0007584,GO:0008635,GO:0008656,GO:0010659,GO:0030154,GO:0030900,GO:0031072,GO:0032991,GO:0034774,GO:0042802,GO:0042981,GO:0043065,GO:0043293,GO:0043293,GO:0043293,GO:0043531,GO:0051402,GO:0070059,GO:0070062,GO:0071560,GO:0072432,GO:0097193,GO:0097193,GO:1902510,GO:1904813,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
APAF1 hsa:317 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
APAF1 hsa:317 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
APAF1 hsa:317 path:hsa04210 Apoptosis - Homo sapiens (human)
APAF1 hsa:317 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
APAF1 hsa:317 path:hsa05010 Alzheimer disease - Homo sapiens (human)
APAF1 hsa:317 path:hsa05012 Parkinson disease - Homo sapiens (human)
APAF1 hsa:317 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
APAF1 hsa:317 path:hsa05016 Huntington disease - Homo sapiens (human)
APAF1 hsa:317 path:hsa05020 Prion disease - Homo sapiens (human)
APAF1 hsa:317 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
APAF1 hsa:317 path:hsa05134 Legionellosis - Homo sapiens (human)
APAF1 hsa:317 path:hsa05152 Tuberculosis - Homo sapiens (human)
APAF1 hsa:317 path:hsa05160 Hepatitis C - Homo sapiens (human)
APAF1 hsa:317 path:hsa05161 Hepatitis B - Homo sapiens (human)
APAF1 hsa:317 path:hsa05162 Measles - Homo sapiens (human)
APAF1 hsa:317 path:hsa05164 Influenza A - Homo sapiens (human)
APAF1 hsa:317 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
APAF1 hsa:317 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
APAF1 hsa:317 path:hsa05200 Pathways in cancer - Homo sapiens (human)
APAF1 hsa:317 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
APAF1 hsa:317 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F1 APAF1 11389439 11559530 11591730 15279786 17218262 17303408 17660363 18590585 26192618 7575488 interaction type N/A ACSN
PTMA APAF1 11864614 12522243 14622304 15087373 17377525 18439902 26192618 interaction type N/A ACSN
ACHE APAF1 11864614 12522243 14622304 15087373 17377525 18439902 22514517 26192618 interaction type N/A ACSN
AFP APAF1 11864614 12522243 14622304 15087373 17377525 18439902 26192618 interaction type N/A ACSN
ANP32A APAF1 11864614 12522243 14622304 15087373 17377525 18439902 26192618 interaction type N/A ACSN
CSE1L APAF1 11864614 12522243 14622304 15087373 17377525 18439902 26192618 interaction type N/A ACSN
APAF1 XIAP 11230124 12181739 23180781 physical association gst pull down InnateDB
CASP9 APAF1 16352606 19118655 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 APAF1 12874265 23180781 physical association anti tag coimmunoprecipitation InnateDB
APAF1 PPP1CA 17274640 23180781 physical association anti tag coimmunoprecipitation InnateDB
APAF1 CASP9 19337385 23180781 physical association two hybrid InnateDB
APAF1 APAF1 15829969 26467481 9390557 bind,up-regulates,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR APAF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 APAF1 12149244 12766778 15972851 17600109 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 APAF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 APAF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 APAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF APAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 APAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 APAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 APAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS APAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F6 APAF1 17600109 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 APAF1 18834886 trascriptional regulation,stimulation inferred by curator TFlink
SP1 APAF1 15972851 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 APAF1 15972851 trascriptional regulation,stimulation inferred by curator TFlink
TP53 APAF1 11896574 15972851 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 APAF1 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS000009262D APAF1 17991735 18829576 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D APAF1 18591254 18829576 25416803 27021436 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 APAF1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 APAF1 20584899 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection TarBase
URS000031BC7D APAF1 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS0000170CF4 APAF1 23630541 25416803 25586265 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001CC864 APAF1 24249161 24952592 25416803 26171041 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C0099 APAF1 23313552 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 APAF1 23313552 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C APAF1 23313552 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 APAF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000425000 APAF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 APAF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 APAF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 APAF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B APAF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 APAF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C0D3F APAF1 25416803 27517917 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00000EED18 APAF1 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
RPS6KA1 APAF1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
XIAP APAF1 25348397 N/A physical interaction ComPPI
CASP9 APAF1 10206961 10376594 14525934 19494828 20462491 21827945 24234451 25348397 9390557 9488720 9539746 9837928 9922454 cleavage reaction,association,physical association coimmunoprecipitation,cosedimentation,cosedimentation in solution,cosedimentation through density gradient,electron microscopy,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,protease assay,in vitro,in vivo,protease accessibility laddering ComPPI,HPRD,IntAct
CYCS APAF1 10206961 12147322 14525934 24234451 25348397 9267021 association,physical association coimmunoprecipitation,cosedimentation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
BCL2L1 APAF1 12963020 14525934 25348397 9488720 9539746 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CASP3 APAF1 11550094 14525934 21827945 24234451 25348397 cleavage reaction experimental interaction detection,protease assay,in vitro,protease accessibility laddering ComPPI,HPRD,IntAct
HSP90AA1 APAF1 25348397 N/A physical interaction ComPPI
HSPA1A APAF1 10934467 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
HSPA1B APAF1 25348397 N/A coimmunoprecipitation,in vivo ComPPI
HSP90B1 APAF1 25348397 N/A physical interaction ComPPI
CASP8 APAF1 14525934 25348397 9539746 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PPP1CA APAF1 14525934 17274640 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,antibody array ComPPI,HPRD,IntAct
YWHAE APAF1 22246185 24234451 25348397 physical association pull down ComPPI,IntAct
HSPA4 APAF1 25348397 N/A physical interaction ComPPI
APAF1 CASP4 14525934 25348397 9539746 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
APAF1 AVEN 10949025 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
APAF1 BCL2L10 10486928 14525934 25348397 27898060 9829980 9878060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
APAF1 APIP 14525934 15262985 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
APAF1 FEM1B 10764728 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
APAF1 NLRP1 11113115 14525934 17418785 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
APAF1 FAS 14525934 25348397 9267021 N/A experimental interaction detection,in vivo ComPPI,HPRD
APAF1 TRIAP1 14525934 15735003 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
APAF1 HIP1 14525934 16979168 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
APAF1 HSP90AA2P 25348397 N/A physical interaction ComPPI
APAF1 ELAVL1 25348397 N/A physical interaction ComPPI
APAF1 TOP1 25348397 N/A physical interaction ComPPI
APAF1 SHMT2 25348397 N/A physical interaction ComPPI
APAF1 ENDOV 25348397 N/A physical interaction ComPPI
APAF1 DEF8 25348397 N/A physical interaction ComPPI
APAF1 OMD 25348397 N/A physical interaction ComPPI
APAF1 WDFY3 25348397 N/A physical interaction ComPPI
APAF1 IQCN 25348397 N/A physical interaction ComPPI
APAF1 LGALS7 25348397 N/A physical interaction ComPPI
APAF1 AARSD1 25348397 N/A physical interaction ComPPI
APAF1 LYPD4 25348397 N/A physical interaction ComPPI
CRYBA4 APAF1 25348397 N/A physical interaction ComPPI
RSL1D1 APAF1 24234451 30021884 physical association cross-linking study IntAct
H3-4 APAF1 24234451 30021884 physical association cross-linking study IntAct
EIF2AK3 APAF1 16595687 27898060 inhibition N/A OmniPath
HSPA1A APAF1 10934467 27898060 inhibition N/A OmniPath
BCL2L1 APAF1 10811864 12963020 27898060 9488720 9539746 inhibition,stimulant N/A OmniPath
APAF1 CASP3 11550094 12874265 27898060 stimulant N/A OmniPath
APAF1 CASP9 10206961 10329646 10364241 10376594 10393175 10428850 10617566 10722681 10749135 11113115 11242052 15262985 15829969 16352606 19118655 19337385 19494828 19698783 20829884 27898060 9390557 9488720 9539746 9651578 9837928 9922454 stimulant N/A OmniPath
RPS6KA1 APAF1 22246185 27898060 N/A N/A OmniPath
CARD8 APAF1 11408476 27898060 inhibition N/A OmniPath
CYCS APAF1 10206961 10329646 10364241 10393175 10578178 10722681 10940292 11112785 11753565 12147322 15829969 15907471 16713569 16977332 27898060 9267021 9390557 stimulant N/A OmniPath
TP53 APAF1 11389439 11423996 11559530 27898060 stimulant N/A OmniPath
E2F1 APAF1 11389439 18319725 27898060 stimulant N/A OmniPath
EIF4G2 APAF1 11943866 27898060 stimulant N/A OmniPath
BAX APAF1 11709054 27898060 stimulant N/A OmniPath
APIP APAF1 15262985 27898060 inhibition N/A OmniPath
HSP90AB1 APAF1 10944114 27898060 inhibition N/A OmniPath
COX5B APAF1 27898060 9267021 9390557 stimulant N/A OmniPath
ANP32A APAF1 12522243 27898060 stimulant N/A OmniPath

Visualization










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