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GENE：PPM1D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPM1D
FullNmae protein phosphatase, Mg2+/Mn2+ dependent 1D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9277
EnsembleID ENSG00000170836
Uniprot O15297

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPM1D mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPM1D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPM1D GO:0000086,GO:0004674,GO:0004722,GO:0004722,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005829,GO:0005829,GO:0006306,GO:0006470,GO:0008285,GO:0009267,GO:0009314,GO:0009617,GO:0017018,GO:0030330,GO:0031507,GO:0035970,GO:0035970,GO:0045814,GO:0045814,GO:0046872,GO:0051019,GO:0051019,GO:0060260

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPM1D hsa:8493 path:hsa04115 p53 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPM1D PPM1D 11101524 15870257 17967874 19360021 19713933 26467481 dephosphorylation reaction,down-regulates,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR PPM1D 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PPM1D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PPM1D 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PPM1D 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PPM1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PPM1D 19015127 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 PPM1D 20668064 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB PPM1D 20668064 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000060B2B PPM1D 20668064 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000076995 PPM1D 21175813 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000076995 PPM1D 21175813 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 PPM1D 20668064 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS00004DA9DB PPM1D 20668064 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000060B2B PPM1D 20668064 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 PPM1D 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000272A3D PPM1D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E5ECC PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C PPM1D 25092292 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS000075C1E1 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411672 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000156390 PPM1D 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HIPK2 PPM1D 22135298 phosphorylation N/A PhosphoSite
PPM1D RPL5 25361965 interaction type N/A PTMCode2
RPL5 PPM1D 25361965 interaction type N/A PTMCode2
TP53 PPM1D 25361965 interaction type N/A PTMCode2
PPM1D TP53 25361965 interaction type N/A PTMCode2
ILK PPM1D 25361965 interaction type N/A PTMCode2
PPM1D ILK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 PPM1D 24234451 25348397 28330616 association pull down,physical interaction ComPPI,IntAct
CDC5L PPM1D 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 PPM1D 25348397 N/A physical interaction ComPPI
RAD21 PPM1D 25348397 N/A physical interaction ComPPI
ERRFI1 PPM1D 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPP4C PPM1D 18614045 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RUNX2 PPM1D 22065775 24234451 25348397 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,dephosphorylation reaction,physical interaction,phosphatase assay ComPPI,IntAct
KPNB1 PPM1D 24234451 25348397 28330616 association pull down,physical interaction ComPPI,IntAct
YWHAB PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
ACTN4 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
UBC PPM1D 25348397 N/A physical interaction ComPPI
PTGES3 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
PSMC5 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
MDM2 PPM1D 14525934 17936559 24234451 25348397 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,phosphatase assay,in vitro,in vivo ComPPI,HPRD,IntAct
CHEK2 PPM1D 25348397 N/A physical interaction ComPPI
SPAG9 PPM1D 25348397 N/A physical interaction ComPPI
PSMD2 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
NAT2 PPM1D 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSMD4 PPM1D 25348397 N/A physical interaction ComPPI
NUP153 PPM1D 25348397 N/A physical interaction ComPPI
RANBP2 PPM1D 25348397 N/A physical interaction ComPPI
RPL5 PPM1D 14525934 25348397 27898060 7649987 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
TUBB4A PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
H2AX PPM1D 20118229 24234451 25348397 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,physical interaction,phosphatase assay ComPPI,IntAct
KDM1A PPM1D 25348397 N/A physical interaction ComPPI
KPNA6 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
PARK7 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
EIF3A PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPM4 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D BEX2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D CASZ1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D DIRAS3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D DKK3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D EPSTI1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D GLCE 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D ITIH5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D LYPD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D MRC2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D OSGIN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D RHOBTB2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D NSD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPM1D TMOD3 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D TUBB6 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D G3BP1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D PSMC2 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D TUBA1C 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D NTPCR 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D GPI 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D PSMD6 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D TUBB2A 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPM1D TP53 14525934 17936559 N/A experimental interaction detection HPRD
PPM1D NCL 12185196 14525934 N/A experimental interaction detection HPRD
PPM1D SUN2 22270916 25217773 26409047 27898060 N/A N/A OmniPath
PPM1D CHEK1 15870257 27898060 inhibition N/A OmniPath
PPM1D CHEK2 16311512 16936775 20599567 27898060 inhibition,stimulant N/A OmniPath
PPM1D MDM2 17936559 17939684 27898060 inhibition,stimulant N/A OmniPath
PPM1D ATM 16949371 19360021 27898060 inhibition N/A OmniPath
PPM1D TP53 15870257 17936559 20093361 27898060 inhibition,stimulant N/A OmniPath
TP53 PPM1D 15870257 17936559 20093361 27898060 stimulant N/A OmniPath
PPM1D MAPK14 11101524 19713933 27898060 inhibition N/A OmniPath
E2F1 PPM1D 16912047 27898060 stimulant N/A OmniPath
PPM1D UNG 15327777 15870257 16189514 27898060 inhibition N/A OmniPath
PPM1D H2AX 20101220 20118229 20460517 27898060 inhibition N/A OmniPath
PPM1D RPS6KA3 15206906 27898060 N/A N/A OmniPath
PPM1D MAPK12 15870257 27898060 inhibition N/A OmniPath

Visualization










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