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GENE：PSEN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSEN2
FullNmae presenilin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9509
EnsembleID ENSG00000143801
Uniprot P49810

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSEN2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSEN2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSEN2 GO:0000139,GO:0000776,GO:0001666,GO:0004175,GO:0005515,GO:0005634,GO:0005637,GO:0005743,GO:0005765,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005813,GO:0005886,GO:0005886,GO:0005938,GO:0006509,GO:0006509,GO:0006816,GO:0007219,GO:0007220,GO:0007220,GO:0008021,GO:0009986,GO:0016020,GO:0016324,GO:0016485,GO:0030018,GO:0030426,GO:0031594,GO:0032991,GO:0034205,GO:0035253,GO:0035556,GO:0042500,GO:0042734,GO:0042987,GO:0042987,GO:0042987,GO:0043025,GO:0043066,GO:0043085,GO:0043198,GO:0045121,GO:0048471,GO:0050435,GO:0070765,GO:0110097,GO:1990456

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSEN2 hsa:5664 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
PSEN2 hsa:5664 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PSEN2 hsa:5664 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSEN2 hsa:5664 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRAF6 PSEN2 18996842 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 PSEN2 18996842 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSEN2 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
PSEN2 NOTCH1 15246694 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
APH1A PSEN2 20005715 interaction type N/A PSP,SignaLink
FLNB PSEN2 20005715 interaction type N/A PSP
NCSTN PSEN2 20005715 interaction type N/A PSP
NCSTN PSEN2 10993067 18988627 20005715 20005715 N/A N/A SignaLink
FLNB PSEN2 18988627 20005715 20005715 21071413 9437013 9437013 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PSEN2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PSEN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PSEN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PSEN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC PSEN2 12695333 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PSEN2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PSEN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PSEN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PSEN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PSEN2 14585504 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PSEN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PSEN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PSEN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A PSEN2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CSNK2A1 PSEN2 22135298 phosphorylation N/A PhosphoSite
AURKA PSEN2 22135298 phosphorylation N/A PhosphoSite
CSNK1D PSEN2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NOS3 PSEN2 25348397 N/A physical interaction ComPPI
IFIT3 PSEN2 25348397 N/A physical interaction ComPPI
ACTG1 PSEN2 25348397 N/A physical interaction ComPPI
TRAF6 PSEN2 25348397 N/A physical interaction ComPPI
BCL2L1 PSEN2 10446169 14525934 24234451 25348397 colocalization,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro ComPPI,HPRD,IntAct
CSNK1D PSEN2 14525934 25348397 8972483 9558331 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RNF115 PSEN2 25348397 N/A physical interaction ComPPI
NOTCH4 PSEN2 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOTCH1 PSEN2 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vivo ComPPI,HPRD
FHL2 PSEN2 11001931 14525934 24234451 25348397 27898060 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
FLNA PSEN2 14525934 24234451 25348397 9437013 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
CIB1 PSEN2 10366599 14525934 24234451 25348397 colocalization,physical association two hybrid,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CASP1 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP8 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vivo ComPPI,HPRD
CLK1 PSEN2 24234451 25348397 26496610 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK2A1 PSEN2 14525934 25348397 8972483 9558331 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
APBA2 PSEN2 25348397 N/A physical interaction ComPPI
EID1 PSEN2 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDCD4 PSEN2 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
SRI PSEN2 10748169 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,filter binding,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PSEN2 ICAM5 11719200 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PSEN2 FLNB 14525934 24234451 25348397 9437013 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PSEN2 KCNIP3 14525934 25348397 9771752 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PSEN2 UBQLN1 11076969 14525934 16813565 17614368 24234451 25348397 27898060 colocalization,physical association two hybrid,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PSEN2 NCSTN 10993067 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PSEN2 RAB11A 10369872 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
PSEN2 APH1A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PSEN2 APH1B 12297508 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSEN2 PSENEN 12198112 12639958 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSEN2 CTNND2 10037471 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSEN2 METTL2B 11738826 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PSEN2 DOCK3 10854253 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PSEN2 KCNIP4 11847232 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PSEN2 CAPN1 10677567 14525934 25348397 27898060 9852298 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PSEN2 CTNNB1 10037471 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSEN2 NOTCH2 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSEN2 NOTCH3 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSEN2 GFAP 25348397 N/A physical interaction ComPPI
PSEN2 APBA1 25348397 N/A physical interaction ComPPI
PSEN2 APBA3 25348397 N/A physical interaction ComPPI
PSEN2 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 ECSIT 21163940 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,confocal microscopy ComPPI,IntAct
PSEN2 MAST1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 RHEB 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 FBXL12 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 EXOC6 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 DNAJB1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 LIPF 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 RNF32 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 APP 10078972 14525934 24234451 25348397 9223340 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PSEN2 CEP55 25348397 N/A physical interaction ComPPI
PSEN2 ELAVL1 25348397 N/A physical interaction ComPPI
PSEN2 EVI5L 25348397 N/A physical interaction ComPPI
PSEN2 GCDH 25348397 N/A physical interaction ComPPI
PSEN2 IFIT5 25348397 N/A physical interaction ComPPI
PSEN2 OGA 25348397 N/A physical interaction ComPPI
PSEN2 SPC24 25348397 N/A physical interaction ComPPI
PSEN2 DYNC1H1 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PSEN2 AAMP 25348397 N/A physical interaction ComPPI
PSEN2 CHKA 25348397 N/A physical interaction ComPPI
PSEN2 ECD 25348397 N/A physical interaction ComPPI
PSEN2 HPS1 25348397 N/A physical interaction ComPPI
PSEN2 TSPAN5 25348397 N/A physical interaction ComPPI
PSEN2 DLK1 25348397 N/A physical interaction ComPPI
PSEN2 ART3 25348397 N/A physical interaction ComPPI
PSEN2 ERGIC3 25348397 N/A physical interaction ComPPI
PSEN2 FAF2 25348397 N/A physical interaction ComPPI
PSEN2 KIF22 25348397 N/A physical interaction ComPPI
PSEN2 PPP5C 25348397 N/A physical interaction ComPPI
PSEN2 NPLOC4 25348397 N/A physical interaction ComPPI
CFLAR PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CSNK1A1 PSEN2 14525934 8972483 N/A experimental interaction detection HPRD
PSEN2 HLA-DMB 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct
CASP1 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
CSNK1A1 PSEN2 20068231 27898060 8972483 N/A N/A OmniPath
CASP7 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
CASP3 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
PSEN2 APP 10078972 12011466 27898060 9223340 N/A N/A OmniPath
PSEN2 TRAF6 18996842 23707529 27898060 N/A N/A OmniPath
PSEN2 JAG2 12551931 27898060 N/A N/A OmniPath
CASP8 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
CSNK1D PSEN2 20068231 27898060 8972483 9558331 9990034 N/A N/A OmniPath
CASP6 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
MAPK1 PSEN2 27898060 8972483 N/A N/A OmniPath
PSEN2 NOTCH1 11518718 15246694 27898060 stimulant N/A OmniPath
CSNK2A1 PSEN2 20068231 27898060 8972483 9558331 9990034 N/A N/A OmniPath
NCSTN PSEN2 10993067 12297508 15474363 27898060 stimulant N/A OmniPath
APH1A PSEN2 12297508 12471034 15474363 27898060 stimulant N/A OmniPath
APH1B PSEN2 12297508 27898060 stimulant N/A OmniPath

Visualization










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