GENE：TRPM2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TRPM2 |
| FullNmae | transient receptor potential cation channel subfamily M member 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12339 |
| EnsembleID | ENSG00000142185 |
| Uniprot | O94759 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TRPM2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TRPM2 | GO:0001659,GO:0002407,GO:0005261,GO:0005262,GO:0005272,GO:0005384,GO:0005509,GO:0005509,GO:0005764,GO:0005765,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006816,GO:0009408,GO:0014074,GO:0015278,GO:0030659,GO:0032956,GO:0033194,GO:0035579,GO:0035584,GO:0035725,GO:0042995,GO:0043204,GO:0051209,GO:0051209,GO:0051209,GO:0051289,GO:0051489,GO:0070301,GO:0070588,GO:0070588,GO:0070821,GO:0071277,GO:0071415,GO:0071421,GO:0071502,GO:0071577,GO:0072571,GO:0097028,GO:0097553,GO:0098703,GO:0099604,GO:0099604,GO:0101003 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TRPM2 | hsa:7226 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| TRPM2 | hsa:7226 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | TRPM2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | TRPM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | TRPM2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP1R12A | TRPM2 | 24234451 25348397 28330616 | association | pull down | ComPPI,IntAct |
| HNRNPL | TRPM2 | 25348397 | N/A | physical interaction | ComPPI |
| TRPC6 | TRPM2 | 12032305 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| TRPM2 | ITPR3 | 11290752 14525934 | N/A | experimental interaction detection | HPRD |
| PTPN13 | TRPM2 | 17251321 27898060 | inhibition | N/A | OmniPath |
| EFHC1 | TRPM2 | 22226147 27898060 | stimulant | N/A | OmniPath |
| PRKCA | TRPM2 | 24337049 27898060 | stimulant | N/A | OmniPath |
| TP53 | TRPM2 | 18431400 27898060 | inhibition | N/A | OmniPath |