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GENE：GRK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GRK2
FullNmae G protein-coupled receptor kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:289
EnsembleID ENSG00000173020
Uniprot P25098

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GRK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GRK2 GO:0001664,GO:0002026,GO:0002029,GO:0002029,GO:0002029,GO:0003108,GO:0004672,GO:0004703,GO:0004703,GO:0004703,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0006468,GO:0007186,GO:0007186,GO:0007213,GO:0007217,GO:0007507,GO:0016020,GO:0016020,GO:0018105,GO:0019079,GO:0031623,GO:0031694,GO:0031755,GO:0033605,GO:0045988,GO:0046718,GO:0047696,GO:0060048,GO:0098793,GO:0098794,GO:1901081

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GRK2 hsa:156 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
GRK2 hsa:156 path:hsa04144 Endocytosis - Homo sapiens (human)
GRK2 hsa:156 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
GRK2 hsa:156 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GRK2 hsa:156 path:hsa04740 Olfactory transduction - Homo sapiens (human)
GRK2 hsa:156 path:hsa05032 Morphine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ROR2 GRK2 18848778 23331499 stimulation N/A SignaLink
GRK2 GNAI1 10508237 10644702 15337520 16183910 17084806 18538863 23109003 chemical activation reaction N/A SignaLink
GRK2 GNAI2 10508237 10644702 15337520 16183910 17084806 18538863 23109003 chemical activation reaction N/A SignaLink
GRK2 GNAI3 10508237 10644702 15337520 16183910 17084806 18538863 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AKAP12 GRK2 20005715 interaction type N/A PSP
ARRB1 GRK2 20005715 interaction type N/A PSP
CAV1 GRK2 20005715 interaction type N/A PSP
PDC GRK2 20005715 interaction type N/A PSP
RCVRN GRK2 20005715 interaction type N/A PSP
SNCA GRK2 20005715 interaction type N/A PSP
CAV1 GRK2 10085129 18988627 20005715 N/A N/A SignaLink
ARRB1 GRK2 20005715 20005715 N/A N/A SignaLink
AKAP12 GRK2 11309381 18988627 20005715 20005715 N/A N/A SignaLink
PDC GRK2 10884381 10884381 18988627 20005715 20005715 21071413 N/A N/A SignaLink
RCVRN GRK2 12507501 18988627 20005715 20005715 N/A N/A SignaLink
SNCA GRK2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 GRK2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 GRK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C GRK2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GRK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 GRK2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GRK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 GRK2 12423667 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 GRK2 12423667 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000018C928 GRK2 22473208 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000236310 GRK2 22473208 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000045147B GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 GRK2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015188E GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004D84DB GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 GRK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CC864 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000183BED GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002DD349 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000346991 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041E949 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237AF9 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000254A6 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000045DBD GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065FDF GRK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000CC005 GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E008F GRK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000007340 GRK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004AF715 GRK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000003ABC4 GRK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000192A75 GRK2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC GRK2 22135298 phosphorylation N/A PhosphoSite
CDK2 GRK2 22135298 phosphorylation N/A PhosphoSite
GRK2 RDX 22135298 phosphorylation N/A PhosphoSite
GRK2 OPRD1 22135298 phosphorylation N/A PhosphoSite
GRK2 EZR 22135298 phosphorylation N/A PhosphoSite
GRK2 ADRB2 22135298 phosphorylation N/A PhosphoSite
GRK2 SLC9A5 22135298 phosphorylation N/A PhosphoSite
GRK2 CHRM2 22135298 phosphorylation N/A PhosphoSite
GRK2 OPRM1 22135298 phosphorylation N/A PhosphoSite
GRK2 HRH1 22135298 phosphorylation N/A PhosphoSite
GRK2 CLTB 22135298 phosphorylation N/A PhosphoSite
GRK2 MAPK14 22135298 phosphorylation N/A PhosphoSite
GRK2 MSN 22135298 phosphorylation N/A PhosphoSite
GRK2 KCNIP3 22135298 phosphorylation N/A PhosphoSite
GRK2 ADIPOR1 22135298 phosphorylation N/A PhosphoSite
GRK2 SMAD2 22135298 phosphorylation N/A PhosphoSite
GRK2 IGF1R 22135298 phosphorylation N/A PhosphoSite
GRK2 SNCA 22135298 phosphorylation N/A PhosphoSite
PRKCA GRK2 22135298 phosphorylation N/A PhosphoSite
PRKCG GRK2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
DDX6 GRK2 25348397 N/A physical interaction ComPPI
PDE6G GRK2 12624098 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AGTR1 GRK2 25348397 N/A physical interaction,in vivo ComPPI
TUBB GRK2 24234451 24813628 25348397 27898060 phosphorylation reaction protein kinase assay ComPPI,IntAct,OmniPath
HSP90AB1 GRK2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKCA GRK2 11042191 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SRC GRK2 12624098 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCD GRK2 11042191 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3CG GRK2 12163475 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK3 GRK2 10574913 10727525 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TPM2 GRK2 14525934 16094730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
OPRD1 GRK2 11040053 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKACA GRK2 11278469 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PDC GRK2 10884381 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDGFRB GRK2 25348397 N/A physical interaction ComPPI
GNAQ GRK2 12885252 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBC GRK2 17006543 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
HSP90AA1 GRK2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GIT1 GRK2 14525934 18369319 24234451 25348397 9826657 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
PTPRF GRK2 25348397 N/A physical interaction ComPPI
CAV1 GRK2 10085129 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PEBP1 GRK2 14525934 14654844 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EPHA2 GRK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKCB GRK2 12456365 12679936 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NFKBIA GRK2 19008357 24234451 25348397 N/A anti bait coimmunoprecipitation,far western blotting,physical interaction ComPPI,IntAct
AKAP12 GRK2 11309381 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RHO GRK2 10722682 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRM1 GRK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PRKCG GRK2 11042191 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTR9 GRK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RCVRN GRK2 12507501 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARRB1 GRK2 14525934 25348397 8885248 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRK2 BDKRB2 11517230 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK2 CAPN2 12130691 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK2 FSHR 10379886 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRK2 FPR1 14525934 22447027 24234451 25348397 7836371 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
GRK2 MC4R 12639913 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRK2 SNCA 10617630 10852916 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRK2 RPLP2 12379128 14525934 14729942 14997482 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK2 NCS1 12351722 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRK2 PDCL 10884381 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRK2 CCR4 10754297 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRK2 GIT2 10896954 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
GRK2 CCR5 10085131 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRK2 MDM2 14525934 17006543 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
GRK2 EGFR 14525934 15620700 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,imaging technique,in vivo ComPPI,HPRD,IntAct
GRK2 EGF 14525934 15620700 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRK2 ADRA2A 14525934 25348397 7876239 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK2 GNA15 25348397 N/A physical interaction ComPPI
GRK2 EDNRB 25348397 N/A physical interaction ComPPI
GRK2 ADRB2 25348397 N/A physical interaction ComPPI
GRK2 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GRK2 HDAC6 22193721 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
GRK2 GNB1 25348397 N/A physical interaction ComPPI
GRK2 KCNIP3 25348397 N/A physical interaction ComPPI
GRK2 FBXO25 25348397 N/A physical interaction ComPPI
GRK2 RASGRF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GRK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
GRK2 GRK3 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GRK2 ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GRK2 MOV10 25348397 N/A physical interaction ComPPI
GRK2 DNAAF5 25348397 N/A physical interaction ComPPI
GRK2 FERMT2 25348397 N/A physical interaction ComPPI
GRK2 PAPOLA 25348397 N/A physical interaction ComPPI
GRK2 PPWD1 25348397 N/A physical interaction ComPPI
GRK2 PLPBP 25348397 N/A physical interaction ComPPI
GRK2 NARS2 25348397 N/A physical interaction ComPPI
GRK2 RXRB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRK2 PRPF4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRK2 SLAIN2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRK2 GNB2 25348397 N/A physical interaction ComPPI
GRK2 GPR17 25348397 N/A physical interaction ComPPI
GRK2 PPP1R16B 25348397 N/A physical interaction ComPPI
GRK2 TBC1D14 25348397 N/A physical interaction ComPPI
GRK2 PTCH1 19502428 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRK2 CDC37 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SRC GRK2 11278940 11566877 12624098 16725308 27898060 stimulant N/A OmniPath
PRKACA GRK2 11278469 27898060 N/A N/A OmniPath
PRKCA GRK2 10727525 11042191 11278469 27898060 9013639 inhibition,stimulant N/A OmniPath
GRK2 VCP 16027165 16140914 27898060 N/A N/A OmniPath
GRK2 CASR 12409307 27898060 9694886 N/A N/A OmniPath
GRK2 OPRM1 10488100 11861651 12123746 21292762 22375000 27898060 inhibition,stimulant N/A OmniPath
PRKCD GRK2 11042191 27898060 stimulant N/A OmniPath
GRK2 PDGFRB 15271984 27898060 N/A N/A OmniPath
MDM2 GRK2 17006543 21081496 26228571 27898060 N/A N/A OmniPath
CDK2 GRK2 20080565 27898060 inhibition N/A OmniPath
PRKCG GRK2 11042191 27898060 stimulant N/A OmniPath
CAPN2 GRK2 12130691 27898060 N/A N/A OmniPath
GRK2 SMO 15618519 21695114 23074268 27898060 stimulant N/A OmniPath
MAPK3 GRK2 10574913 10727525 18088087 18767875 19651622 27898060 inhibition,stimulant N/A OmniPath
GRK2 MAPK14 17055984 27898060 inhibition N/A OmniPath
GRK2 EZR 15843435 27898060 stimulant N/A OmniPath
GRK2 BDKRB2 11517230 27898060 inhibition N/A OmniPath
GRK2 CFL2 27898060 9677407 N/A N/A OmniPath
GRK2 NDRG1 15461589 27898060 N/A N/A OmniPath
GRK2 RPTOR 19864431 27898060 N/A N/A OmniPath
ROR2 GRK2 18848778 27898060 stimulant N/A OmniPath
GRK2 SNCA 10617630 10852916 27898060 inhibition N/A OmniPath
GRK2 CCR5 10085131 27898060 stimulant N/A OmniPath
GRK2 ADRB2 10499588 11309381 14654844 18801735 23473322 27898060 8662852 stimulant N/A OmniPath
GRK2 KCNIP3 17102134 27898060 N/A N/A OmniPath
GRK2 TBXA2R 16956790 27898060 inhibition N/A OmniPath
GRK2 MC4R 12639913 27898060 inhibition N/A OmniPath
GRK2 C5AR1 27898060 7642584 N/A N/A OmniPath
GRK2 OPRD1 10893226 11040053 16135360 17322005 18395423 19344370 27898060 inhibition N/A OmniPath
GRK2 DRD1 11773080 27898060 N/A N/A OmniPath
GRK2 ADRA2A 19651622 27898060 7876239 N/A N/A OmniPath
GRK2 CHRM2 27898060 8119296 9162044 inhibition N/A OmniPath
GRK2 CLTB 22704991 27898060 N/A N/A OmniPath
GRK2 PDE6G 11502744 12624098 27898060 stimulant N/A OmniPath
GRK2 HRH1 15107581 27898060 N/A N/A OmniPath
GRK2 RPLP2 12379128 14729942 14997482 16565220 18212344 18452278 18669648 18691976 19691289 20068231 20166139 20230923 27898060 stimulant N/A OmniPath
GRK2 ICAM3 11784723 27898060 N/A N/A OmniPath
GRK2 TUBB3 12631274 27898060 8619990 N/A N/A OmniPath
GRK2 FPR1 22447027 27898060 7836371 N/A N/A OmniPath
GRK2 SAT1 27898060 8954982 N/A N/A OmniPath

Visualization










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