GeneInfo:
GeneAttribute |
GeneDescription |
GeneSymbol |
DKK3 |
FullNmae |
dickkopf WNT signaling pathway inhibitor 3 |
LocusType |
gene with protein product |
Status |
Approved |
HGNC_id |
HGNC:2893 |
EnsembleID |
ENSG00000050165 |
Uniprot |
Q9UBP4 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol |
CellDeathType |
PMID |
Description |
GeneType |
DKK3 |
immunogenic |
38538696 |
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) |
retulator signature |
Go Annotation:
GeneSymbol |
Go id |
DKK3 |
GO:0005515,GO:0005615,GO:0009653,GO:0016055,GO:0017015,GO:0030325,GO:0032348,GO:0039706,GO:0045892,GO:0048019,GO:0090090,GO:0090090,GO:1902613,GO:2000065 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source |
Target |
Pmid |
Interactiontype |
Methods |
Database |
AR |
DKK3 |
20610535
|
trascriptional regulation,stimulation |
chromatin immunoprecipitation array |
TFlink |
E2F4 |
DKK3 |
17531812
|
trascriptional regulation,stimulation |
chromatin immunoprecipitation array |
TFlink |
SMARCA4 |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
CEBPA |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
CTCF |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
EGR1 |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
FOXA1 |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
FOS |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
GATA2 |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
HNF4A |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
TRIM28 |
DKK3 |
18971253
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
MYCN |
DKK3 |
18059033
21796614
|
trascriptional regulation,stimulation |
inferred by curator |
TFlink |
Source |
Target |
Pmid |
Interactiontype |
Methods |
Database |
URS0000345DEB |
DKK3 |
23538390
25416803
|
mrna cleavage,inhibition |
western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay |
TarBase |
URS00001A7F58 |
DKK3 |
24325785
25416803
|
mrna cleavage,inhibition |
western blot,miRNA interference luciferase reporter assay |
TarBase |
URS00000D0BB4 |
DKK3 |
20371350
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS00003804D8 |
DKK3 |
20371350
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS00005194EC |
DKK3 |
19536157
20371350
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS000012930C |
DKK3 |
20371350
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS00000E7139 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS0000077DDE |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS000075BDA4 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS0000070B1D |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS00002F0130 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS0000160683 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS0000136174 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS0000366551 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS000000E601 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS0000272039 |
DKK3 |
19536157
25416803
|
mrna cleavage,inhibition |
clip |
TarBase |
URS00000B0E50 |
DKK3 |
25416803
26468775
|
mrna cleavage,inhibition |
western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay,miRNA interference luciferase reporter assay |
TarBase |
Source |
Target |
Pmid |
Interactiontype |
Methods |
Database |
GOLGA2 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
ATP5PO |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
SGTA |
DKK3 |
24234451
25348397
|
physical association |
two hybrid,two hybrid array,two hybrid prey pooling approach |
ComPPI,IntAct |
SMAD4 |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,physical interaction,two hybrid array |
ComPPI,IntAct |
SLC25A6 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
FZR1 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
GSK3B |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
UBA52 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
APC |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,physical interaction,two hybrid array |
ComPPI,IntAct |
CDH1 |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,two hybrid array |
ComPPI,IntAct |
SREBF2 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
TIMP3 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
TNIP2 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
AURKA |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,physical interaction,two hybrid array |
ComPPI,IntAct |
ADAMTS1 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
LAMA5 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
GORASP1 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
STX5 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
ESR2 |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,physical interaction,two hybrid array |
ComPPI,IntAct |
ASPM |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
MYO5B |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
GOSR2 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
PPM1D |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,physical interaction,two hybrid array |
ComPPI,IntAct |
BCAR3 |
DKK3 |
24234451
25348397
25640309
|
physical association |
two hybrid,physical interaction,two hybrid array |
ComPPI,IntAct |
HSPD1 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
SLC25A5 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
GLG1 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
RPS3 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
ATP5PD |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
GDF11 |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
INHBE |
DKK3 |
25348397
|
N/A |
physical interaction |
ComPPI |
DKK3 |
CEP131 |
25348397
|
N/A |
physical interaction |
ComPPI |
DKK3 |
MYO5A |
25348397
|
N/A |
physical interaction |
ComPPI |
DKK3 |
ATP5PB |
25348397
|
N/A |
physical interaction |
ComPPI |
DKK3 |
MT-ATP8 |
25348397
|
N/A |
physical interaction |
ComPPI |
DKK3 |
PCM1 |
25348397
|
N/A |
physical interaction |
ComPPI |
Visualization