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GENE：ASAH1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ASAH1
FullNmae N-acylsphingosine amidohydrolase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:735
EnsembleID ENSG00000104763
Uniprot Q13510

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ASAH1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
ASAH1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ASAH1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ASAH1 GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0006631,GO:0016811,GO:0017040,GO:0017040,GO:0017040,GO:0017064,GO:0030216,GO:0043202,GO:0046512,GO:0046512,GO:0046513,GO:0046514,GO:0046514,GO:0050810,GO:0062098,GO:0070062,GO:0071356,GO:0102121,GO:1904724,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ASAH1 hsa:427 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
ASAH1 hsa:427 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ASAH1 hsa:427 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
ASAH1 hsa:427 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SRPK1 ASAH1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 ASAH1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ASAH1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ASAH1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ASAH1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ASAH1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ASAH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF6 ASAH1 16500425 trascriptional regulation,stimulation inferred by curator TFlink
MYC ASAH1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ASAH1 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
SMPD1 ASAH1 25361965 interaction type N/A PTMCode2
ASAH1 SMPD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TBC1D22B ASAH1 25348397 N/A physical interaction ComPPI
FTH1 ASAH1 25348397 N/A physical interaction ComPPI
SETDB1 ASAH1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NONO ASAH1 25348397 N/A physical interaction ComPPI
ZIC1 ASAH1 25348397 N/A physical interaction ComPPI
PSMA3 ASAH1 25348397 N/A physical interaction ComPPI
SRPK1 ASAH1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
AIRE ASAH1 25348397 N/A physical interaction ComPPI
CAMK2B ASAH1 25348397 N/A physical interaction ComPPI
NCDN ASAH1 25348397 N/A physical interaction ComPPI
TSC22D1 ASAH1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NSG2 ASAH1 25348397 N/A physical interaction ComPPI
NEFH ASAH1 25348397 N/A physical interaction ComPPI
CAMK1D ASAH1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
A2M ASAH1 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
PNKD ASAH1 25348397 N/A physical interaction ComPPI
HTATIP2 ASAH1 25348397 N/A physical interaction ComPPI
HSF2 ASAH1 25348397 N/A physical interaction ComPPI
CYP1A2 ASAH1 25348397 N/A physical interaction ComPPI
AAMP ASAH1 25348397 N/A physical interaction ComPPI
AAGAB ASAH1 25348397 N/A physical interaction ComPPI
FBXO6 ASAH1 25348397 N/A physical interaction ComPPI
HERC2 ASAH1 25348397 N/A physical interaction ComPPI
HERC2P3 ASAH1 25348397 N/A physical interaction ComPPI
HSPB2 ASAH1 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
ASAH1 GSG1 25348397 N/A physical interaction ComPPI
ASAH1 GLT1D1 25348397 N/A physical interaction ComPPI
ASAH1 SLCO6A1 25348397 N/A physical interaction ComPPI
ASAH1 RNF6 25348397 N/A physical interaction ComPPI
ASAH1 TRMT2A 25348397 N/A physical interaction ComPPI
ASAH1 ZNF684 25348397 N/A physical interaction ComPPI
ASAH1 ZNF556 25348397 N/A physical interaction ComPPI
ASAH1 LYPD1 25348397 N/A physical interaction ComPPI
ASAH1 SMPD1 12815059 14525934 N/A experimental interaction detection HPRD

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