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GENE：ARAF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ARAF
FullNmae A-Raf proto-oncogene, serine/threonine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:646
EnsembleID ENSG00000078061
Uniprot P10398

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ARAF necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ARAF immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ARAF GO:0000165,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005575,GO:0005739,GO:0005829,GO:0005829,GO:0016310,GO:0032006,GO:0032434,GO:0033138,GO:0036211,GO:0043066,GO:0046872,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ARAF hsa:369 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
ARAF hsa:369 path:hsa01522 Endocrine resistance - Homo sapiens (human)
ARAF hsa:369 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
ARAF hsa:369 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
ARAF hsa:369 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
ARAF hsa:369 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ARAF hsa:369 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
ARAF hsa:369 path:hsa04720 Long-term potentiation - Homo sapiens (human)
ARAF hsa:369 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
ARAF hsa:369 path:hsa04730 Long-term depression - Homo sapiens (human)
ARAF hsa:369 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ARAF hsa:369 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
ARAF hsa:369 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
ARAF hsa:369 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
ARAF hsa:369 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ARAF hsa:369 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ARAF hsa:369 path:hsa05034 Alcoholism - Homo sapiens (human)
ARAF hsa:369 path:hsa05160 Hepatitis C - Homo sapiens (human)
ARAF hsa:369 path:hsa05161 Hepatitis B - Homo sapiens (human)
ARAF hsa:369 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
ARAF hsa:369 path:hsa05210 Colorectal cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
ARAF hsa:369 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05213 Endometrial cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05214 Glioma - Homo sapiens (human)
ARAF hsa:369 path:hsa05215 Prostate cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05218 Melanoma - Homo sapiens (human)
ARAF hsa:369 path:hsa05219 Bladder cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
ARAF hsa:369 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
ARAF hsa:369 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05224 Breast cancer - Homo sapiens (human)
ARAF hsa:369 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
ARAF hsa:369 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS ARAF 10545207 23180781 physical association two hybrid InnateDB
IRAK2 ARAF 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 ARAF 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TIRAP ARAF 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ARAF KRAS 23180781 25416956 physical association two hybrid InnateDB
ARAF AGTRAP 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
COPS3 ARAF 20005715 interaction type N/A PSP
PIK3R1 ARAF 20005715 interaction type N/A PSP
YWHAG ARAF 20005715 interaction type N/A PSP
YWHAH ARAF 20005715 interaction type N/A PSP
PIK3R1 ARAF 11812000 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 ARAF 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ARAF 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 ARAF 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ARAF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ARAF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ARAF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ARAF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ARAF 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001597DC ARAF 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SRC ARAF 22135298 phosphorylation N/A PhosphoSite
ARAF BAD 22135298 phosphorylation N/A PhosphoSite
ARAF SLC9A3R2 22135298 phosphorylation N/A PhosphoSite
ARAF MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HRAS ARAF 25361965 interaction type N/A PTMCode2
ARAF HRAS 25361965 interaction type N/A PTMCode2
BRAF ARAF 25361965 interaction type N/A PTMCode2
ARAF BRAF 25361965 interaction type N/A PTMCode2
RRAS2 ARAF 25361965 interaction type N/A PTMCode2
ARAF RRAS2 25361965 interaction type N/A PTMCode2
MAP2K1 ARAF 25361965 interaction type N/A PTMCode2
YWHAB ARAF 25361965 interaction type N/A PTMCode2
ARAF YWHAB 25361965 interaction type N/A PTMCode2
RRAS ARAF 25361965 interaction type N/A PTMCode2
ARAF RRAS 25361965 interaction type N/A PTMCode2
YWHAH ARAF 25361965 interaction type N/A PTMCode2
ARAF YWHAH 25361965 interaction type N/A PTMCode2
NELFCD ARAF 25361965 interaction type N/A PTMCode2
ARAF NELFCD 25361965 interaction type N/A PTMCode2
PIK3R1 ARAF 25361965 interaction type N/A PTMCode2
ARAF PIK3R1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRAS ARAF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP5F1B ARAF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DPM1 ARAF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EMD ARAF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RABGGTB ARAF 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
E2F6 ARAF 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
YWHAG ARAF 14525934 15324660 17353931 24234451 25348397 25852190 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CCDC22 ARAF 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AB1 ARAF 22939624 24234451 25036637 25348397 association,physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
HIPK4 ARAF 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BAD ARAF 25348397 N/A physical interaction ComPPI
CBY1 ARAF 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HRAS ARAF 12620389 14525934 24234451 24441586 25348397 physical association two hybrid,isothermal titration calorimetry,nuclear magnetic resonance,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIK3R1 ARAF 10967104 11812000 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,phage display,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RRAS ARAF 10848612 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
ARAF MAP2K1 14525934 17979178 24234451 24746704 25348397 26496610 7731720 8157000 8394352 8621729 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
ARAF RRAS2 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ARAF EFEMP1 12620389 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARAF COPS3 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ARAF PRPF6 10848612 12620389 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ARAF NELFCD 12620389 21988832 24234451 25348397 physical association two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
ARAF PBK 12620389 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
ARAF CSNK2B 10094392 14525934 24234451 25348397 9042965 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ARAF KLHL12 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ARAF PDGFRB 14525934 15763428 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ARAF RGS12 14525934 17380122 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ARAF SFN 15778465 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
ARAF YWHAH 17979178 24234451 25348397 25852190 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
ARAF YWHAE 20936779 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ARAF YWHAZ 19933840 20052757 20936779 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,peptide array,physical interaction,two hybrid pooling approach ComPPI,IntAct
ARAF CHD6 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ARAF MYO18A 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ARAF IRAK2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF IRF7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF TIRAP 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF HSP90AA1 25348397 N/A physical interaction ComPPI
ARAF HSP90AA2P 25348397 N/A physical interaction ComPPI
ARAF BRAF 17979178 20130576 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification,proximity ligation assay ComPPI,IntAct
ARAF MLH1 20706999 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARAF DIDO1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ARAF TESK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ARAF WNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ARAF CPS1 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ARAF FBXO6 25348397 N/A physical interaction ComPPI
ARAF YWHAB 24234451 24255178 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF GNA12 25348397 N/A physical interaction ComPPI
ARAF CDC37 24189400 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
ARAF FKBP5 24234451 25036637 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF AGTRAP 25348397 N/A physical interaction ComPPI
ARAF RNF2 25348397 N/A physical interaction ComPPI
ARAF ACTA2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF AIFM1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF BAG2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF YBX3 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF CTNNA1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF DDX5 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF DNAJA1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF DNAJA2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF EEF2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF TECR 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF HSP90B1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF HSPB1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF KIFBP 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF LRRC59 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF P4HB 25348397 N/A physical interaction ComPPI
ARAF PPP6C 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF RCN1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF RCN2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF RPL37 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF RPL39 25348397 N/A physical interaction ComPPI
ARAF SDF4 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF SLC25A1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF SLC25A13 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF SLC25A22 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF STUB1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF TIMM50 12620389 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
ARAF TRIM28 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF TUBA4A 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF TUBB6 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF ATP5MK 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF HERC2 25348397 N/A physical interaction ComPPI
ARAF HERC2P3 25348397 N/A physical interaction ComPPI
ARAF XPO1 25348397 N/A physical interaction ComPPI
ARAF JAK3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF UBXN6 25348397 N/A physical interaction ComPPI
ARAF FAF2 25348397 N/A physical interaction ComPPI
ARAF P4HA2 25348397 N/A physical interaction ComPPI
ARAF RAB3IP 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ARAF RAF1 20130576 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ARAF RPL39P5 24234451 25348397 25852190 association anti tag coimmunoprecipitation ComPPI,IntAct
ARAF TUBA1A 24234451 25348397 29568061 association pull down ComPPI,IntAct
MAP2K2 ARAF 11909642 14525934 21988832 24234451 24746704 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
PKM ARAF 12620389 14525934 24234451 25241761 25348397 physical association two hybrid,physical interaction,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
YWHAQ ARAF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCP1 ARAF 25348397 N/A physical interaction ComPPI
ASS1 ARAF 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TIMM44 ARAF 10848612 12620389 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
NUDT14 ARAF 12620389 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
CALU ARAF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF ARAF 1262038 14525934 N/A two hybrid HPRD
TCOF1 ARAF 24234451 30021884 physical association cross-linking study IntAct
SRC ARAF 27898060 9020159 stimulant N/A OmniPath
ARAF SLC9A3R2 26251448 26310448 27898060 N/A N/A OmniPath
HRAS ARAF 10545207 12620389 21779497 24441586 27898060 stimulant N/A OmniPath
ARAF MAP2K1 17979178 18039929 24114843 26496610 27898060 7731720 8157000 8394352 8621729 stimulant N/A OmniPath
ARAF MAP2K2 11909642 18039929 21779497 21988832 25852190 27898060 stimulant N/A OmniPath
ARAF MAPK3 18039929 27898060 stimulant N/A OmniPath
CDK7 ARAF 15710605 27898060 N/A N/A OmniPath
NRAS ARAF 21779497 27898060 stimulant N/A OmniPath
IRF7 ARAF 21903422 27898060 N/A N/A OmniPath
ARAF MAPK1 18039929 27898060 stimulant N/A OmniPath
PAK1 ARAF 15710605 27898060 stimulant N/A OmniPath
TIRAP ARAF 21903422 27898060 N/A N/A OmniPath

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