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GENE：CARD11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CARD11
FullNmae caspase recruitment domain family member 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16393
EnsembleID ENSG00000198286
Uniprot Q9BXL7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CARD11 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CARD11 GO:0001772,GO:0004385,GO:0005515,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0007249,GO:0030183,GO:0030890,GO:0031295,GO:0032449,GO:0032743,GO:0035739,GO:0038202,GO:0042100,GO:0042981,GO:0043123,GO:0043123,GO:0043123,GO:0043621,GO:0045061,GO:0045121,GO:0045577,GO:0045580,GO:0046037,GO:0046710,GO:0048872,GO:0050700,GO:0050700,GO:0050862,GO:0050862,GO:0051092,GO:0051092,GO:0051260,GO:0070062,GO:2000563

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CARD11 hsa:84433 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
CARD11 hsa:84433 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CARD11 hsa:84433 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL10 CARD11 11090634 11280761 11356195 11460167 12356734 14660645 14695475 15122200 15125833 15520247 16356855 16356856 16809782 16818229 17052756 17301840 17363905 17428801 17462996 17468049 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 23109003 24243840 24560716 24699077 24958845 26192618 29145629 interaction type,physical association,chemical activation reaction inferred by curator ACSN,Reactome,SignaLink
CARD11 MALT1 11090634 11280761 11356195 11460167 12356734 14660645 14695475 15125833 16356855 16809782 16818229 17052756 17301840 17363905 17428801 17462996 17948050 18264101 18264787 20685844 21133840 21199863 21232017 21873235 24243840 24560716 24699077 24958845 26192618 29145629 interaction type,physical association inferred by curator ACSN,Reactome
PRKCQ CARD11 10652356 15125833 15214048 15520247 15536066 16356856 16606694 17544292 17548359 18784374 19201850 23077238 23109003 23433459 23474202 23886063 25960930 26192618 interaction type,chemical activation reaction N/A ACSN,SignaLink
CARD11 IKBKG 11280761 11356195 11460167 12356734 14660645 16301747 16356855 16809782 16818229 17052756 17301840 17363905 17462996 17948050 18223652 18264101 18264787 19909372 20685844 21133840 21199863 21232017 21873235 23109003 24560716 24699077 24958845 26192618 29145629 interaction type,physical association,chemical activation reaction inferred by curator ACSN,Reactome,SignaLink
TRAF6 CARD11 11274345 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412 26192618 interaction type N/A ACSN
CARD11 BCL10 12154360 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD11 TRAF6 18625728 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD11 CASP8 18625728 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD11 GPS1 19444310 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD11 COPS5 19444310 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD11 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
CARD11 CARD11 15541657 16356855 17428801 24243840 29145629 physical association inferred by curator Reactome
MAP3K7 CARD11 10702308 10838074 10882101 11460167 14695475 15125833 15327770 16056267 16186825 16301747 16356855 17158449 17496917 19909372 20449947 29145629 physical association inferred by curator Reactome
IKBKB CARD11 16301747 16356855 19909372 29145629 physical association inferred by curator Reactome
CHUK CARD11 16301747 16356855 19909372 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
BCL10 CARD11 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR CARD11 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CARD11 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CARD11 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CARD11 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CARD11 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 CARD11 20584899 23807165 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS000007A060 CARD11 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000050CCE0 CARD11 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039607D CARD11 25416803 26206083 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CAMK2A CARD11 22135298 phosphorylation N/A PhosphoSite
PRKCQ CARD11 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP4K1 CARD11 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 CARD11 22135298 phosphorylation N/A PhosphoSite
CBLB CARD11 25361965 interaction type N/A PTMCode2
CARD11 CBLB 25361965 interaction type N/A PTMCode2
CARD11 PRKCQ 25361965 interaction type N/A PTMCode2
ZAP70 CARD11 25361965 interaction type N/A PTMCode2
CARD11 ZAP70 25361965 interaction type N/A PTMCode2
BCL10 CARD11 25361965 interaction type N/A PTMCode2
CARD11 BCL10 25361965 interaction type N/A PTMCode2
IKBKG CARD11 25361965 interaction type N/A PTMCode2
CARD11 IKBKG 25361965 interaction type N/A PTMCode2
MALT1 CARD11 25361965 interaction type N/A PTMCode2
CARD11 MALT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CCND1 CARD11 25348397 N/A physical interaction ComPPI
PPP2R1A CARD11 25348397 N/A physical interaction ComPPI
TRAF6 CARD11 25348397 N/A physical interaction ComPPI
TAB3 CARD11 25348397 N/A physical interaction ComPPI
PRKCQ CARD11 14525934 14673152 22528498 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CBLB CARD11 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
PRKCD CARD11 22528498 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy,tandem affinity purification ComPPI,IntAct
MAP4K1 CARD11 19706536 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS5 CARD11 19444310 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZAP70 CARD11 12154360 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBB CARD11 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
UBC CARD11 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A CARD11 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 CARD11 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
PDPK1 CARD11 14525934 15802604 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CASP8 CARD11 25348397 N/A physical interaction ComPPI
PRKCB CARD11 14525934 16356855 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PPP2CA CARD11 25348397 N/A physical interaction ComPPI
FYB1 CARD11 25348397 N/A physical interaction ComPPI
DPP4 CARD11 25348397 N/A physical interaction ComPPI
CHUK CARD11 25348397 N/A physical interaction ComPPI
GPS1 CARD11 19444310 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K7 CARD11 14525934 16301747 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
WDR1 CARD11 14525934 17293856 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
BCL10 CARD11 11278692 11356195 14525934 17948050 19118383 19444310 19815501 21157432 22528498 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SRPK2 CARD11 25348397 N/A physical interaction ComPPI
AKT1 CARD11 24234451 24548923 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
STUB1 CARD11 25348397 N/A physical interaction ComPPI
CARD11 SH2D3C 14525934 16825666 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CARD11 TAB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CARD11 IKBKG 14525934 16301747 17363905 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
CARD11 MALT1 17948050 22528498 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CARD11 USP2 25348397 N/A physical interaction ComPPI
CARD11 RNF181 25348397 N/A physical interaction ComPPI
CARD11 CSNK1A1 19118383 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CARD11 USP18 25348397 N/A physical interaction ComPPI
CARD11 RNF31 25348397 N/A physical interaction ComPPI
CSNK1A1 CARD11 19118383 27898060 N/A N/A OmniPath
CARD11 BCL10 11278692 11356195 12154360 12356734 15699074 16356855 18625728 18806265 19118383 19444310 19815501 21157432 21513986 23690623 25548215 27898060 stimulant N/A OmniPath
CARD11 MALT1 17948050 19118383 20685844 23322406 25748427 27898060 stimulant N/A OmniPath
TRAF6 CARD11 18625728 27898060 N/A N/A OmniPath
PDPK1 CARD11 15802604 21900206 27898060 stimulant N/A OmniPath
PRKCQ CARD11 14673152 16356855 16356856 19118383 20164171 21157432 24548923 27898060 stimulant N/A OmniPath
CARD11 CASP8 18625728 27898060 N/A N/A OmniPath
PPP2CA CARD11 21157432 27898060 inhibition N/A OmniPath
CAMK2A CARD11 16809782 27898060 N/A N/A OmniPath
MAP4K1 CARD11 19706536 27898060 N/A N/A OmniPath
PPP2CB CARD11 21157432 27898060 inhibition N/A OmniPath

Visualization










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