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GENE：EXOSC6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EXOSC6
FullNmae exosome component 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19055
EnsembleID ENSG00000223496
Uniprot Q5RKV6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EXOSC6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EXOSC6 GO:0000176,GO:0000176,GO:0000177,GO:0000177,GO:0000178,GO:0000178,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005730,GO:0005829,GO:0005829,GO:0006364,GO:0006396,GO:0006401,GO:0016075,GO:0034427,GO:0034475,GO:0045006,GO:0045190,GO:0045830,GO:0071028,GO:0071051,GO:0101019

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EXOSC6 hsa:118460 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 EXOSC6 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 EXOSC6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 EXOSC6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EXOSC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EXOSC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EXOSC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EXOSC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000045B99E EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000013DD8 EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 EXOSC6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC EXOSC6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 EXOSC6 19536157 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA EXOSC6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 EXOSC6 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EXOSC9 EXOSC6 25361965 interaction type N/A PTMCode2
EXOSC6 EXOSC9 25361965 interaction type N/A PTMCode2
EXOSC5 EXOSC6 25361965 interaction type N/A PTMCode2
EXOSC6 EXOSC5 25361965 interaction type N/A PTMCode2
LSM8 EXOSC6 25361965 interaction type N/A PTMCode2
EXOSC6 LSM8 25361965 interaction type N/A PTMCode2
ZFP36 EXOSC6 25361965 interaction type N/A PTMCode2
EXOSC6 ZFP36 25361965 interaction type N/A PTMCode2
EXOSC2 EXOSC6 25361965 interaction type N/A PTMCode2
EXOSC6 EXOSC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOSC5 EXOSC6 11719186 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
NUDT21 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SNW1 EXOSC6 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
LSM1 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC1 EXOSC6 24234451 25043052 25348397 26496610 association,physical association anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
TUFM EXOSC6 25348397 N/A physical interaction ComPPI
EXOSC8 EXOSC6 11719186 12419256 14525934 15231747 18631361 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
LSM7 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
JUN EXOSC6 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA3 EXOSC6 25348397 N/A physical interaction ComPPI
CUL3 EXOSC6 25348397 N/A physical interaction ComPPI
LSM8 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PSMA1 EXOSC6 25348397 N/A physical interaction ComPPI
PSMA6 EXOSC6 25348397 N/A physical interaction ComPPI
PSMA5 EXOSC6 25348397 N/A physical interaction ComPPI
DCP1B EXOSC6 25348397 N/A two hybrid,physical interaction ComPPI
ZFP36 EXOSC6 25348397 N/A two hybrid,physical interaction ComPPI
C1QBP EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CFTR EXOSC6 25348397 N/A physical interaction ComPPI
CHPF EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
UPF2 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC10 EXOSC6 14525934 15231747 21255825 24234451 25348397 association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MDM2 EXOSC6 25348397 N/A physical interaction ComPPI
MTREX EXOSC6 11719186 14525934 15231747 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
EIF3I EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RAB3GAP2 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 EXOSC2 11719186 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
EXOSC6 SRSF3 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 DIS3 11719186 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EXOSC6 ESRRA 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 EXOSC9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,two hybrid,physical interaction,in vivo ComPPI,IntAct
EXOSC6 EXOSC7 11719186 12419256 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
EXOSC6 NDUFA13 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 PALS2 11719186 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EXOSC6 MOCS3 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 DNAJC30 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 MIF4GD 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 GSE1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 EXOSC4 11719186 14525934 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EXOSC6 XRN1 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC6 HDGF 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EXOSC6 ELAVL1 25348397 N/A physical interaction ComPPI
EXOSC6 DIS3L 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC6 EXOSC3 20531389 21255825 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC6 AICDA 21255825 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC6 MAN2C1 25348397 N/A physical interaction ComPPI
EXOSC6 MRPS18B 25348397 N/A physical interaction ComPPI
EXOSC6 CEP250 25348397 N/A physical interaction ComPPI
EXOSC6 OBSL1 25348397 N/A physical interaction ComPPI
EXOSC6 MPHOSPH6 25348397 N/A physical interaction ComPPI
EXOSC6 PSMA2 25348397 N/A physical interaction ComPPI
EXOSC6 IFI16 25348397 N/A physical interaction ComPPI
EXOSC6 RBM7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC6 HBS1L 25348397 N/A physical interaction ComPPI
EXOSC6 DUSP13 25348397 N/A physical interaction ComPPI
EXOSC6 DUSP13 25348397 N/A physical interaction ComPPI
EXOSC6 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EXOSC6 FOXA1 25348397 N/A physical interaction ComPPI
EXOSC6 MNDA 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
C1D EXOSC6 25348397 N/A physical interaction ComPPI
PSMB1 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MRPL4 EXOSC6 25348397 N/A physical interaction ComPPI
EXOSC6 EXOSC6 14525934 15231747 N/A two hybrid HPRD

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