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GENE：GADD45G

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GADD45G
FullNmae growth arrest and DNA damage inducible gamma
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4097
EnsembleID ENSG00000130222
Uniprot O95257

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GADD45G mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GADD45G immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GADD45G ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GADD45G GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0006915,GO:0030154,GO:0043065,GO:0046330,GO:0051726,GO:0120162,GO:1900745

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GADD45G hsa:10912 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
GADD45G hsa:10912 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
GADD45G hsa:10912 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
GADD45G hsa:10912 path:hsa04110 Cell cycle - Homo sapiens (human)
GADD45G hsa:10912 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
GADD45G hsa:10912 path:hsa04210 Apoptosis - Homo sapiens (human)
GADD45G hsa:10912 path:hsa04218 Cellular senescence - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05200 Pathways in cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05210 Colorectal cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05213 Endometrial cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05214 Glioma - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05216 Thyroid cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05218 Melanoma - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05224 Breast cancer - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
GADD45G hsa:10912 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GADD45G MAP3K4 11371360 23180781 24104473 26192618 9827804 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IKBKG GADD45G 20098747 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
GADD45G ESR1 20005715 interaction type N/A PSP
GADD45G RARA 20005715 interaction type N/A PSP
GADD45G PCNA 20005715 interaction type N/A PSP
GADD45G RXRA 20005715 interaction type N/A PSP
GADD45G PPARG 20005715 interaction type N/A PSP
GADD45G RAN 20005715 interaction type N/A PSP
GADD45G PPARD 20005715 interaction type N/A PSP
GADD45G PTPRK 20005715 interaction type N/A PSP
GADD45G PIAS4 20005715 interaction type N/A PSP
GADD45G KAT5 20005715 interaction type N/A PSP
GADD45G MAP3K4 20005715 interaction type N/A PSP
GADD45G ESR1 10872826 18988627 20005715 20005715 N/A N/A SignaLink
GADD45G MAP3K4 18988627 20005715 20005715 21071413 9827804 9827804 9827804 N/A N/A SignaLink
GADD45G PIAS4 20005715 20005715 N/A N/A SignaLink
GADD45G PPARD 10872826 18988627 20005715 20005715 N/A N/A SignaLink
GADD45G PPARG 10872826 18988627 20005715 20005715 N/A N/A SignaLink
GADD45G RARA 20005715 20005715 N/A N/A SignaLink
GADD45G RXRA 10872826 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 GADD45G 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 GADD45G 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 GADD45G 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GADD45G 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 GADD45G 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 GADD45G 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 GADD45G 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GADD45G 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB GADD45G 11012671 trascriptional regulation,stimulation inferred by curator TFlink
CEBPD GADD45G 11012671 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 GADD45G 23681230 trascriptional regulation,stimulation inferred by curator TFlink
RELA GADD45G 23681230 trascriptional regulation,stimulation inferred by curator TFlink
AR GADD45G N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA GADD45G N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARD GADD45G N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG GADD45G N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA GADD45G N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PDE4DIP GADD45G 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF3G GADD45G 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPIL1 GADD45G 25348397 N/A physical interaction ComPPI
TSNAX GADD45G 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SH3GLB1 GADD45G 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RWDD2B GADD45G 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
GADD45G PPARA 25348397 N/A physical interaction,in vitro ComPPI
GADD45G PCNA 10455148 11022036 14525934 25348397 N/A affinity chromatography technology,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GADD45G PPARD 10872826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GADD45G HAP1 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
GADD45G RAN 14525934 15383276 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
GADD45G PPARG 10872826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GADD45G GDF9 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G MAP3K4 12052864 14525934 24234451 25348397 9827804 physical association two hybrid,experimental interaction detection,dihydrofolate reductase reconstruction,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
GADD45G GADD45B 11498536 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GADD45G GADD45GIP1 12716909 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
GADD45G UTP14A 14525934 15383276 21900206 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G LUC7L 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G EEF1G 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G RBM48 14525934 15383276 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
GADD45G MED31 14525934 15383276 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
GADD45G LUC7L2 14525934 15383276 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G LRIF1 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G CDKN1A 10455148 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GADD45G KAT5 14525934 15383276 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
GADD45G CCNB1 12124778 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GADD45G EEF1A1 14525934 15383276 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G ESR1 10872826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GADD45G PTN 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G GADD45A 25348397 N/A physical interaction ComPPI
GADD45G RARA 10872826 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GADD45G RXRA 10872826 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
GADD45G CDK1 10973963 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD
GADD45G IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
GADD45G MIDN 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G ZNF579 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G CRIP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G EEF1A1P5 25348397 N/A physical interaction ComPPI
GADD45G SMARCB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G EZH2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G PDIA4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G DDAH2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G SERPINA4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G RDH13 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G TRMT2A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G PHAX 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G PLEKHM1 15383276 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G PTPRK 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45G APP 25348397 N/A physical interaction ComPPI
GADD45G ARPC5L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G SH3GLB2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G SGK1 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
GADD45G HP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45G REL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GADD45G AFAP1L1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GADD45G CEP57L1 25348397 N/A physical interaction ComPPI
GADD45G CDAN1 25348397 N/A affinity chromatography technology,two hybrid,coimmunoprecipitation,physical interaction ComPPI
GADD45G MAP2K6 12052864 24234451 25348397 physical association dihydrofolate reductase reconstruction ComPPI,IntAct
GADD45G CEP126 15383276 24234451 25348397 physical association two hybrid,pull down ComPPI,IntAct
GADD45G ENKD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G RCN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G BLOC1S2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G GRAMD4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G FAM156A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G ZNF664 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G RASSF10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G DCTN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G ACTN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45G POU5F1 20505756 24234451 physical association electrophoretic mobility supershift assay IntAct
IKBKG GADD45G 20098747 27898060 N/A N/A OmniPath
MAP3K4 GADD45G 27898060 9827804 N/A N/A OmniPath

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