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GENE：GRB14

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GRB14
FullNmae growth factor receptor bound protein 14
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4565
EnsembleID ENSG00000115290
Uniprot Q14449

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GRB14 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GRB14 GO:0005515,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0007165,GO:0008286,GO:0010008,GO:0030674,GO:0030971,GO:0043231,GO:0046627,GO:0046627,GO:0060090

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FGFR1 GRB14 10713090 23331499 stimulation N/A SignaLink
TEK GRB14 20973951 23331499 stimulation N/A SignaLink
EGFR GRB14 23331499 8647858 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB14 DAPK3 20005715 interaction type N/A PSP
GRB14 INSR 20005715 interaction type N/A PSP
GRB14 PDGFRB 20005715 interaction type N/A PSP
GRB14 FGFR1 20005715 interaction type N/A PSP,SignaLink
GRB14 PDGFRA 20005715 interaction type N/A PSP
GRB14 TEK 20005715 interaction type N/A PSP
GRB14 PRKCZ 20005715 interaction type N/A PSP
GRB14 PRKCZ 12242277 18988627 20005715 N/A N/A SignaLink
GRB14 DAPK3 12242277 20005715 20005715 21071413 N/A N/A SignaLink
GRB14 INSR 11726652 16582879 18988627 20005715 20005715 21071413 N/A N/A SignaLink
GRB14 PDGFRA 18988627 20005715 20005715 8647858 N/A N/A SignaLink
GRB14 PDGFRB 18988627 20005715 20005715 8647858 N/A N/A SignaLink
GRB14 TEK 10521483 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR GRB14 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 GRB14 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 GRB14 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 GRB14 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 GRB14 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 GRB14 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GRB14 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 GRB14 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
GRB14 EGFR 25361965 interaction type N/A PTMCode2
EGFR GRB14 25361965 interaction type N/A PTMCode2
GRB14 INSR 25361965 interaction type N/A PTMCode2
INSR GRB14 25361965 interaction type N/A PTMCode2
GRB14 IRS1 25361965 interaction type N/A PTMCode2
IRS1 GRB14 25361965 interaction type N/A PTMCode2
GRB14 TNKS2 25361965 interaction type N/A PTMCode2
TNKS2 GRB14 25361965 interaction type N/A PTMCode2
GRB14 PRKCZ 25361965 interaction type N/A PTMCode2
PRKCZ GRB14 25361965 interaction type N/A PTMCode2
GRB14 FGFR1 25361965 interaction type N/A PTMCode2
FGFR1 GRB14 25361965 interaction type N/A PTMCode2
GRB14 TEK 25361965 interaction type N/A PTMCode2
TEK GRB14 25361965 interaction type N/A PTMCode2
CSF1R GRB14 25361965 interaction type N/A PTMCode2
GRB14 CSF1R 25361965 interaction type N/A PTMCode2
GRB14 HRAS 25361965 interaction type N/A PTMCode2
HRAS GRB14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 GRB14 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC5L GRB14 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FRS3 GRB14 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GSK3B GRB14 24234451 24535599 25348397 27898060 physical association proximity ligation assay ComPPI,IntAct,OmniPath
PDGFRB GRB14 14525934 25348397 8647858 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PDGFRA GRB14 14525934 25348397 8647858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRB14 PRKCZ 12242277 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB14 SQSTM1 12242277 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRB14 TNKS2 11278563 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
GRB14 IRS1 14525934 25348397 27898060 9748281 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
GRB14 INSR 14525934 16582879 24234451 25348397 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GRB14 EGFR 14525934 25348397 8647858 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB14 FGFR1 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
GRB14 DAPK3 25348397 N/A physical interaction ComPPI
GRB14 FTCD 25348397 N/A physical interaction ComPPI
GRB14 CHFR 25348397 25578860 27898060 N/A physical interaction ComPPI,OmniPath
GRB14 STK26 25348397 N/A physical interaction ComPPI
GRB14 HCK 25348397 N/A physical interaction ComPPI
GRB14 NRAS 19648926 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRB14 NFKB1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
GRB14 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GRB14 CSNK2A1 24234451 24535599 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
GRB14 TRIM27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP3K14 GRB14 12853971 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IGF1R GRB14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GRB14 TEK 10521483 14525934 N/A experimental interaction detection,two hybrid HPRD

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